(55 nodes) RHO GTPases Activate WASPs and WAVEs, and Actin family network (Schistosoma margrebowiei)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SMRZ_LOCUS379	Uncharacterized protein. (376 aa)
	SMRZ_LOCUS1566	Uncharacterized protein. (92 aa)
	SMRZ_LOCUS1590	Uncharacterized protein. (378 aa)
	SMRZ_LOCUS1885	Uncharacterized protein. (376 aa)
	SMRZ_LOCUS1933	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (156 aa)
	SMRZ_LOCUS1995	Uncharacterized protein. (799 aa)
	SMRZ_LOCUS2494	Uncharacterized protein. (779 aa)
	SMRZ_LOCUS2794	Uncharacterized protein. (620 aa)
	SMRZ_LOCUS3463	Transgelin; Belongs to the calponin family. (173 aa)
	SMRZ_LOCUS3567	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (166 aa)
	SMRZ_LOCUS3832	TLC domain-containing protein. (74 aa)
	SMRZ_LOCUS4142	Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (166 aa)
	SMRZ_LOCUS4546	WH1 domain-containing protein. (193 aa)
	SMRZ_LOCUS4968	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (210 aa)
	SMRZ_LOCUS5137	Uncharacterized protein. (308 aa)
	A0A183LQ62	Uncharacterized protein. (489 aa)
	SMRZ_LOCUS6916	Uncharacterized protein. (455 aa)
	A0A183LT24	WD_REPEATS_REGION domain-containing protein. (243 aa)
	A0A183LTY0	Uncharacterized protein. (415 aa)
	SMRZ_LOCUS7301	Uncharacterized protein; Belongs to the actin family. (228 aa)
	SMRZ_LOCUS8060	Uncharacterized protein. (158 aa)
	SMRZ_LOCUS8360	Uncharacterized protein. (432 aa)
	SMRZ_LOCUS8685	Uncharacterized protein. (70 aa)
	SMRZ_LOCUS8819	Uncharacterized protein; Belongs to the actin family. (372 aa)
	A0A183LZ15	Uncharacterized protein; Belongs to the actin family. (176 aa)
	SMRZ_LOCUS9187	Uncharacterized protein; Belongs to the actin family. (380 aa)
	SMRZ_LOCUS9655	DUF2013 domain-containing protein. (562 aa)
	A0A183M6N2	Uncharacterized protein. (153 aa)
	A0A183M7F3	SH3 domain-containing protein. (79 aa)
	A0A183M8T5	Uncharacterized protein. (397 aa)
	A0A183M980	Uncharacterized protein. (326 aa)
	A0A183MA09	Uncharacterized protein. (130 aa)
	A0A183MCU4	Uncharacterized protein. (98 aa)
	A0A183MD74	Calponin-homology (CH) domain-containing protein. (125 aa)
	A0A183MHV8	Uncharacterized protein. (462 aa)
	A0A183MK50	Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (140 aa)
	A0A183MLB4	Uncharacterized protein. (162 aa)
	A0A183MLX7	Uncharacterized protein. (1157 aa)
	A0A183MN20	CRIB domain-containing protein. (313 aa)
	A0A183MNH3	WD_REPEATS_REGION domain-containing protein. (188 aa)
	A0A183MNM7	Uncharacterized protein. (376 aa)
	A0A183MQH4	WH2 domain-containing protein. (240 aa)
	A0A183MR98	Uncharacterized protein. (116 aa)
	A0A183MSH5	Uncharacterized protein. (363 aa)
	A0A183MU29	Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (166 aa)
	A0A183MY15	Adenylyl cyclase-associated protein; Belongs to the CAP family. (446 aa)
	A0A183MYB7	Calponin-homology (CH) domain-containing protein. (322 aa)
	A0A183N1B1	WD_REPEATS_REGION domain-containing protein. (317 aa)
	A0A183N1B3	Uncharacterized protein. (54 aa)
	A0A183N1I1	CAP_N domain-containing protein. (236 aa)
	A0A183N2X3	ADF-H domain-containing protein. (174 aa)
	A0A183N3Q9	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (292 aa)
	A0A183N4X3	Uncharacterized protein. (227 aa)
	A0A183N7G9	Uncharacterized protein; Belongs to the actin family. (285 aa)
	A0A183N8D0	Uncharacterized protein. (379 aa)

Your Current Organism:

Schistosoma margrebowiei

NCBI taxonomy Id: 48269
Other names: S. margrebowiei

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A183LQ62	A0A183LT24	A0A183LQ62	A0A183LT24	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.633
A0A183LQ62	A0A183LZ15	A0A183LQ62	A0A183LZ15	Uncharacterized protein.	Uncharacterized protein; Belongs to the actin family.	0.736
A0A183LQ62	A0A183M7F3	A0A183LQ62	A0A183M7F3	Uncharacterized protein.	SH3 domain-containing protein.	0.941
A0A183LQ62	A0A183M980	A0A183LQ62	A0A183M980	Uncharacterized protein.	Uncharacterized protein.	0.575
A0A183LQ62	A0A183MA09	A0A183LQ62	A0A183MA09	Uncharacterized protein.	Uncharacterized protein.	0.970
A0A183LQ62	A0A183MCU4	A0A183LQ62	A0A183MCU4	Uncharacterized protein.	Uncharacterized protein.	0.941
A0A183LQ62	A0A183MK50	A0A183LQ62	A0A183MK50	Uncharacterized protein.	Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.	0.773
A0A183LQ62	A0A183MLB4	A0A183LQ62	A0A183MLB4	Uncharacterized protein.	Uncharacterized protein.	0.575
A0A183LQ62	A0A183MLX7	A0A183LQ62	A0A183MLX7	Uncharacterized protein.	Uncharacterized protein.	0.970
A0A183LQ62	A0A183MN20	A0A183LQ62	A0A183MN20	Uncharacterized protein.	CRIB domain-containing protein.	0.750
A0A183LQ62	A0A183MNM7	A0A183LQ62	A0A183MNM7	Uncharacterized protein.	Uncharacterized protein.	0.575
A0A183LQ62	A0A183MQH4	A0A183LQ62	A0A183MQH4	Uncharacterized protein.	WH2 domain-containing protein.	0.952
A0A183LQ62	A0A183MU29	A0A183LQ62	A0A183MU29	Uncharacterized protein.	Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	0.803
A0A183LQ62	A0A183N3Q9	A0A183LQ62	A0A183N3Q9	Uncharacterized protein.	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	0.676
A0A183LQ62	A0A183N4X3	A0A183LQ62	A0A183N4X3	Uncharacterized protein.	Uncharacterized protein.	0.633
A0A183LQ62	A0A183N7G9	A0A183LQ62	A0A183N7G9	Uncharacterized protein.	Uncharacterized protein; Belongs to the actin family.	0.575
A0A183LQ62	A0A183N8D0	A0A183LQ62	A0A183N8D0	Uncharacterized protein.	Uncharacterized protein.	0.952
A0A183LQ62	SMRZ_LOCUS1566	A0A183LQ62	A0A183LCP1	Uncharacterized protein.	Uncharacterized protein.	0.987
A0A183LQ62	SMRZ_LOCUS1590	A0A183LQ62	A0A183LCR5	Uncharacterized protein.	Uncharacterized protein.	0.545
A0A183LQ62	SMRZ_LOCUS1885	A0A183LQ62	A0A183LDL0	Uncharacterized protein.	Uncharacterized protein.	0.575