STRINGSTRING
Kfla_0206 Kfla_0206 Kfla_1370 Kfla_1370 Kfla_1839 Kfla_1839 arc arc Kfla_3224 Kfla_3224 pup pup prcB prcB prcA prcA Kfla_3669 Kfla_3669 Kfla_4885 Kfla_4885 pafA pafA Kfla_5478 Kfla_5478 Kfla_6887 Kfla_6887
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Kfla_0206Hypothetical protein. (202 aa)
Kfla_1370PFAM: peptidase S1 and S6 chymotrypsin/Hap; KEGG: mxa:MXAN_4433 S1C family peptidase. (320 aa)
Kfla_1839PFAM: Mov34/MPN/PAD-1 family protein; SMART: Mov34/MPN/PAD-1 family protein; KEGG: nmu:Nmul_A0971 Mov34/MPN/PAD-1. (153 aa)
arcAAA ATPase central domain protein; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. (578 aa)
Kfla_3224PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein. (506 aa)
pupProtein of unknown function DUF797; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. Belongs to the prokaryotic ubiquitin-like protein family. (69 aa)
prcB20S proteasome A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. (279 aa)
prcA20S proteasome A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. (283 aa)
Kfla_3669PFAM: AAA ATPase central domain protein; SMART: AAA ATPase; KEGG: mex:Mext_2172 ATPase central domain- containing protein. (457 aa)
Kfla_4885Hypothetical protein; KEGG: mex:Mext_1393 peptidoglycan binding domain- containing protein. (419 aa)
pafAProtein of unknown function DUF245 domain protein; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. (453 aa)
Kfla_5478PFAM: PDZ/DHR/GLGF domain protein; peptidase S1 and S6 chymotrypsin/Hap; SMART: PDZ/DHR/GLGF domain protein; KEGG: pzu:PHZ_c1087 serine protease HtrA. (524 aa)
Kfla_6887PFAM: PDZ/DHR/GLGF domain protein; peptidase S1 and S6 chymotrypsin/Hap; SMART: PDZ/DHR/GLGF domain protein; KEGG: nam:NAMH_0044 serine protease. (479 aa)
Your Current Organism:
Kribbella flavida
NCBI taxonomy Id: 479435
Other names: K. flavida DSM 17836, Kribbella flavida DSM 17836, Kribbella flavida str. DSM 17836, Kribbella flavida strain DSM 17836
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