STRINGSTRING
AOW45671.1 AOW45671.1 AOW45672.1 AOW45672.1 AOW45762.1 AOW45762.1 AOW45763.1 AOW45763.1 aat aat hslV hslV AOW45922.1 AOW45922.1 AOW45923.1 AOW45923.1 AOW45948.1 AOW45948.1 AOW46200.1 AOW46200.1 lon lon clpX clpX clpP clpP clpB clpB groS groS groL groL clpP-2 clpP-2 htpG htpG dnaJ dnaJ dnaK dnaK grpE grpE AOW47239.1 AOW47239.1 clpS clpS AOW47373.1 AOW47373.1 hrcA hrcA AOW47594.1 AOW47594.1 AOW47595.1 AOW47595.1 AOW47596.1 AOW47596.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AOW45671.1Heat-shock protein Hsp33; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress; Belongs to the HSP33 family. (316 aa)
AOW45672.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (105 aa)
AOW45762.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (170 aa)
AOW45763.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (104 aa)
aatleucyl/phenylalanyl-tRNA--protein transferase; Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl- tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine. (217 aa)
hslVHslU--HslV peptidase proteolytic subunit; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. (199 aa)
AOW45922.1HslU--HslV peptidase ATPase subunit; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. (437 aa)
AOW45923.1Fe-S cluster assembly protein SufE; Derived by automated computational analysis using gene prediction method: Protein Homology. (147 aa)
AOW45948.1Heat-shock protein Hsp20; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the small heat shock protein (HSP20) family. (168 aa)
AOW46200.1Molecular chaperone DnaK; Derived by automated computational analysis using gene prediction method: Protein Homology. (438 aa)
lonEndopeptidase La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (841 aa)
clpXATP-dependent protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (421 aa)
clpPATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (217 aa)
clpBATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (871 aa)
groSCo-chaperone GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (97 aa)
groLChaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (543 aa)
clpP-2ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (215 aa)
htpGMolecular chaperone HtpG; Molecular chaperone. Has ATPase activity. (625 aa)
dnaJMolecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] (380 aa)
dnaKMolecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (634 aa)
grpENucleotide exchange factor GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds [...] (198 aa)
AOW47239.1ATP-dependent Clp protease ATP-binding subunit ClpA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ClpA/ClpB family. (781 aa)
clpSATP-dependent Clp protease adapter ClpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. (110 aa)
AOW47373.1Molecular chaperone DnaJ; Derived by automated computational analysis using gene prediction method: Protein Homology. (305 aa)
hrcAHeat-inducible transcriptional repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. (357 aa)
AOW47594.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (322 aa)
AOW47595.1Clp protease; Derived by automated computational analysis using gene prediction method: Protein Homology. (427 aa)
AOW47596.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (198 aa)
Your Current Organism:
Acetobacter ascendens
NCBI taxonomy Id: 481146
Other names: A. ascendens, Acetobacter pasteurianus subsp. ascendens, Acetobacter pasteurianus subsp. paradoxus, Bacterium ascendans, CCUG 18128, LMD 51.1, LMD 53.6 [[Acetobacter pasteurianus subsp. paradoxus]], NCCB 51001, NCCB 53006 [[Acetobacter pasteurianus subsp. paradoxus]]
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