STRINGSTRING
Sthe_3347 Sthe_3347 Sthe_0198 Sthe_0198 Sthe_0199 Sthe_0199 lysY lysY Sthe_0362 Sthe_0362 glyQS glyQS grpE grpE Sthe_0811 Sthe_0811 rpoA rpoA clpX clpX Sthe_1549 Sthe_1549 Sthe_1551 Sthe_1551 Sthe_1616 Sthe_1616 Sthe_1617 Sthe_1617 Sthe_3242 Sthe_3242
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Sthe_3347KEGG: bph:Bphy_7756 PAS sensor protein; PFAM: GAF domain protein; histidine kinase dimerisation and phosphoacceptor region; ATP-binding region ATPase domain protein; SMART: GAF domain protein; ATP-binding region ATPase domain protein. (555 aa)
Sthe_0198Putative signal transduction histidine kinase; PFAM: GAF domain protein; ATP-binding region ATPase domain protein; SMART: GAF domain protein; KEGG: rca:Rcas_3064 GAF sensor signal transduction histidine kinase. (780 aa)
Sthe_0199PFAM: histidine kinase dimerisation and phosphoacceptor region; GAF domain protein; ATP-binding region ATPase domain protein; SMART: ATP-binding region ATPase domain protein; GAF domain protein; KEGG: cau:Caur_0656 histidine kinase dimerisation and phosphoacceptor region. (420 aa)
lysYN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of [LysW]- aminoadipate 6-phosphate to yield [LysW]-aminoadipate 6-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily. (349 aa)
Sthe_0362Phosphate uptake regulator, PhoU; Plays a role in the regulation of phosphate uptake. (231 aa)
glyQSglycyl-tRNA synthetase; Catalyzes the attachment of glycine to tRNA(Gly). Belongs to the class-II aminoacyl-tRNA synthetase family. (469 aa)
grpEGrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] (195 aa)
Sthe_0811PFAM: histidine kinase dimerisation and phosphoacceptor region; KEGG: rca:Rcas_1122 histidine kinase. (362 aa)
rpoADNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (340 aa)
clpXSigma 54 interacting domain protein; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (419 aa)
Sthe_1549KEGG: cau:Caur_0217 aspartate-semialdehyde dehydrogenase; TIGRFAM: aspartate-semialdehyde dehydrogenase; PFAM: Semialdehyde dehydrogenase dimerisation region; Semialdehyde dehydrogenase NAD - binding; Belongs to the aspartate-semialdehyde dehydrogenase family. (351 aa)
Sthe_1551Histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase dimerisation and phosphoacceptor region; SMART: ATP-binding region ATPase domain protein; KEGG: rxy:Rxyl_0159 periplasmic sensor signal transduction histidine kinase. (437 aa)
Sthe_1616Histidine kinase; PFAM: ATP-binding region ATPase domain protein; SMART: ATP-binding region ATPase domain protein; KEGG: rrs:RoseRS_0939 histidine kinase. (218 aa)
Sthe_1617KEGG: hypothetical protein. (139 aa)
Sthe_3242KEGG: afw:Anae109_4151 multi-sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase dimerisation and phosphoacceptor region; GAF domain protein; SMART: ATP-binding region ATPase domain protein; GAF domain protein. (883 aa)
Your Current Organism:
Sphaerobacter thermophilus
NCBI taxonomy Id: 479434
Other names: S. thermophilus DSM 20745, Sphaerobacter thermophilus DSM 20745, Sphaerobacter thermophilus str. DSM 20745, Sphaerobacter thermophilus strain DSM 20745
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