STRINGSTRING
Sthe_0409 Sthe_0409 Sthe_0502 Sthe_0502 pfp pfp Sthe_1002 Sthe_1002 mdh mdh glyA glyA pfkA pfkA Sthe_1515 Sthe_1515 acsA acsA Sthe_1651 Sthe_1651 gpmI gpmI eno eno Sthe_2025 Sthe_2025 Sthe_2064 Sthe_2064 Sthe_2316 Sthe_2316 Sthe_2381 Sthe_2381 Sthe_2474 Sthe_2474 Sthe_2475 Sthe_2475 Sthe_2476 Sthe_2476 Sthe_2500 Sthe_2500 fbiD fbiD Sthe_2613 Sthe_2613 Sthe_2817 Sthe_2817 Sthe_2818 Sthe_2818 Sthe_2819 Sthe_2819 Sthe_2879 Sthe_2879 Sthe_3385 Sthe_3385 Sthe_3388 Sthe_3388 Sthe_3389 Sthe_3389 Sthe_3425 Sthe_3425 Sthe_3523 Sthe_3523
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
Sthe_0409PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; KEGG: tpd:Teth39_2066 D-isomer specific 2- hydroxyacid dehydrogenase, NAD-binding. (318 aa)
Sthe_0502Hydroxypyruvate reductase; PFAM: MOFRL domain protein; KEGG: cau:Caur_0619 hydroxypyruvate reductase. (439 aa)
pfpPhosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (402 aa)
Sthe_1002TIGRFAM: fructose-1,6-bisphosphatase, class II; PFAM: GlpX family protein; KEGG: tfu:Tfu_0464 fructose 1,6-bisphosphatase II. (328 aa)
mdhMalate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (308 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (422 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (374 aa)
Sthe_1515PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; KEGG: rca:Rcas_0263 D-3-phosphoglycerate dehydrogenase. (316 aa)
acsAacetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (659 aa)
Sthe_1651PFAM: molybdopterin oxidoreductase; ferredoxin; 4Fe- 4S ferredoxin iron-sulfur binding domain protein; molybdopterin oxidoreductase Fe4S4 region; KEGG: chy:CHY_0733 NAD-dependent formate dehydrogenase, alpha subunit, selenocysteine-containing. (798 aa)
gpmIPhosphoglycerate mutase, 2,3-bisphosphoglycerate- independent; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (519 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (433 aa)
Sthe_2025PFAM: AMP-dependent synthetase and ligase; KEGG: pcl:Pcal_0155 AMP-dependent synthetase and ligase. (641 aa)
Sthe_2064Citryl-CoA lyase; PFAM: HpcH/HpaI aldolase; KEGG: rxy:Rxyl_2830 citryl-CoA lyase; Belongs to the HpcH/HpaI aldolase family. (304 aa)
Sthe_2316PFAM: Luciferase-like monooxygenase; KEGG: mtp:Mthe_0205 methylenetetrahydromethanopterin reductase. (359 aa)
Sthe_2381PFAM: AMP-dependent synthetase and ligase; KEGG: sth:STH1025 acetyl-coenzyme A synthetase. (657 aa)
Sthe_2474PFAM: molybdopterin oxidoreductase Fe4S4 region; KEGG: gbm:Gbem_2182 molybdopterin oxidoreductase Fe4s4 region. (178 aa)
Sthe_2475Nitrate reductase; PFAM: molydopterin dinucleotide-binding region; molybdopterin oxidoreductase; KEGG: ank:AnaeK_0872 formate dehydrogenase, alpha subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (863 aa)
Sthe_2476PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: afw:Anae109_0861 4Fe-4S ferredoxin iron- sulfur binding domain-containing protein. (290 aa)
Sthe_2500TIGRFAM: F420-dependent oxidoreductase; PFAM: protein of unknown function DUF129; KEGG: cps:CPS_4045 putative F420-dependent oxidoreductase. (251 aa)
fbiD2-phospho-L-lactate guanylyltransferase CofC; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor. (207 aa)
Sthe_2613TIGRFAM: LPPG domain protein containing protein; PFAM: protein of unknown function UPF0052 and CofD; KEGG: eba:p2A344 LPPG:FO 2-phospho-L-lactate transferase. (325 aa)
Sthe_2817PFAM: PEP-utilising protein mobile region; KEGG: gme:Gmet_2100 hypothetical protein. (605 aa)
Sthe_2818PFAM: pyruvate phosphate dikinase PEP/pyruvate- binding; KEGG: gme:Gmet_2101 pyruvate phosphate dikinase, PEP/pyruvate-binding. (358 aa)
Sthe_2819PFAM: PEP-utilising protein mobile region; KEGG: bbt:BBta_1604 hypothetical protein. (606 aa)
Sthe_2879PFAM: Luciferase-like, subgroup; KEGG: cps:CPS_4043 methylenetetrahydromethanopterin reductase. (329 aa)
Sthe_3385PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: reu:Reut_B5201 zinc-containing alcohol dehydrogenase superfamily protein. (359 aa)
Sthe_3388Contains selenocysteine; TIGRFAM: formate dehydrogenase, alpha subunit; PFAM: molybdopterin oxidoreductase Fe4S4 region; molybdopterin oxidoreductase; molydopterin dinucleotide- binding region; KEGG: ank:AnaeK_0872 formate dehydrogenase, alpha subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1088 aa)
Sthe_3389PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: acp:A2cp1_0875 4Fe-4S ferredoxin iron-sulfur binding domain protein. (282 aa)
Sthe_3425PFAM: Alcohol dehydrogenase GroES domain protein; Alcohol dehydrogenase zinc-binding domain protein; KEGG: afw:Anae109_0561 alcohol dehydrogenase. (401 aa)
Sthe_3523PFAM: AMP-dependent synthetase and ligase; KEGG: dal:Dalk_0007 AMP-dependent synthetase and ligase. (552 aa)
Your Current Organism:
Sphaerobacter thermophilus
NCBI taxonomy Id: 479434
Other names: S. thermophilus DSM 20745, Sphaerobacter thermophilus DSM 20745, Sphaerobacter thermophilus str. DSM 20745, Sphaerobacter thermophilus strain DSM 20745
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