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glyA glyA hemA hemA hemC hemC THA_1078 THA_1078 hemB hemB THA_1080 THA_1080 hemL hemL THA_1096 THA_1096 THA_1099 THA_1099 arcC arcC glpX glpX THA_1150 THA_1150 THA_1204 THA_1204 THA_125 THA_125 glnA1 glnA1 pfkB pfkB lysA lysA THA_1332 THA_1332 THA_1335 THA_1335 mgsA mgsA pgi pgi THA_1415 THA_1415 THA_1416 THA_1416 THA_1417 THA_1417 THA_1419 THA_1419 THA_1440 THA_1440 THA_1441 THA_1441 THA_1442 THA_1442 THA_1446 THA_1446 THA_1470 THA_1470 cysK cysK THA_1477 THA_1477 ldh ldh THA_155 THA_155 THA_156 THA_156 rpiB rpiB tpiA tpiA THA_1607 THA_1607 ackA ackA THA_1613 THA_1613 thrC thrC THA_1683 THA_1683 THA_170 THA_170 dapF dapF dapA dapA apgM apgM dapB dapB THA_175 THA_175 THA_176 THA_176 pfkA pfkA tal tal glnA2 glnA2 THA_1858 THA_1858 THA_1860 THA_1860 THA_188 THA_188 THA_190 THA_190 THA_191 THA_191 THA_192 THA_192 THA_1929 THA_1929 THA_196 THA_196 THA_1977 THA_1977 THA_1978 THA_1978 folD folD THA_243 THA_243 THA_244 THA_244 THA_26 THA_26 THA_302 THA_302 porG porG THA_335 THA_335 vorB vorB THA_337 THA_337 serA serA ppdK ppdK prs prs THA_402 THA_402 eno eno THA_425 THA_425 THA_518 THA_518 THA_519 THA_519 THA_520 THA_520 THA_521 THA_521 THA_53 THA_53 lpdA lpdA THA_550 THA_550 fhs fhs THA_730 THA_730 THA_762 THA_762 THA_847 THA_847 pfp pfp THA_956 THA_956 THA_96 THA_96 THA_97 THA_97
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (424 aa)
hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (372 aa)
hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (280 aa)
THA_1078Uroporphyrinogen III synthase/methyltransferase; Belongs to the precorrin methyltransferase family. (462 aa)
hemBDelta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (318 aa)
THA_1080Siroheme synthase. (148 aa)
hemLGlutamate-1-semialdehyde-2,1-aminomutase. (423 aa)
THA_10965,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (305 aa)
THA_1099Bifunctional aspartokinase/homoserine dehydrogen ase. (383 aa)
arcCCarbamate kinase; Belongs to the carbamate kinase family. (313 aa)
glpXFructose-1,6-bisphosphatase, class II. (339 aa)
THA_1150Glyoxylate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (317 aa)
THA_1204Pyk pyruvate kinase; Belongs to the pyruvate kinase family. (470 aa)
THA_125Fatty aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (445 aa)
glnA1Glutamine synthetase, type I. (439 aa)
pfkB1-phosphofructokinase; Belongs to the carbohydrate kinase PfkB family. (307 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (384 aa)
THA_1332Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase. (264 aa)
THA_1335HAD superfamily (subfamily IA) hydrolase. (225 aa)
mgsAMethylglyoxal synthase; Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. (128 aa)
pgiPgi glucose-6-phosphate isomerase; Belongs to the GPI family. (449 aa)
THA_1415methylmalonyl-CoAmutase, subunit alpha. (132 aa)
THA_1416glutaconyl-CoA decarboxylase subunit gamma. (135 aa)
THA_1417Hypothetical protein. (115 aa)
THA_1419methylmalonyl-CoA epimerase. (69 aa)
THA_1440acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (400 aa)
THA_1441Acetate CoA-transferase subunit beta. (214 aa)
THA_1442Acetate CoA-transferase subunit alpha. (216 aa)
THA_1446Glucose kinase. (310 aa)
THA_1470Phosphoenolpyruvate carboxykinase. (544 aa)
cysKCysteine synthase A. (285 aa)
THA_1477Serine acetyltransferase. (189 aa)
ldhL-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (303 aa)
THA_155methylmalonyl-CoA mutase, N- domain/subunit. (559 aa)
THA_156Chain P, L-Fuculose-1-Phosphate Aldolase; Similar to protein from Escherichia coli Mutant T26a. (212 aa)
rpiBRibose 5-phosphate isomerase B. (145 aa)
tpiATriose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (240 aa)
THA_1607Gap glyceraldehyde-3-phosphate dehydrogenase, type I; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (332 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (406 aa)
THA_1613Fba fructose-1,6-bisphosphate aldolase, class II. (312 aa)
thrCThreonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (403 aa)
THA_1683Glutamate synthase, beta subunit. (616 aa)
THA_170Asd aspartate-semialdehyde dehydrogenase; Belongs to the aspartate-semialdehyde dehydrogenase family. (322 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine. (237 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (293 aa)
apgMPhosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (402 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (217 aa)
THA_175Aspartokinase 2 (Aspartokinase II) (Aspartate kinase 2); Belongs to the aspartokinase family. (399 aa)
THA_176Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (386 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (319 aa)
talTransaldolase, putative; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (216 aa)
glnA2Glutamine synthetase, type I. (456 aa)
THA_1858Rpe ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (213 aa)
THA_1860Exopolyphosphatase family protein. (328 aa)
THA_188Succinyl-diaminopimelate desuccinylase. (407 aa)
THA_1902-oxoglutarate synthase subunit KorA. (386 aa)
THA_191OorD subunit of 2-oxoglutarate:acceptor oxidoreductase. (75 aa)
THA_192Oxaloacetate decarboxylase beta chain. (378 aa)
THA_1929Succinyl-diaminopimelate desuccinylase. (464 aa)
THA_1966-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. (335 aa)
THA_19772-oxoacid ferredoxin oxidoreductase, alpha subunit. (556 aa)
THA_1978Ferrodoxin oxidoreductase beta subunit. (265 aa)
folDBifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (271 aa)
THA_243Aldose 1-epimerase; Converts alpha-aldose to the beta-anomer. (342 aa)
THA_244L-allo-threonine aldolase. (343 aa)
THA_26Pyridoxal-5'-phosphate-dependent enzyme, beta subunit. (472 aa)
THA_302Putative hydroxypyruvate reductase. (407 aa)
porG2-oxoglutarate oxidoreductase, gamma subunit. (179 aa)
THA_3352-oxoglutarate oxidoreductase, beta subunit. (250 aa)
vorB2-oxoglutarate oxidoreductase, alpha subunit. (352 aa)
THA_337Conserved domain protein. (73 aa)
serAD-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (303 aa)
ppdKPyruvate, phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (881 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (316 aa)
THA_402Adenylylsulfate kinase. (159 aa)
enoEno phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (429 aa)
THA_425MaoC family protein. (136 aa)
THA_518Pyruvate oxidoreductase beta subunit. (325 aa)
THA_519Pyruvate synthase subunit PorA. (392 aa)
THA_520Pyruvate synthase subunit PorD. (110 aa)
THA_521Pyruvate/ketoisovalerate oxidoreductases common subunit gamma. (191 aa)
THA_53Transketolase. (620 aa)
lpdADihydrolipoyl dehydrogenase. (447 aa)
THA_550Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (427 aa)
fhsFhs formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. (551 aa)
THA_730acyl-CoA dehydrogenase, short-chain specific. (379 aa)
THA_762Probable 2-phosphosulfolactate phosphatase; Belongs to the ComB family. (226 aa)
THA_847Peptide amidase. (460 aa)
pfp6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (395 aa)
THA_956Propanediol utilization protein; Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate. (196 aa)
THA_96Keto/oxoacid ferredoxin oxidoreductase, gamma subunit, putative. (200 aa)
THA_972-oxoglutarate synthase subunit KorB. (274 aa)
Your Current Organism:
Thermosipho africanus
NCBI taxonomy Id: 484019
Other names: T. africanus TCF52B, Thermosipho africanus TCF52B, Thermosipho africanus str. TCF52B, Thermosipho africanus strain TCF52B
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