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truA truA Sthe_1071 Sthe_1071 lysS lysS Sthe_3246 Sthe_3246 Sthe_3255 Sthe_3255 miaA miaA Sthe_3293 Sthe_3293 Sthe_3325 Sthe_3325 Sthe_3473 Sthe_3473 Sthe_3489 Sthe_3489 cysS-2 cysS-2 rlmN rlmN Sthe_1124 Sthe_1124 Sthe_1150 Sthe_1150 Sthe_1155 Sthe_1155 fmt fmt tgt tgt pth pth aspS aspS Sthe_1222 Sthe_1222 truB truB tyrS tyrS queA queA proS proS rnz rnz Sthe_1356 Sthe_1356 leuS leuS Sthe_1466 Sthe_1466 Sthe_1550 Sthe_1550 alaS alaS cysS cysS valS valS serS serS gatB gatB pheS pheS pheT pheT Sthe_1674 Sthe_1674 Sthe_1769 Sthe_1769 hemA hemA Sthe_2317 Sthe_2317 Sthe_2329 Sthe_2329 Sthe_2520 Sthe_2520 Sthe_2638 Sthe_2638 Sthe_2646 Sthe_2646 metG metG thiI thiI trpS trpS Sthe_3237 Sthe_3237 Sthe_1822 Sthe_1822 Sthe_1831 Sthe_1831 Sthe_1909 Sthe_1909 gatA gatA gatC gatC Sthe_2016 Sthe_2016 Sthe_2018 Sthe_2018 gltX gltX argS argS Sthe_0123 Sthe_0123 rnpA rnpA Sthe_0257 Sthe_0257 Sthe_0316 Sthe_0316 Sthe_0337 Sthe_0337 rph rph thrS thrS glyQS glyQS hisS hisS selA selA dtd dtd Sthe_0850 Sthe_0850 Sthe_0875 Sthe_0875 Sthe_0879 Sthe_0879 Sthe_0907 Sthe_0907 Sthe_0938 Sthe_0938 trmD trmD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
truAtRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (271 aa)
Sthe_1071PFAM: beta-lactamase domain protein; KEGG: fre:Franean1_3962 beta-lactamase domain- containing protein. (267 aa)
lysSTIGRFAM: lysyl-tRNA synthetase; PFAM: tRNA synthetase class II (D K and N); nucleic acid binding OB-fold tRNA/helicase-type; KEGG: cau:Caur_1226 lysyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (513 aa)
Sthe_3246Integral membrane protein-like protein; KEGG: bxe:Bxe_A3828 hypothetical protein. (380 aa)
Sthe_3255PFAM: Amidase; KEGG: bbr:BB4983 amidase; Belongs to the amidase family. (474 aa)
miaAtRNA delta(2)-isopentenylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (330 aa)
Sthe_3293PFAM: Amidase; KEGG: mxa:MXAN_3566 amidase. (542 aa)
Sthe_3325KEGG: hypothetical protein. (259 aa)
Sthe_3473KEGG: psb:Psyr_0099 hypothetical protein. (73 aa)
Sthe_3489PFAM: Amidase; KEGG: reu:Reut_B5142 amidase. (506 aa)
cysS-2KEGG: aeh:Mlg_1810 cysteinyl-tRNA synthetase; TIGRFAM: cysteinyl-tRNA synthetase; PFAM: Cysteinyl-tRNA synthetase class Ia; tRNA synthetase class I (M); Belongs to the class-I aminoacyl-tRNA synthetase family. (399 aa)
rlmNRadical SAM enzyme, Cfr family; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family. (347 aa)
Sthe_1124PFAM: formyl transferase domain protein; KEGG: cau:Caur_2005 formyl transferase domain- containing protein. (230 aa)
Sthe_1150PFAM: formyl transferase domain protein; KEGG: plu:plu1413 hypothetical protein. (230 aa)
Sthe_1155PFAM: conserved hypothetical protein; KEGG: rca:Rcas_4270 hypothetical protein. (365 aa)
fmtmethionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (314 aa)
tgtQueuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] (414 aa)
pthpeptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family. (214 aa)
aspSaspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (609 aa)
Sthe_1222PFAM: Amidase; KEGG: afu:AF1954 Glu-tRNA amidotransferase, subunit A (GatA-1); Belongs to the amidase family. (514 aa)
truBtRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. (299 aa)
tyrStyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily. (407 aa)
queAS-adenosylmethionine/tRNA-ribosyltransferase- isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (341 aa)
proSprolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). (483 aa)
rnzRibonuclease Z; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family. (304 aa)
Sthe_1356PFAM: protein of unknown function DUF402; KEGG: rrs:RoseRS_0508 hypothetical protein. (175 aa)
leuSTIGRFAM: leucyl-tRNA synthetase; KEGG: rxy:Rxyl_3202 leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (824 aa)
Sthe_1466PFAM: B3/4 domain protein; KEGG: asu:Asuc_1302 B3/4 domain-containing protein. (236 aa)
Sthe_1550PFAM: conserved hypothetical protein; KEGG: cau:Caur_3608 hypothetical protein. (351 aa)
alaSalanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (879 aa)
cysSKEGG: rrs:RoseRS_3036 cysteinyl-tRNA synthetase; TIGRFAM: cysteinyl-tRNA synthetase; PFAM: Cysteinyl-tRNA synthetase class Ia; Cysteinyl-tRNA synthetase class Ia DALR; tRNA synthetase class I (M); Belongs to the class-I aminoacyl-tRNA synthetase family. (468 aa)
valSvalyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (894 aa)
serSseryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (427 aa)
gatBglutamyl-tRNA(Gln) amidotransferase, B subunit; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (482 aa)
pheSTIGRFAM: phenylalanyl-tRNA synthetase, alpha subunit; PFAM: phenylalanyl-tRNA synthetase class IIc; aminoacyl tRNA synthetase class II domain protein; KEGG: rca:Rcas_1438 phenylalanyl-tRNA synthetase, alpha subunit; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (347 aa)
pheTKEGG: hau:Haur_4633 phenylalanyl-tRNA synthetase, beta subunit; TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (818 aa)
Sthe_1674Histidine--tRNA ligase; PFAM: tRNA synthetase class II (G H P and S); Anticodon-binding domain protein; KEGG: rca:Rcas_2915 histidyl-tRNA synthetase. (495 aa)
Sthe_1769Hypothetical protein; KEGG: rxy:Rxyl_1965 conserved hypothetical protein 374. (361 aa)
hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (422 aa)
Sthe_2317PFAM: Amidase; KEGG: sus:Acid_7160 amidase. (467 aa)
Sthe_2329KEGG: dsy:DSY1442 hypothetical protein. (565 aa)
Sthe_2520PFAM: Amidase; KEGG: bpt:Bpet1417 glutamyl-tRNA(Gln) amidotransferase subunit A; Belongs to the amidase family. (472 aa)
Sthe_2638PFAM: YbaK/prolyl-tRNA synthetase associated region; KEGG: gbm:Gbem_1948 YbaK/prolyl-tRNA synthetase associated region. (160 aa)
Sthe_2646TIGRFAM: methionyl-tRNA synthetase; PFAM: tRNA synthetase class I (M); KEGG: afw:Anae109_3095 tRNA synthetase class I (M). (525 aa)
metGmethionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (593 aa)
thiIThiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (404 aa)
trpStryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (348 aa)
Sthe_3237PFAM: Amidase; KEGG: aeh:Mlg_2453 amidase. (539 aa)
Sthe_1822PFAM: Amidase; KEGG: cau:Caur_1377 amidase. (547 aa)
Sthe_1831PFAM: Amidase; KEGG: sma:SAV_7269 amidase. (466 aa)
Sthe_1909KEGG: fre:Franean1_0115 hypothetical protein. (258 aa)
gatAglutamyl-tRNA(Gln) amidotransferase, A subunit; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (497 aa)
gatCglutamyl-tRNA(Gln) amidotransferase, C subunit; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (97 aa)
Sthe_2016TIGRFAM: export-related chaperone CsaA; PFAM: t-RNA-binding domain protein; KEGG: rxy:Rxyl_3199 secretion chaperone CsaA. (109 aa)
Sthe_2018PFAM: conserved hypothetical protein; KEGG: cau:Caur_0535 hypothetical protein. (329 aa)
gltXglutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (497 aa)
argSarginyl-tRNA synthetase; KEGG: bba:Bd2027 hypothetical protein; TIGRFAM: arginyl-tRNA synthetase. (724 aa)
Sthe_0123KEGG: ace:Acel_2052 cysteinyl-tRNA synthetase-like. (267 aa)
rnpARibonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. (129 aa)
Sthe_0257PFAM: YbaK/prolyl-tRNA synthetase associated region; KEGG: sgr:SGR_4336 hypothetical protein. (179 aa)
Sthe_0316PFAM: Threonyl/alanyl tRNA synthetase SAD; KEGG: rxy:Rxyl_2571 Ala-tRNA(Pro) hydrolase. (247 aa)
Sthe_0337TIGRFAM: isoleucyl-tRNA synthetase; KEGG: rxy:Rxyl_2428 isoleucyl-tRNA synthetase. (1060 aa)
rphRibonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (246 aa)
thrSTIGRFAM: threonyl-tRNA synthetase; PFAM: tRNA synthetase class II (G H P and S); Anticodon-binding domain protein; Threonyl/alanyl tRNA synthetase SAD; KEGG: deb:DehaBAV1_0681 Ser-tRNA(Thr) hydrolase / threonyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (596 aa)
glyQSglycyl-tRNA synthetase; Catalyzes the attachment of glycine to tRNA(Gly). Belongs to the class-II aminoacyl-tRNA synthetase family. (469 aa)
hisSKEGG: rca:Rcas_0121 histidyl-tRNA synthetase; TIGRFAM: histidyl-tRNA synthetase; PFAM: tRNA synthetase class II (G H P and S); Anticodon-binding domain protein. (455 aa)
selAL-seryl-tRNA selenium transferase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. (478 aa)
dtdD-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (149 aa)
Sthe_0850KEGG: dsh:Dshi_4166 hypothetical protein. (321 aa)
Sthe_0875PFAM: Gas vesicle synthesis GvpLGvpF; KEGG: gur:Gura_2834 gas vesicle synthesis GvpLGvpF. (257 aa)
Sthe_0879PFAM: Gas vesicle synthesis GvpLGvpF; KEGG: pth:PTH_0426 hypothetical protein. (252 aa)
Sthe_0907PFAM: Amidase; KEGG: bra:BRADO4401 putative amidase; Belongs to the amidase family. (469 aa)
Sthe_0938PFAM: B3/4 domain protein; KEGG: pac:PPA2209 hypothetical protein. (244 aa)
trmDtRNA (guanine-N1)-methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. (243 aa)
Your Current Organism:
Sphaerobacter thermophilus
NCBI taxonomy Id: 479434
Other names: S. thermophilus DSM 20745, Sphaerobacter thermophilus DSM 20745, Sphaerobacter thermophilus str. DSM 20745, Sphaerobacter thermophilus strain DSM 20745
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