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rpmD rpmD Sthe_3146 Sthe_3146 Sthe_3105 Sthe_3105 Sthe_2835 Sthe_2835 Sthe_2834 Sthe_2834 Sthe_2552 Sthe_2552 Sthe_2450 Sthe_2450 Sthe_2242 Sthe_2242 Sthe_2155 Sthe_2155 rplY rplY Sthe_2007 Sthe_2007 rimM rimM rpsP rpsP glgC glgC rpmE rpmE rpmA rpmA rplU rplU rpsB rpsB gyrA gyrA Sthe_1635 Sthe_1635 rpmG rpmG rplK rplK rplA rplA rplJ rplJ rplL rplL Sthe_1598 Sthe_1598 Sthe_1597 Sthe_1597 Sthe_1596 Sthe_1596 rplI rplI rpsO rpsO hpf hpf rpsF rpsF rpsR rpsR rpsT rpsT rpmI rpmI rplT rplT Sthe_1168 Sthe_1168 gyrB gyrB rpsI rpsI rplM rplM rplQ rplQ rpsD-2 rpsD-2 rpsK rpsK rpsM rpsM rpmJ rpmJ rplO rplO rpsE rpsE rplR rplR rplF rplF rpsH rpsH rpsZ rpsZ rplE rplE rplX rplX rplN rplN rpsQ rpsQ rpmC rpmC rplP rplP rpsC rpsC rplV rplV rpsS rpsS rplB rplB rplW rplW rplD rplD rplC rplC rpsJ rpsJ rpsG rpsG rpsL rpsL recO recO recR recR Sthe_0921 Sthe_0921 Sthe_0882 Sthe_0882 Sthe_0881 Sthe_0881 gvpA gvpA rpsU rpsU Sthe_0600 Sthe_0600 Sthe_0516 Sthe_0516 Sthe_0509 Sthe_0509 Sthe_0495 Sthe_0495 rplS rplS Sthe_0425 Sthe_0425 dnaG dnaG rpmF rpmF rpsD rpsD priA priA rpmH rpmH Sthe_0083 Sthe_0083 Sthe_0081 Sthe_0081
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rpmDTIGRFAM: ribosomal protein L30; PFAM: ribosomal protein L30; KEGG: cau:Caur_2387 ribosomal protein L30. (64 aa)
Sthe_3146Hypothetical protein. (198 aa)
Sthe_3105KEGG: hypothetical protein. (665 aa)
Sthe_2835KEGG: pca:Pcar_0796 hypothetical protein. (672 aa)
Sthe_2834PFAM: zinc finger CHC2-family protein; SMART: zinc finger CHC2-family protein; KEGG: hha:Hhal_1100 DNA primase. (214 aa)
Sthe_2552PFAM: protein of unknown function DUF362; KEGG: gur:Gura_0351 hypothetical protein. (366 aa)
Sthe_2450PFAM: protein of unknown function DUF74; KEGG: gvi:gll1048 hypothetical protein; Belongs to the UPF0145 family. (107 aa)
Sthe_2242PFAM: zinc finger CHC2-family protein; SMART: zinc finger CHC2-family protein; KEGG: rba:RB6344 DNA primase. (198 aa)
Sthe_2155Conserved hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. (102 aa)
rplYRibosomal 5S rRNA E-loop binding protein Ctc/L25/TL5; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily. (218 aa)
Sthe_2007TIGRFAM: squalene-hopene cyclase; squalene/oxidosqualene cyclase; PFAM: Prenyltransferase/squalene oxidase; KEGG: ace:Acel_1697 squalene-hopene cyclase. (617 aa)
rimM16S rRNA processing protein RimM; An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes; Belongs to the RimM family. (178 aa)
rpsPTIGRFAM: ribosomal protein S16; PFAM: ribosomal protein S16; KEGG: lme:LEUM_1485 SSU ribosomal protein S16P; Belongs to the bacterial ribosomal protein bS16 family. (107 aa)
glgCGlucose-1-phosphate adenylyltransferase; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. (427 aa)
rpmERibosomal protein L31; Binds the 23S rRNA. (110 aa)
rpmATIGRFAM: ribosomal protein L27; PFAM: ribosomal protein L27; KEGG: gme:Gmet_3196 50S ribosomal protein L27; Belongs to the bacterial ribosomal protein bL27 family. (97 aa)
rplURibosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (103 aa)
rpsBTIGRFAM: ribosomal protein S2; PFAM: ribosomal protein S2; KEGG: afl:Aflv_1709 ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. (269 aa)
gyrADNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (836 aa)
Sthe_1635PFAM: ADP-ribosylation/Crystallin J1; KEGG: afu:AF1724 dinitrogenase reductase activating glycohydrolase (DraG). (339 aa)
rpmGTIGRFAM: ribosomal protein L33; PFAM: ribosomal protein L33; KEGG: dth:DICTH_1264 ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family. (56 aa)
rplKRibosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (141 aa)
rplARibosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (241 aa)
rplJRibosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (178 aa)
rplLRibosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (132 aa)
Sthe_1598PFAM: IstB domain protein ATP-binding protein; Chromosomal replication initiator DnaA; SMART: AAA ATPase; KEGG: rrs:RoseRS_1147 IstB ATP binding domain- containing protein. (241 aa)
Sthe_1597TIGRFAM: primosome, DnaD subunit; PFAM: DnaD and phage-associated region; KEGG: rca:Rcas_3989 primosome, DnaD subunit. (244 aa)
Sthe_1596Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (447 aa)
rplIRibosomal protein L9; Binds to the 23S rRNA. (183 aa)
rpsORibosomal protein S15; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. (89 aa)
hpfSigma 54 modulation protein/ribosomal protein S30EA; Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth. (194 aa)
rpsFRibosomal protein S6; Binds together with S18 to 16S ribosomal RNA. (109 aa)
rpsRRibosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (128 aa)
rpsTRibosomal protein S20; Binds directly to 16S ribosomal RNA. (91 aa)
rpmITIGRFAM: ribosomal protein L35; PFAM: ribosomal protein L35; KEGG: deb:DehaBAV1_0679 50S ribosomal protein L35; Belongs to the bacterial ribosomal protein bL35 family. (66 aa)
rplTRibosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (117 aa)
Sthe_1168Histone family protein DNA-binding protein; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (97 aa)
gyrBDNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (638 aa)
rpsIPFAM: ribosomal protein S9; KEGG: cau:Caur_2400 ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family. (147 aa)
rplMRibosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (144 aa)
rplQTIGRFAM: ribosomal protein L17; PFAM: ribosomal protein L17; KEGG: mrd:Mrad2831_2190 ribosomal protein L17. (117 aa)
rpsD-2Ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (214 aa)
rpsKRibosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (136 aa)
rpsMRibosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (124 aa)
rpmJTIGRFAM: ribosomal protein L36; PFAM: ribosomal protein L36; KEGG: lch:Lcho_3927 ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family. (37 aa)
rplORibosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (146 aa)
rpsERibosomal protein S5; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family. (180 aa)
rplRRibosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (125 aa)
rplFRibosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (181 aa)
rpsHRibosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (132 aa)
rpsZRibosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. (61 aa)
rplERibosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (181 aa)
rplXRibosomal protein L24; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. (108 aa)
rplNRibosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa)
rpsQRibosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (95 aa)
rpmCTIGRFAM: ribosomal protein L29; PFAM: ribosomal protein L29; KEGG: xau:Xaut_1687 ribosomal protein L29; Belongs to the universal ribosomal protein uL29 family. (73 aa)
rplPRibosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (150 aa)
rpsCRibosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (224 aa)
rplVRibosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (114 aa)
rpsSRibosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (94 aa)
rplBRibosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (276 aa)
rplWRibosomal protein L25/L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (99 aa)
rplDRibosomal protein L4/L1e; Forms part of the polypeptide exit tunnel. (209 aa)
rplCRibosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (216 aa)
rpsJRibosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (106 aa)
rpsGRibosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa)
rpsLRibosomal protein S12; Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit. (141 aa)
recODNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. (276 aa)
recRRecombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (201 aa)
Sthe_0921KEGG: rrs:RoseRS_3193 hypothetical protein. (375 aa)
Sthe_0882Gas vesicle protein GVPa; Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth. (139 aa)
Sthe_0881PFAM: Gas vesicle K; KEGG: pth:PTH_0425 hypothetical protein. (155 aa)
gvpAGas vesicle protein GVPa; Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth. GvpA type proteins form the essential core of the structure. (171 aa)
rpsUTIGRFAM: ribosomal protein S21; KEGG: cau:Caur_0492 ribosomal protein S21; Belongs to the bacterial ribosomal protein bS21 family. (70 aa)
Sthe_0600PFAM: ADP-ribosylation/Crystallin J1; KEGG: dol:Dole_0265 ADP-ribosylation/crystallin J1. (369 aa)
Sthe_0516PFAM: DNA polymerase B region; DNA polymerase B exonuclease; SMART: DNA-directed DNA polymerase B; KEGG: gsu:GSU3245 DNA polymerase II, putative. (730 aa)
Sthe_0509Hypothetical protein. (196 aa)
Sthe_0495PFAM: RNA binding S1 domain protein; SMART: RNA binding S1 domain protein; KEGG: cau:Caur_2474 RNA-binding S1 domain- containing protein. (459 aa)
rplSRibosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (123 aa)
Sthe_0425PFAM: AAA ATPase central domain protein; ATPase associated with various cellular activities AAA_5; magnesium chelatase ChlI subunit; SMART: AAA ATPase; KEGG: rrs:RoseRS_3807 recombination factor protein RarA. (460 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (615 aa)
rpmFTIGRFAM: ribosomal protein L32; PFAM: ribosomal L32p protein; KEGG: rca:Rcas_1804 ribosomal protein L32; Belongs to the bacterial ribosomal protein bL32 family. (68 aa)
rpsDRibosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (203 aa)
priAPrimosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (824 aa)
rpmHTIGRFAM: ribosomal protein L34; PFAM: ribosomal protein L34; KEGG: hau:Haur_0767 ribosomal protein L34; Belongs to the bacterial ribosomal protein bL34 family. (54 aa)
Sthe_0083KEGG: tte:TTE0010 DNA gyrase subunit B; PFAM: DNA topoisomerase type IIA subunit B region 2 domain protein; DNA gyrase subunit B domain protein; ATP- binding region ATPase domain protein; SMART: DNA topoisomerase II; ATP-binding region ATPase domain protein. (674 aa)
Sthe_0081DNA topoisomerase (ATP-hydrolyzing); KEGG: chy:CHY_2704 DNA gyrase, A subunit; PFAM: DNA gyrase/topoisomerase IV subunit A; DNA gyrase repeat beta-propeller; SMART: DNA gyrase/topoisomerase IV subunit A. (813 aa)
Your Current Organism:
Sphaerobacter thermophilus
NCBI taxonomy Id: 479434
Other names: S. thermophilus DSM 20745, Sphaerobacter thermophilus DSM 20745, Sphaerobacter thermophilus str. DSM 20745, Sphaerobacter thermophilus strain DSM 20745
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