STRINGSTRING
lepA lepA typA typA tetM tetM fusA fusA prfC prfC fusA_1 fusA_1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
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experimentally determined
Predicted Interactions
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gene fusions
gene co-occurrence
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textmining
co-expression
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Your Input:
lepAGTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (594 aa)
typAGTP-binding protein TypA; KEGG: bur:Bcep18194_A4648 2.2e-168 typA; GTP-binding protein TypA K06207; Psort location: Cytoplasmic, score: 9.97. (599 aa)
tetMKEGG: tel:tlr1749 7.9e-68 fus; translation elongation factor EF-G K02355; Psort location: Cytoplasmic, score: 9.26. (641 aa)
fusATranslation elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 s [...] (705 aa)
prfCPeptide chain release factor 3; Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily. (524 aa)
fusA_1KEGG: bfs:BF3636 0. putative elongation factor G K02355; Psort location: Cytoplasmic, score: 9.26. (718 aa)
Your Current Organism:
Bacteroides eggerthii
NCBI taxonomy Id: 483216
Other names: B. eggerthii DSM 20697, Bacteroides eggerthii ATCC 27754, Bacteroides eggerthii DSM 20697, Bacteroides eggerthii str. DSM 20697, Bacteroides eggerthii strain DSM 20697
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