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ppa ppa nuoA nuoA nuoB nuoB nuoC nuoC nuoD nuoD nuoH nuoH Sthe_0297 Sthe_0297 nuoK nuoK Sthe_0299 Sthe_0299 Sthe_0300 Sthe_0300 nuoN nuoN Sthe_0614 Sthe_0614 Sthe_0631 Sthe_0631 Sthe_0996 Sthe_0996 Sthe_0997 Sthe_0997 Sthe_0998 Sthe_0998 Sthe_0999 Sthe_0999 Sthe_1238 Sthe_1238 Sthe_1239 Sthe_1239 atpC atpC atpD atpD atpG atpG atpA atpA atpH atpH atpF atpF atpE atpE atpB atpB Sthe_1582 Sthe_1582 Sthe_1583 Sthe_1583 Sthe_1585 Sthe_1585 nuoI nuoI Sthe_1654 Sthe_1654 Sthe_1835 Sthe_1835 Sthe_1836 Sthe_1836 Sthe_2052 Sthe_2052 Sthe_2053 Sthe_2053 Sthe_2934 Sthe_2934 Sthe_3102 Sthe_3102 Sthe_3163 Sthe_3163 ctaB ctaB Sthe_3191 Sthe_3191 Sthe_3192 Sthe_3192 Sthe_3193 Sthe_3193
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
ppaInorganic diphosphatase; Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions. (167 aa)
nuoANADH-ubiquinone/plastoquinone oxidoreductase chain 3; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 3 family. (118 aa)
nuoBNADH-quinone oxidoreductase, B subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (185 aa)
nuoCNADH (or F420H2) dehydrogenase, subunit C; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I 30 kDa subunit family. (202 aa)
nuoDNADH dehydrogenase I, D subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I 49 kDa subunit family. (410 aa)
nuoHNADH dehydrogenase (quinone); NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone. (343 aa)
Sthe_0297NADH-ubiquinone/plastoquinone oxidoreductase chain 6; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (242 aa)
nuoKNADH-ubiquinone oxidoreductase chain 4L; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 4L family. (102 aa)
Sthe_0299KEGG: glo:Glov_3127 proton-translocating NADH- quinone oxidoreductase, chain L; TIGRFAM: proton-translocating NADH-quinone oxidoreductase, chain L; PFAM: NADH/Ubiquinone/plastoquinone (complex I); NADH-Ubiquinone oxidoreductase (complex I) chain 5/L domain protein. (632 aa)
Sthe_0300KEGG: mgm:Mmc1_3623 proton-translocating NADH- quinone oxidoreductase, chain M; TIGRFAM: proton-translocating NADH-quinone oxidoreductase, chain M; PFAM: NADH/Ubiquinone/plastoquinone (complex I). (527 aa)
nuoNProton-translocating NADH-quinone oxidoreductase, chain N; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 2 family. (498 aa)
Sthe_0614PFAM: Inorganic pyrophosphatase; KEGG: afl:Aflv_1056 inorganic pyrophosphatase. (156 aa)
Sthe_0631Cytochrome c oxidase, subunit I; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. (631 aa)
Sthe_0996TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; KEGG: sgr:SGR_2690 putative succinate dehydrogenase iron-sulfur subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (233 aa)
Sthe_0997KEGG: fra:Francci3_0679 succinate dehydrogenase flavoprotein subunit; TIGRFAM: succinate dehydrogenase or fumarate reductase, flavoprotein subunit; succinate dehydrogenase, flavoprotein subunit; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein. (575 aa)
Sthe_0998KEGG: fal:FRAAL1189 succinate dehydrogenase hydrophobic membrane anchor protein. (155 aa)
Sthe_0999TIGRFAM: succinate dehydrogenase, cytochrome b556 subunit; PFAM: succinate dehydrogenase cytochrome b subunit; KEGG: cmi:CMM_0972 succinate dehydrogenase, cytochrome b subunit. (121 aa)
Sthe_1238PFAM: Respiratory-chain NADH dehydrogenase domain 51 kDa subunit; KEGG: pth:PTH_2648 NADH:ubiquinone oxidoreductase, NADH-binding 51 kD subunit. (575 aa)
Sthe_1239PFAM: NADH dehydrogenase (ubiquinone) 24 kDa subunit; KEGG: tko:TK1614 NADH dehydrogenase subunit E. (180 aa)
atpCATP synthase F1, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (149 aa)
atpDATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (469 aa)
atpGATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (289 aa)
atpAATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (507 aa)
atpHATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (177 aa)
atpFATP synthase F0, B subunit; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (167 aa)
atpEATP synthase F0, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (81 aa)
atpBATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (279 aa)
Sthe_1582Cytochrome c oxidase, subunit II; Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). (345 aa)
Sthe_1583Cytochrome c oxidase, subunit I; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. (611 aa)
Sthe_1585KEGG: sth:STH2099 hypothetical protein. (102 aa)
nuoINADH-quinone oxidoreductase, chain I; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (148 aa)
Sthe_1654PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: cau:Caur_3358 FAD-dependent pyridine nucleotide-disulphide oxidoreductase. (451 aa)
Sthe_1835PFAM: cytochrome c oxidase subunit II; KEGG: rrs:RoseRS_0933 cytochrome c oxidase, subunit II. (160 aa)
Sthe_1836PFAM: cytochrome c oxidase subunit I; KEGG: cau:Caur_2426 cytochrome-c oxidase; Belongs to the heme-copper respiratory oxidase family. (554 aa)
Sthe_2052PFAM: cytochrome c oxidase subunit II; blue (type 1) copper domain protein; KEGG: rrs:RoseRS_0933 cytochrome c oxidase, subunit II. (155 aa)
Sthe_2053PFAM: cytochrome c oxidase subunit I; KEGG: cau:Caur_2426 cytochrome-c oxidase; Belongs to the heme-copper respiratory oxidase family. (561 aa)
Sthe_2934PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: reh:H16_A1815 putative NADH dehydrogenase. (451 aa)
Sthe_3102PFAM: cytochrome oxidase assembly; KEGG: gur:Gura_0405 cytochrome oxidase assembly. (326 aa)
Sthe_3163PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; FAD dependent oxidoreductase; KEGG: bja:blr2205 putative dehydrogenase. (406 aa)
ctaBProtoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (599 aa)
Sthe_3191PFAM: cytochrome c oxidase subunit II; KEGG: rso:RS02212 putative cytochrome c oxidase polypeptide II oxidoreductase protein. (183 aa)
Sthe_3192PFAM: cytochrome c oxidase subunit I; KEGG: bra:BRADO2260 putative cytochrome-c oxidase subunit I. (579 aa)
Sthe_3193PFAM: cytochrome oxidase assembly; KEGG: aeh:Mlg_0300 cytochrome oxidase assembly. (317 aa)
Your Current Organism:
Sphaerobacter thermophilus
NCBI taxonomy Id: 479434
Other names: S. thermophilus DSM 20745, Sphaerobacter thermophilus DSM 20745, Sphaerobacter thermophilus str. DSM 20745, Sphaerobacter thermophilus strain DSM 20745
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