STRINGSTRING
Sthe_0310 Sthe_0310 Sthe_0533 Sthe_0533 pfp pfp Sthe_0770 Sthe_0770 Sthe_1002 Sthe_1002 Sthe_1228 Sthe_1228 tpiA tpiA pgk pgk Sthe_1253 Sthe_1253 pckA pckA pfkA pfkA acsA acsA gpmI gpmI eno eno Sthe_1933 Sthe_1933 Sthe_1934 Sthe_1934 pdhA pdhA Sthe_1938 Sthe_1938 Sthe_2025 Sthe_2025 Sthe_2121 Sthe_2121 Sthe_2381 Sthe_2381 tal tal Sthe_2817 Sthe_2817 Sthe_2818 Sthe_2818 Sthe_2819 Sthe_2819 Sthe_3226 Sthe_3226 Sthe_3385 Sthe_3385 Sthe_3478 Sthe_3478 Sthe_3523 Sthe_3523
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
Sthe_0310PFAM: ROK family protein; KEGG: mlo:mlr7234 glucose kinase. (325 aa)
Sthe_0533PFAM: CoA-binding domain protein; ATP-grasp domain protein; KEGG: bpy:Bphyt_4084 CoA-binding domain protein. (743 aa)
pfpPhosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (402 aa)
Sthe_0770KEGG: cau:Caur_2963 pyruvate phosphate dikinase; TIGRFAM: pyruvate, phosphate dikinase; PFAM: pyruvate phosphate dikinase PEP/pyruvate- binding; PEP-utilising protein mobile region; PEP- utilizing protein; Belongs to the PEP-utilizing enzyme family. (877 aa)
Sthe_1002TIGRFAM: fructose-1,6-bisphosphatase, class II; PFAM: GlpX family protein; KEGG: tfu:Tfu_0464 fructose 1,6-bisphosphatase II. (328 aa)
Sthe_1228PFAM: ROK family protein; KEGG: pth:PTH_2734 transcriptional regulator/sugar kinase. (335 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (254 aa)
pgkPFAM: phosphoglycerate kinase; KEGG: mta:Moth_0263 phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (394 aa)
Sthe_1253KEGG: csc:Csac_1953 glyceraldehyde-3-phosphate dehydrogenase, type I; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: glyceraldehyde 3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (338 aa)
pckAPhosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (533 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (374 aa)
acsAacetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (659 aa)
gpmIPhosphoglycerate mutase, 2,3-bisphosphoglycerate- independent; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (519 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (433 aa)
Sthe_1933PFAM: catalytic domain of components of various dehydrogenase complexes; biotin/lipoyl attachment domain- containing protein; E3 binding domain protein; KEGG: rrs:RoseRS_1726 dihydrolipoyllysine-residue succinyltransferase. (443 aa)
Sthe_1934Transketolase central region; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (331 aa)
pdhAPyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (336 aa)
Sthe_1938KEGG: acr:Acry_0178 pyruvate kinase; TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; Belongs to the pyruvate kinase family. (476 aa)
Sthe_2025PFAM: AMP-dependent synthetase and ligase; KEGG: pcl:Pcal_0155 AMP-dependent synthetase and ligase. (641 aa)
Sthe_2121Transketolase domain protein; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (801 aa)
Sthe_2381PFAM: AMP-dependent synthetase and ligase; KEGG: sth:STH1025 acetyl-coenzyme A synthetase. (657 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the GPI family. (942 aa)
Sthe_2817PFAM: PEP-utilising protein mobile region; KEGG: gme:Gmet_2100 hypothetical protein. (605 aa)
Sthe_2818PFAM: pyruvate phosphate dikinase PEP/pyruvate- binding; KEGG: gme:Gmet_2101 pyruvate phosphate dikinase, PEP/pyruvate-binding. (358 aa)
Sthe_2819PFAM: PEP-utilising protein mobile region; KEGG: bbt:BBta_1604 hypothetical protein. (606 aa)
Sthe_3226PFAM: alpha/beta hydrolase fold; biotin/lipoyl attachment domain-containing protein; KEGG: pag:PLES_07751 branched-chain alpha-keto acid dehydrogenase subunit E2. (376 aa)
Sthe_3385PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: reu:Reut_B5201 zinc-containing alcohol dehydrogenase superfamily protein. (359 aa)
Sthe_3478TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: pyridine nucleotide-disulphide oxidoreductase dimerisation region; FAD-dependent pyridine nucleotide- disulphide oxidoreductase; glucose-inhibited division protein A; KEGG: pla:Plav_3138 dihydrolipoamide dehydrogenase. (464 aa)
Sthe_3523PFAM: AMP-dependent synthetase and ligase; KEGG: dal:Dalk_0007 AMP-dependent synthetase and ligase. (552 aa)
Your Current Organism:
Sphaerobacter thermophilus
NCBI taxonomy Id: 479434
Other names: S. thermophilus DSM 20745, Sphaerobacter thermophilus DSM 20745, Sphaerobacter thermophilus str. DSM 20745, Sphaerobacter thermophilus strain DSM 20745
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