STRINGSTRING
dnaG dnaG Sthe_0458 Sthe_0458 rnhB rnhB Sthe_0516 Sthe_0516 Sthe_0659 Sthe_0659 ligA ligA Sthe_0940 Sthe_0940 Sthe_1214 Sthe_1214 Sthe_1301 Sthe_1301 Sthe_1312 Sthe_1312 Sthe_1450 Sthe_1450 polA polA Sthe_1596 Sthe_1596 dnaX dnaX Sthe_2275 Sthe_2275
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (615 aa)
Sthe_0458KEGG: cur:cur_1297 hypothetical protein. (139 aa)
rnhBRibonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (233 aa)
Sthe_0516PFAM: DNA polymerase B region; DNA polymerase B exonuclease; SMART: DNA-directed DNA polymerase B; KEGG: gsu:GSU3245 DNA polymerase II, putative. (730 aa)
Sthe_0659TIGRFAM: DNA polymerase III, delta prime subunit; KEGG: rrs:RoseRS_3588 DNA polymerase III, delta prime subunit. (346 aa)
ligADNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (680 aa)
Sthe_0940KEGG: sru:SRU_1441 hypothetical protein; TIGRFAM: DNA polymerase III, epsilon subunit; PFAM: Exonuclease RNase T and DNA polymerase III; Excinuclease ABC C subunit domain protein; UvrB/UvrC protein; SMART: Exonuclease; Excinuclease ABC C subunit domain protein. (658 aa)
Sthe_1214TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III delta; KEGG: cau:Caur_2419 DNA polymerase III, delta subunit. (340 aa)
Sthe_1301KEGG: det:DET1464 DNA polymerase III, alpha subunit; TIGRFAM: DNA polymerase III, alpha subunit; PFAM: DNA polymerase III alpha subunit; PHP domain protein; nucleic acid binding OB-fold tRNA/helicase-type; SMART: phosphoesterase PHP domain protein. (1167 aa)
Sthe_1312DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (379 aa)
Sthe_1450TIGRFAM: single-strand binding protein; PFAM: single-strand binding protein/Primosomal replication protein n; nucleic acid binding OB-fold tRNA/helicase-type; KEGG: cau:Caur_0870 single-strand binding protein. (148 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (915 aa)
Sthe_1596Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (447 aa)
dnaXDNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (589 aa)
Sthe_2275PFAM: Exonuclease RNase T and DNA polymerase III; SMART: Exonuclease; KEGG: hch:HCH_06756 putative exonuclease. (335 aa)
Your Current Organism:
Sphaerobacter thermophilus
NCBI taxonomy Id: 479434
Other names: S. thermophilus DSM 20745, Sphaerobacter thermophilus DSM 20745, Sphaerobacter thermophilus str. DSM 20745, Sphaerobacter thermophilus strain DSM 20745
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