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| | atpF | ATP synthase F0, B subunit; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (162 aa) |
| | atpA | ATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (504 aa) |
| | atpG | ATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (286 aa) |
| | atpD | ATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (466 aa) |
| | atpC | ATP synthase F1, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (134 aa) |
| | murA-3 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (449 aa) |
| | fabZ | Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (143 aa) |
| | ACX68096.1 | Glycosyl transferase, WecB/TagA/CpsF family; Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid. (252 aa) |
| | ACX68023.1 | PFAM: O-antigen polymerase; KEGG: pth:PTH_2583 hypothetical protein. (819 aa) |
| | ACX68019.1 | KEGG: mpl:Mpal_2176 hypothetical protein. (693 aa) |
| | ACX68017.1 | N-acetylglucosamine-1-phosphate uridyltransferase; KEGG: gbm:Gbem_1609 WxcM domain protein. (188 aa) |
| | ACX68012.1 | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (182 aa) |
| | ACX68010.1 | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. (292 aa) |
| | ACX68009.1 | PFAM: glycosyl transferase family 2; KEGG: cbe:Cbei_4758 glycosyl transferase family protein. (303 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (214 aa) |
| | dacA | Protein of unknown function DUF147; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (277 aa) |
| | glmS | Glucosamine/fructose-6-phosphate aminotransferase, isomerizing; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (610 aa) |
| | deoB | Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (392 aa) |
| | ACX67793.1 | KEGG: lsp:Bsph_2622 hypothetical protein. (204 aa) |
| | ACX67683.1 | Peptidoglycan glycosyltransferase; PFAM: penicillin-binding protein transpeptidase; Penicillin-binding protein dimerisation domain; KEGG: pjd:Pjdr2_4869 peptidoglycan glycosyltransferase. (684 aa) |
| | ACX67642.1 | PFAM: metallophosphoesterase; Twin-arginine translocation pathway, signal sequence, subgroup; KEGG: bbe:BBR47_23550 hypothetical protein. (302 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (426 aa) |
| | ACX67567.1 | PFAM: Monogalactosyldiacylglycerol synthase; KEGG: pjd:Pjdr2_5001 monogalactosyldiacylglycerol synthase. (391 aa) |
| | ACX67551.1 | PFAM: lipopolysaccharide biosynthesis protein; KEGG: pjd:Pjdr2_0399 lipopolysaccharide biosynthesis protein. (253 aa) |
| | fcl | NAD-dependent epimerase/dehydratase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. (319 aa) |
| | ACX67544.1 | PFAM: glycosyl transferase family 2; KEGG: rce:RC1_0655 glycosyl transferase, family 2, putative. (282 aa) |
| | uppP-4 | Undecaprenyl-diphosphatase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (270 aa) |
| | purU | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (312 aa) |
| | ACX67406.1 | KEGG: sab:SAB2251c hypothetical protein. (136 aa) |
| | ACX67361.1 | PFAM: Monogalactosyldiacylglycerol synthase; Glycosyltransferase 28 domain; KEGG: pjd:Pjdr2_5001 monogalactosyldiacylglycerol synthase. (375 aa) |
| | ACX67196.1 | PFAM: acyltransferase 3; KEGG: pjd:Pjdr2_2790 acyltransferase 3. (735 aa) |
| | uppP-3 | Undecaprenol kinase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (274 aa) |
| | accD | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (297 aa) |
| | accA | acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (327 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (199 aa) |
| | ACX66987.1 | PFAM: NAD-dependent epimerase/dehydratase; dTDP-4-dehydrorhamnose reductase; KEGG: pjd:Pjdr2_1960 NAD-dependent epimerase/dehydratase. (284 aa) |
| | ACX66976.1 | PFAM: NAD-dependent epimerase/dehydratase; KEGG: pjd:Pjdr2_6189 NAD-dependent epimerase/dehydratase. (358 aa) |
| | ddl-2 | D-alanine/D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (305 aa) |
| | murI-2 | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (268 aa) |
| | ACX66852.1 | PFAM: sulfatase; KEGG: pjd:Pjdr2_2091 sulfatase; Belongs to the LTA synthase family. (661 aa) |
| | ACX66811.1 | PFAM: ErfK/YbiS/YcfS/YnhG family protein; KEGG: ckr:CKR_1939 hypothetical protein. (468 aa) |
| | pyrD-2 | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (370 aa) |
| | ACX66808.1 | PFAM: RelA/SpoT domain protein; KEGG: pjd:Pjdr2_2152 RelA/SpoT domain protein. (270 aa) |
| | xpt-2 | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (189 aa) |
| | ACX66709.1 | Peptidoglycan glycosyltransferase; PFAM: penicillin-binding protein transpeptidase; Penicillin-binding protein dimerisation domain; KEGG: pjd:Pjdr2_4869 peptidoglycan glycosyltransferase. (680 aa) |
| | ACX66681.1 | PFAM: LmbE family protein; KEGG: dfe:Dfer_1152 LmbE family protein. (278 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (214 aa) |
| | glmU | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (464 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (317 aa) |
| | ACX62364.1 | KEGG: pjd:Pjdr2_0062 hypoxanthine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (179 aa) |
| | coaX | Putative transcriptional acitvator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (254 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (485 aa) |
| | ACX62385.1 | Serine-type D-Ala-D-Ala carboxypeptidase; PFAM: peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; Penicillin-binding protein 5 domain protein; KEGG: pjd:Pjdr2_0090 serine-type D-Ala-D-Ala carboxypeptidase; Belongs to the peptidase S11 family. (472 aa) |
| | ACX62424.1 | PFAM: phosphoesterase PA-phosphatase related; SMART: phosphoesterase PA-phosphatase related; KEGG: pjd:Pjdr2_1285 phosphoesterase PA-phosphatase related. (174 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (533 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (419 aa) |
| | prs-2 | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (316 aa) |
| | pyrD | Dihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate. (310 aa) |
| | ACX62711.1 | PFAM: Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain; oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein; KEGG: cdf:CD0185 dihydroorotate dehydrogenase electron transfer subunit. (233 aa) |
| | ACX62740.1 | TIGRFAM: uridine kinase; PFAM: phosphoribulokinase/uridine kinase; KEGG: pjd:Pjdr2_1887 uridine kinase. (212 aa) |
| | ACX62812.1 | PFAM: NAD-dependent epimerase/dehydratase; KEGG: phe:Phep_1690 NAD-dependent epimerase/dehydratase. (338 aa) |
| | ACX62892.1 | Hypothetical protein; KEGG: cbe:Cbei_3776 glycosyl transferase family protein. (375 aa) |
| | ACX62965.1 | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (343 aa) |
| | ACX63025.1 | PFAM: metallophosphoesterase; KEGG: aoe:Clos_0823 metallophosphoesterase. (367 aa) |
| | xpt | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (189 aa) |
| | murI | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (258 aa) |
| | ACX66664.1 | PFAM: protein of unknown function UPF0157; KEGG: bca:BCE_2673 hypothetical protein. (171 aa) |
| | ACX66564.1 | Peptidoglycan glycosyltransferase; PFAM: penicillin-binding protein transpeptidase; Penicillin-binding protein dimerisation domain; KEGG: pjd:Pjdr2_4869 peptidoglycan glycosyltransferase. (693 aa) |
| | amj | Conserved hypothetical protein; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. (263 aa) |
| | coaD | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (171 aa) |
| | ACX66455.1 | KEGG: pjd:Pjdr2_3482 hypothetical protein; Belongs to the UPF0109 family. (76 aa) |
| | ACX66415.1 | KEGG: pjd:Pjdr2_3454 ATPase, FliI/YscN family; TIGRFAM: flagellar protein export ATPase FliI; ATPase, FliI/YscN family; PFAM: H+transporting two-sector ATPase alpha/beta subunit central region; H+transporting two-sector ATPase alpha/beta subunit domain protein; SMART: AAA ATPase. (439 aa) |
| | ACX66385.1 | KEGG: pjd:Pjdr2_3422 hypothetical protein. (204 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (242 aa) |
| | ACX66366.1 | TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: FAD synthetase; Riboflavin kinase; KEGG: pjd:Pjdr2_3403 riboflavin biosynthesis protein RibF; Belongs to the ribF family. (317 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (148 aa) |
| | ACX66229.1 | KEGG: cpy:Cphy_2386 uridine kinase. (193 aa) |
| | murB-2 | UDP-N-acetylmuramate dehydrogenase; Cell wall formation. (343 aa) |
| | murE-2 | UDP-N-acetylmuramyl-tripeptide synthetase; Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. (502 aa) |
| | ACX66072.1 | PFAM: RelA/SpoT domain protein; KEGG: pjd:Pjdr2_5952 RelA/SpoT domain protein. (247 aa) |
| | araB-2 | TIGRFAM: L-ribulokinase; PFAM: Carbohydrate kinase, FGGY-like; KEGG: gtn:GTNG_1796 ribulokinase. (566 aa) |
| | ACX66011.1 | PFAM: H+transporting two-sector ATPase alpha/beta subunit domain protein; KEGG: pjd:Pjdr2_4713 F0F1-type ATP synthase beta subunit-like protein. (348 aa) |
| | ACX65969.1 | PFAM: phosphoesterase PA-phosphatase related; SMART: phosphoesterase PA-phosphatase related; KEGG: afl:Aflv_0415 membrane-associated phospholipid phosphatase. (178 aa) |
| | ACX65968.1 | PFAM: Monogalactosyldiacylglycerol synthase; glycosyl transferase group 1; Glycosyltransferase 28 domain; KEGG: dhd:Dhaf_3178 monogalactosyldiacylglycerol synthase. (413 aa) |
| | ACX65956.1 | KEGG: pjd:Pjdr2_0935 hypothetical protein. (114 aa) |
| | ACX65955.1 | PFAM: LmbE family protein; KEGG: pjd:Pjdr2_0936 LmbE family protein. (218 aa) |
| | dacB | Protein of unknown function DUF147; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (205 aa) |
| | purT | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (386 aa) |
| | ACX65555.1 | Uridine kinase-like protein; KEGG: bcr:BCAH187_A2829 putative uridine kinase. (209 aa) |
| | uppP-2 | Undecaprenol kinase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (267 aa) |
| | ACX65346.1 | PFAM: protein of unknown function UPF0157; KEGG: cbk:CLL_A2139 protein YqkA. (171 aa) |
| | ACX64796.1 | KEGG: bcl:ABC0288 topology modulation protein. (169 aa) |
| | mraY-2 | Phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (319 aa) |
| | ACX64764.1 | PFAM: sulfatase; KEGG: pjd:Pjdr2_1197 sulfatase; Belongs to the LTA synthase family. (641 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (402 aa) |
| | ACX64513.1 | PFAM: LmbE family protein; KEGG: pjd:Pjdr2_2441 LmbE family protein. (235 aa) |
| | ndk | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (150 aa) |
| | gpsA | PFAM: NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; NADP oxidoreductase coenzyme F420-dependent; KEGG: pjd:Pjdr2_2392 glycerol-3-phosphate dehydrogenase (NAD(P)(+)); Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (346 aa) |
| | ACX64452.1 | PFAM: metallophosphoesterase; KEGG: afl:Aflv_1064 calcineurin-like phosphohydrolase. (272 aa) |
| | ACX64439.1 | PFAM: peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; beta-lactamase; KEGG: pjd:Pjdr2_2360 peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; Belongs to the peptidase S11 family. (394 aa) |
| | ACX64421.1 | Serine-type D-Ala-D-Ala carboxypeptidase; PFAM: peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; Penicillin-binding protein 5 domain protein; KEGG: pjd:Pjdr2_2338 serine-type D-Ala-D-Ala carboxypeptidase; Belongs to the peptidase S11 family. (396 aa) |
| | ACX64402.1 | PFAM: NAD-dependent epimerase/dehydratase; KEGG: bbe:BBR47_36740 hypothetical protein. (295 aa) |
| | dxs | Deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (635 aa) |
| | ACX64381.1 | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (447 aa) |
| | ACX64230.1 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (418 aa) |
| | ACX64179.1 | PFAM: GCN5-related N-acetyltransferase; KEGG: aac:Aaci_0878 GCN5-related N-acetyltransferase. (147 aa) |
| | ACX64163.1 | PFAM: ErfK/YbiS/YcfS/YnhG family protein; KEGG: cdf:CD2713 cell surface protein. (102 aa) |
| | ACX64149.1 | PFAM: ErfK/YbiS/YcfS/YnhG family protein; KEGG: pjd:Pjdr2_3504 ErfK/YbiS/YcfS/YnhG family protein. (112 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (213 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (245 aa) |
| | carB | TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; protein of unknown function DUF201; RimK domain protein ATP-grasp; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; MGS domain protein; Carbamoyl-phosphate synthetase large chain oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; KEGG: pjd:Pjdr2_3861 carbamoyl-phosphate synthase, large subunit; Belongs to the CarB family. (1068 aa) |
| | carA | TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase small chain; glutamine amidotransferase class-I; KEGG: pjd:Pjdr2_3862 carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (378 aa) |
| | pyrC | Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (433 aa) |
| | pyrB | KEGG: pjd:Pjdr2_3864 aspartate carbamoyltransferase; TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (302 aa) |
| | murA-2 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (427 aa) |
| | murB | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (301 aa) |
| | murG | Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (369 aa) |
| | murD | UDP-N-acetylmuramoylalanine/D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (477 aa) |
| | mraY | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (321 aa) |
| | murF | UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate/D-alanyl-D-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (473 aa) |
| | murE | UDP-N-acetylmuramyl-tripeptide synthetase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (494 aa) |
| | ACX64094.1 | KEGG: pjd:Pjdr2_3895 stage V sporulation protein D; TIGRFAM: stage V sporulation protein D; PFAM: penicillin-binding protein transpeptidase; PASTA domain containing protein; Penicillin-binding protein dimerisation domain; SMART: PASTA domain containing protein. (647 aa) |
| | araB | TIGRFAM: L-ribulokinase; PFAM: Carbohydrate kinase, FGGY-like; KEGG: gtn:GTNG_1796 ribulokinase. (556 aa) |
| | ACX63923.1 | TIGRFAM: L-ribulose-5-phosphate 4-epimerase; PFAM: class II aldolase/adducin family protein; KEGG: pjd:Pjdr2_4207 L-ribulose-5-phosphate 4-epimerase. (229 aa) |
| | araA | L-arabinose isomerase; Catalyzes the conversion of L-arabinose to L-ribulose. (495 aa) |
| | ACX63890.1 | Peptidoglycan glycosyltransferase; PFAM: penicillin-binding protein transpeptidase; Penicillin-binding protein dimerisation domain; KEGG: pjd:Pjdr2_4338 penicillin-binding protein transpeptidase. (596 aa) |
| | mltG | Aminodeoxychorismate lyase; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. (347 aa) |
| | ACX63870.1 | Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (167 aa) |
| | ACX63856.1 | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (725 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (171 aa) |
| | tgt | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] (379 aa) |
| | queA | S-adenosylmethionine/tRNA-ribosyltransferase- isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (343 aa) |
| | murC | UDP-N-acetylmuramate/alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (458 aa) |
| | ACX63752.1 | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (185 aa) |
| | ACX63751.1 | PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; protein of unknown function DUF201; ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; KEGG: apr:Apre_1268 phosphoribosylglycinamide synthetase. (391 aa) |
| | ACX63742.1 | PFAM: glycosyl transferase family 2; KEGG: pjd:Pjdr2_3517 glycosyl transferase family 2. (356 aa) |
| | ACX63741.1 | PFAM: glycosyl transferase family 2; KEGG: pjd:Pjdr2_1431 glycosyl transferase family 2. (279 aa) |
| | queC | exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). (225 aa) |
| | ACX63712.1 | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: bcz:BCZK1233 6-pyruvoyl tetrahydrobiopterin synthase. (163 aa) |
| | queE | 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (243 aa) |
| | queF | 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. (165 aa) |
| | ACX63492.1 | PFAM: protein of unknown function UPF0157; KEGG: bsu:BSU23670 hypothetical protein. (175 aa) |
| | ACX63471.1 | PFAM: NAD-dependent epimerase/dehydratase; NmrA family protein; KEGG: bbe:BBR47_33200 hypothetical protein. (318 aa) |
| | ACX63308.1 | PFAM: membrane bound O-acyl transferase MBOAT family protein; KEGG: eat:EAT1b_1059 membrane bound O-acyl transferase MBOAT family protein; Belongs to the membrane-bound acyltransferase family. (397 aa) |
| | ACX63254.1 | PFAM: LmbE family protein; KEGG: tte:TTE0219 hypothetical protein. (235 aa) |
| | purD | KEGG: pjd:Pjdr2_0871 phosphoribosylamine/glycine ligase; TIGRFAM: phosphoribosylamine/glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; Belongs to the GARS family. (422 aa) |
| | purH | KEGG: pjd:Pjdr2_0870 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme formylation region; MGS domain protein; SMART: AICARFT/IMPCHase bienzyme formylation region. (515 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (203 aa) |
| | purM | KEGG: pjd:Pjdr2_0868 phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein. (346 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (492 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (747 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (229 aa) |
| | purS | Phosphoribosylformylglycinamidine synthase, purS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assi [...] (81 aa) |
| | purC | PFAM: SAICAR synthetase; KEGG: pjd:Pjdr2_0863 phosphoribosylaminoimidazolesuccinocarboxamide synthase. (296 aa) |
| | ACX63237.1 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; Adenylosuccinate lyase-like; KEGG: pjd:Pjdr2_0862 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (431 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (395 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (161 aa) |
| | guaA | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (512 aa) |
| | ddl | D-alanine/D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (364 aa) |
| | ACX63156.1 | Iron-sulfur cluster binding protein; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (614 aa) |
| | uppP | Undecaprenol kinase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (280 aa) |
| | ACX68515.1 | PFAM: peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; KEGG: bha:BH0021 serine-type D-Ala-D-Ala carboxypeptidase; Belongs to the peptidase S11 family. (323 aa) |
| | purA-2 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (429 aa) |
| | ACX68416.1 | PFAM: acyltransferase 3; KEGG: bcx:BCA_5606 hypothetical protein. (363 aa) |
| | ACX68405.1 | PFAM: NAD-dependent epimerase/dehydratase; Male sterility domain; dTDP-4-dehydrorhamnose reductase; KEGG: cpy:Cphy_0710 NAD-dependent epimerase/dehydratase. (338 aa) |
| | ACX68242.1 | KEGG: lsp:Bsph_3077 hypothetical protein. (184 aa) |
| | ACX68213.1 | PFAM: sulfatase; KEGG: pjd:Pjdr2_5894 sulfatase; Belongs to the LTA synthase family. (619 aa) |
| | ACX68189.1 | PFAM: peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; KEGG: bbe:BBR47_00150 D-alanyl-D-alanine carboxypeptidase precursor; Belongs to the peptidase S11 family. (336 aa) |
| | ACX68171.1 | PFAM: NAD-dependent epimerase/dehydratase; KEGG: hsl:OE6249F hypothetical protein. (211 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa) |
| | ACX68120.1 | KEGG: pjd:Pjdr2_5827 UDP-N-acetylglucosamine 2-epimerase; TIGRFAM: UDP-N-acetylglucosamine 2-epimerase; PFAM: UDP-N-acetylglucosamine 2-epimerase; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. (385 aa) |
| | atpB | ATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (266 aa) |
| | atpE | ATP synthase F0, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (70 aa) |
| | atpH | ATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (181 aa) |
