STRINGSTRING
trpB trpB glyA glyA metK metK THA_1094 THA_1094 THA_1099 THA_1099 argF argF THA_1204 THA_1204 glnA1 glnA1 pfkB pfkB lysA lysA THA_1326 THA_1326 THA_1465 THA_1465 cysK cysK THA_1477 THA_1477 rpiB rpiB tpiA tpiA THA_1607 THA_1607 THA_1613 THA_1613 thrC thrC THA_1683 THA_1683 patB patB THA_170 THA_170 dapF dapF dapA dapA apgM apgM dapB dapB dapH dapH THA_175 THA_175 THA_176 THA_176 pfkA pfkA tal tal glnA2 glnA2 THA_1858 THA_1858 THA_188 THA_188 THA_1929 THA_1929 THA_1948 THA_1948 THA_196 THA_196 THA_244 THA_244 THA_26 THA_26 prs prs eno eno sdaA1 sdaA1 sdaB sdaB THA_53 THA_53 aroK aroK THA_761 THA_761 THA_793 THA_793 THA_913 THA_913 pfp pfp THA_992 THA_992
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
trpBConserved hypothetical protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (420 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (424 aa)
metKMethionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (395 aa)
THA_10945-methyltetrahydrofolate S-homocysteine methyltransferase. (773 aa)
THA_1099Bifunctional aspartokinase/homoserine dehydrogen ase. (383 aa)
argFOrnithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (326 aa)
THA_1204Pyk pyruvate kinase; Belongs to the pyruvate kinase family. (470 aa)
glnA1Glutamine synthetase, type I. (439 aa)
pfkB1-phosphofructokinase; Belongs to the carbohydrate kinase PfkB family. (307 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (384 aa)
THA_1326Hydrolase, ama/HipO/hyuC family. (364 aa)
THA_1465Aspartate aminotransferase. (396 aa)
cysKCysteine synthase A. (285 aa)
THA_1477Serine acetyltransferase. (189 aa)
rpiBRibose 5-phosphate isomerase B. (145 aa)
tpiATriose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (240 aa)
THA_1607Gap glyceraldehyde-3-phosphate dehydrogenase, type I; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (332 aa)
THA_1613Fba fructose-1,6-bisphosphate aldolase, class II. (312 aa)
thrCThreonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (403 aa)
THA_1683Glutamate synthase, beta subunit. (616 aa)
patBAminotransferase, class II. (384 aa)
THA_170Asd aspartate-semialdehyde dehydrogenase; Belongs to the aspartate-semialdehyde dehydrogenase family. (322 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine. (237 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (293 aa)
apgMPhosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (402 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (217 aa)
dapHTetrahydrodipicolinate succinylase; Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate. (233 aa)
THA_175Aspartokinase 2 (Aspartokinase II) (Aspartate kinase 2); Belongs to the aspartokinase family. (399 aa)
THA_176Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (386 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (319 aa)
talTransaldolase, putative; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (216 aa)
glnA2Glutamine synthetase, type I. (456 aa)
THA_1858Rpe ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (213 aa)
THA_188Succinyl-diaminopimelate desuccinylase. (407 aa)
THA_1929Succinyl-diaminopimelate desuccinylase. (464 aa)
THA_1948Conserved hypothetical protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (420 aa)
THA_1966-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. (335 aa)
THA_244L-allo-threonine aldolase. (343 aa)
THA_26Pyridoxal-5'-phosphate-dependent enzyme, beta subunit. (472 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (316 aa)
enoEno phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (429 aa)
sdaA1A L-serine dehydratase, iron-sulfur-dependent, alpha subunit. (285 aa)
sdaBB L-serine dehydratase, iron-sulfur-dependent, beta subunit. (215 aa)
THA_53Transketolase. (620 aa)
aroKShikimate kinase. (159 aa)
THA_761Aspartate aminotransferase. (373 aa)
THA_793MTA/SAH nucleosidase. (217 aa)
THA_913Branched-chain amino acid aminotransferase 1. (246 aa)
pfp6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (395 aa)
THA_992Histidinol phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. (238 aa)
Your Current Organism:
Thermosipho africanus
NCBI taxonomy Id: 484019
Other names: T. africanus TCF52B, Thermosipho africanus TCF52B, Thermosipho africanus str. TCF52B, Thermosipho africanus strain TCF52B
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