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Sthe_3070 Sthe_3070 Sthe_3087 Sthe_3087 Sthe_0034 Sthe_0034 lysJ lysJ Sthe_3286 Sthe_3286 Sthe_0306 Sthe_0306 Sthe_0315 Sthe_0315 Sthe_0396 Sthe_0396 hisC hisC Sthe_0654 Sthe_0654 Sthe_0677 Sthe_0677 lysA lysA Sthe_0784 Sthe_0784 Sthe_0843 Sthe_0843 Sthe_0848 Sthe_0848 Sthe_1185 Sthe_1185 glyA glyA Sthe_1459 Sthe_1459 Sthe_1543 Sthe_1543 Sthe_1639 Sthe_1639 Sthe_1665 Sthe_1665 Sthe_3384 Sthe_3384 hemL hemL Sthe_1810 Sthe_1810 Sthe_2023 Sthe_2023 Sthe_2122 Sthe_2122 Sthe_3398 Sthe_3398 Sthe_2131 Sthe_2131 Sthe_2225 Sthe_2225 Sthe_2336 Sthe_2336 Sthe_2364 Sthe_2364 Sthe_2449 Sthe_2449 Sthe_2542 Sthe_2542 Sthe_2604 Sthe_2604 Sthe_2643 Sthe_2643 Sthe_2663 Sthe_2663 Sthe_2686 Sthe_2686 Sthe_2786 Sthe_2786 Sthe_2873 Sthe_2873 trpB-2 trpB-2
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
Sthe_3070PFAM: aminotransferase class I and II; KEGG: ank:AnaeK_1558 aminotransferase class I and II. (404 aa)
Sthe_3087Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (408 aa)
Sthe_0034Cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate- dependent protein; aromatic amino acid beta-eliminating lyase/threonine aldolase; DegT/DnrJ/EryC1/StrS aminotransferase; KEGG: sus:Acid_3250 cystathionine gamma-synthase. (409 aa)
lysJAcetylornithine and succinylornithine aminotransferase; Catalyzes the transfer of the amino group of L-glutamate to [LysW]-aminoadipate 6-semialdehyde, generating [LysW]-gamma-L-lysine. Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily. (390 aa)
Sthe_3286Putative transcriptional regulator, GntR family; PFAM: aminotransferase class I and II; KEGG: reh:H16_A2662 transcriptional regulator, MocR family. (405 aa)
Sthe_0306PFAM: aminotransferase class-III; KEGG: rca:Rcas_1811 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (457 aa)
Sthe_0315PFAM: aminotransferase class I and II; KEGG: lch:Lcho_3539 GntR family transcriptional regulator. (402 aa)
Sthe_0396PFAM: aminotransferase class V; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: rrs:RoseRS_0168 aminotransferase, class V. (392 aa)
hisCTIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; Allinase- like; aminotransferase class V; KEGG: hau:Haur_4535 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (367 aa)
Sthe_0654PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: hma:rrnAC1231 threonine dehydratase. (330 aa)
Sthe_0677PFAM: aminotransferase class-III; KEGG: cau:Caur_2616 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (463 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (441 aa)
Sthe_0784TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: sus:Acid_0546 threonine synthase. (415 aa)
Sthe_0843PFAM: aminotransferase class I and II; KEGG: mbu:Mbur_0428 aspartate aminotransferase. (389 aa)
Sthe_0848PFAM: aminotransferase class-III; KEGG: rpd:RPD_2366 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (446 aa)
Sthe_1185Alanine racemase domain protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. (239 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (422 aa)
Sthe_1459Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (420 aa)
Sthe_1543KEGG: mta:Moth_1309 O-acetylhomoserine/O- acetylserine sulfhydrylase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate- dependent protein; aromatic amino acid beta-eliminating lyase/threonine aldolase. (431 aa)
Sthe_1639Acetylornithine transaminase; PFAM: aminotransferase class-III; KEGG: rca:Rcas_3219 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (426 aa)
Sthe_1665PFAM: aminotransferase class-III; KEGG: sma:SAV_4551 hypothetical protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (452 aa)
Sthe_3384PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: afw:Anae109_3556 threonine dehydratase. (322 aa)
hemLTIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: mta:Moth_1244 glutamate-1-semialdehyde 2,1- aminomutase. (427 aa)
Sthe_1810PFAM: aminotransferase class-III; KEGG: rxy:Rxyl_1975 glutamate-1-semialdehyde 2,1- aminomutase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (457 aa)
Sthe_2023Cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate- dependent protein; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: hau:Haur_0506 cystathionine gamma-synthase. (395 aa)
Sthe_2122Threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: sen:SACE_1007 threonine synthase-like protein. (418 aa)
Sthe_3398PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: bja:bll7236 putative threonine synthase. (395 aa)
Sthe_2131PFAM: aminotransferase class I and II; aromatic amino acid beta-eliminating lyase/threonine aldolase; Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: rca:Rcas_1209 aminotransferase class I and II. (392 aa)
Sthe_2225Transcriptional regulator, GntR family with aminotransferase domain protein; PFAM: aminotransferase class I and II; regulatory protein GntR HTH; SMART: regulatory protein GntR HTH; KEGG: sth:STH2754 class I aminotransferase protein. (504 aa)
Sthe_2336PFAM: MOSC domain containing protein; KEGG: pap:PSPA7_5597 hypothetical protein. (180 aa)
Sthe_2364PFAM: Pyridoxal-dependent decarboxylase; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: gka:GK1715 diaminobutyrate-2-oxoglutarate transaminase. (483 aa)
Sthe_2449PFAM: aminotransferase class-III; KEGG: cau:Caur_2206 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (456 aa)
Sthe_2542TIGRFAM: diaminopimelate decarboxylase; PFAM: Orn/DAP/Arg decarboxylase 2; KEGG: aeh:Mlg_0126 Orn/DAP/Arg decarboxylase 2. (445 aa)
Sthe_2604PFAM: aminotransferase class I and II; Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: fph:Fphi_0426 aspartate aminotransferase. (404 aa)
Sthe_2643Cysteine desulfurase; PFAM: aminotransferase class V; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: geo:Geob_2507 aminotransferase class V. (384 aa)
Sthe_2663PFAM: aminotransferase class-III; KEGG: glutamate-1-semialdehyde 2,1-aminomutase; K01845 glutamate-1-semialdehyde 2,1-aminomutase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (429 aa)
Sthe_2686TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: pen:PSEEN3862 threonine synthase. (404 aa)
Sthe_2786TIGRFAM: L-lysine 6-transaminase; PFAM: aminotransferase class-III; KEGG: pca:Pcar_2442 L-lysine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (441 aa)
Sthe_2873PFAM: aminotransferase class-III; KEGG: smd:Smed_5339 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (451 aa)
trpB-2Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (456 aa)
Your Current Organism:
Sphaerobacter thermophilus
NCBI taxonomy Id: 479434
Other names: S. thermophilus DSM 20745, Sphaerobacter thermophilus DSM 20745, Sphaerobacter thermophilus str. DSM 20745, Sphaerobacter thermophilus strain DSM 20745
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