STRINGSTRING
argG argG Sthe_3453 Sthe_3453 hldE hldE Sthe_0063 Sthe_0063 Sthe_0206 Sthe_0206 queC queC Sthe_0337 Sthe_0337 panC panC tilS tilS Sthe_0824 Sthe_0824 Sthe_0825 Sthe_0825 Sthe_1261 Sthe_1261 nadE nadE tyrS tyrS guaA guaA Sthe_1433 Sthe_1433 leuS leuS cysS cysS cysS-2 cysS-2 valS valS Sthe_1643 Sthe_1643 nadD nadD Sthe_1751 Sthe_1751 coaD coaD gltX gltX Sthe_2289 Sthe_2289 argS argS mnmA mnmA Sthe_2505 Sthe_2505 Sthe_2646 Sthe_2646 metG metG Sthe_2667 Sthe_2667 thiI thiI Sthe_2903 Sthe_2903 Sthe_2904 Sthe_2904 Sthe_3064 Sthe_3064 trpS trpS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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argGArgininosuccinate synthase; KEGG: Os12g0235800; hypothetical protein; K01940 argininosuccinate synthase; TIGRFAM: argininosuccinate synthase; PFAM: argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (409 aa)
Sthe_3453PFAM: CBS domain containing protein; UspA domain protein; SMART: CBS domain containing protein; KEGG: tgr:Tgr7_3238 universal stress protein. (465 aa)
hldECytidyltransferase-related domain protein; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (507 aa)
Sthe_0063PFAM: UspA domain protein; SMART: CBS domain containing protein; KEGG: rrs:RoseRS_0914 UspA domain-containing protein. (379 aa)
Sthe_0206KEGG: mka:MK0942 argininosuccinate synthase; TIGRFAM: argininosuccinate synthase; PFAM: argininosuccinate synthase; ExsB family protein; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (396 aa)
queCexsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (230 aa)
Sthe_0337TIGRFAM: isoleucyl-tRNA synthetase; KEGG: rxy:Rxyl_2428 isoleucyl-tRNA synthetase. (1060 aa)
panCPantoate/beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (280 aa)
tilStRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (468 aa)
Sthe_0824PFAM: Electron transfer flavoprotein alpha/beta- subunit; KEGG: cbb:CLD_2385 electron transfer flavoprotein, beta subunit/FixA family protein. (255 aa)
Sthe_0825PFAM: Electron transfer flavoprotein alpha subunit; Electron transfer flavoprotein alpha/beta-subunit; KEGG: pth:PTH_1553 electron transfer flavoprotein, alpha subunit. (332 aa)
Sthe_1261TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: FAD synthetase; cytidylyltransferase; Riboflavin kinase; KEGG: rsa:RSal33209_0668 FMN adenylyltransferase; Belongs to the ribF family. (331 aa)
nadENAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. (247 aa)
tyrStyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily. (407 aa)
guaAGMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (531 aa)
Sthe_1433PFAM: protein of unknown function DUF218; KEGG: rha:RHA1_ro01217 hypothetical protein. (216 aa)
leuSTIGRFAM: leucyl-tRNA synthetase; KEGG: rxy:Rxyl_3202 leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (824 aa)
cysSKEGG: rrs:RoseRS_3036 cysteinyl-tRNA synthetase; TIGRFAM: cysteinyl-tRNA synthetase; PFAM: Cysteinyl-tRNA synthetase class Ia; Cysteinyl-tRNA synthetase class Ia DALR; tRNA synthetase class I (M); Belongs to the class-I aminoacyl-tRNA synthetase family. (468 aa)
cysS-2KEGG: aeh:Mlg_1810 cysteinyl-tRNA synthetase; TIGRFAM: cysteinyl-tRNA synthetase; PFAM: Cysteinyl-tRNA synthetase class Ia; tRNA synthetase class I (M); Belongs to the class-I aminoacyl-tRNA synthetase family. (399 aa)
valSvalyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (894 aa)
Sthe_1643PFAM: UspA domain protein; KEGG: det:DET0028 universal stress protein. (146 aa)
nadDNicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (205 aa)
Sthe_1751TIGRFAM: cytidyltransferase-related domain protein; PFAM: cytidylyltransferase; KEGG: cau:Caur_2177 cytidyltransferase-like protein. (171 aa)
coaDPantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (168 aa)
gltXglutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (497 aa)
Sthe_2289PFAM: UspA domain protein; KEGG: rrs:RoseRS_0912 UspA domain-containing protein. (296 aa)
argSarginyl-tRNA synthetase; KEGG: bba:Bd2027 hypothetical protein; TIGRFAM: arginyl-tRNA synthetase. (724 aa)
mnmAtRNA(5-methylaminomethyl-2-thiouridylate)-methyl transferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. (353 aa)
Sthe_2505PFAM: UspA domain protein; KEGG: neu:NE1201 universal stress protein. (314 aa)
Sthe_2646TIGRFAM: methionyl-tRNA synthetase; PFAM: tRNA synthetase class I (M); KEGG: afw:Anae109_3095 tRNA synthetase class I (M). (525 aa)
metGmethionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (593 aa)
Sthe_2667PFAM: UspA domain protein; KEGG: net:Neut_1753 UspA domain-containing protein. (313 aa)
thiIThiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (404 aa)
Sthe_2903PFAM: Electron transfer flavoprotein alpha subunit; Electron transfer flavoprotein alpha/beta-subunit; KEGG: bba:Bd0021 electron transfer flavoprotein subunit alpha. (319 aa)
Sthe_2904PFAM: Electron transfer flavoprotein alpha/beta- subunit; KEGG: sat:SYN_02636 electron transfer flavoprotein beta-subunit. (261 aa)
Sthe_3064PFAM: UspA domain protein; KEGG: sfu:Sfum_0641 UspA domain protein. (303 aa)
trpStryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (348 aa)
Your Current Organism:
Sphaerobacter thermophilus
NCBI taxonomy Id: 479434
Other names: S. thermophilus DSM 20745, Sphaerobacter thermophilus DSM 20745, Sphaerobacter thermophilus str. DSM 20745, Sphaerobacter thermophilus strain DSM 20745
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