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leuC leuC AJR22431.1 AJR22431.1 AJR22447.1 AJR22447.1 ispH ispH AJR22585.1 AJR22585.1 AJR22587.1 AJR22587.1 nadA nadA AJR22614.1 AJR22614.1 AJR26081.1 AJR26081.1 AJR26094.1 AJR26094.1 AJR22782.1 AJR22782.1 queE queE rlmN rlmN AJR22884.1 AJR22884.1 AJR22917.1 AJR22917.1 AJR26140.1 AJR26140.1 thiC thiC AJR22938.1 AJR22938.1 AJR22939.1 AJR22939.1 AJR22945.1 AJR22945.1 AJR22985.1 AJR22985.1 ispG ispG ilvD ilvD AJR23255.1 AJR23255.1 AJR23268.1 AJR23268.1 AJR23289.1 AJR23289.1 AJR23298.1 AJR23298.1 AJR23311.1 AJR23311.1 AJR26203.1 AJR26203.1 AJR23393.1 AJR23393.1 AJR23464.1 AJR23464.1 AJR23507.1 AJR23507.1 AJR23552.1 AJR23552.1 AJR23630.1 AJR23630.1 AJR23645.1 AJR23645.1 AJR26259.1 AJR26259.1 AJR23660.1 AJR23660.1 AJR23662.1 AJR23662.1 AJR23665.1 AJR23665.1 AJR23839.1 AJR23839.1 AJR23848.1 AJR23848.1 AJR23857.1 AJR23857.1 AJR23866.1 AJR23866.1 AJR23882.1 AJR23882.1 AJR23883.1 AJR23883.1 AJR23884.1 AJR23884.1 AJR23885.1 AJR23885.1 queG queG AJR24134.1 AJR24134.1 AJR24136.1 AJR24136.1 AJR26326.1 AJR26326.1 AJR24213.1 AJR24213.1 AJR24267.1 AJR24267.1 AJR24320.1 AJR24320.1 AJR24328.1 AJR24328.1 AJR24331.1 AJR24331.1 AJR24513.1 AJR24513.1 AJR24627.1 AJR24627.1 AJR24656.1 AJR24656.1 AJR24677.1 AJR24677.1 AJR24807.1 AJR24807.1 AJR24850.1 AJR24850.1 AJR24960.1 AJR24960.1 moaA moaA AJR25135.1 AJR25135.1 fbiC fbiC AJR25199.1 AJR25199.1 AJR25212.1 AJR25212.1 AJR25213.1 AJR25213.1 AJR25365.1 AJR25365.1 AJR25385.1 AJR25385.1 AJR25386.1 AJR25386.1 fbiC-2 fbiC-2 AJR25426.1 AJR25426.1 AJR25427.1 AJR25427.1 AJR25430.1 AJR25430.1 AJR25439.1 AJR25439.1 lipA lipA bioB bioB AJR25535.1 AJR25535.1 AJR25539.1 AJR25539.1 AJR26509.1 AJR26509.1 AJR25543.1 AJR25543.1 purF purF AJR25613.1 AJR25613.1 nth nth AJR25650.1 AJR25650.1 miaB miaB edd edd AJR25715.1 AJR25715.1 AJR25745.1 AJR25745.1 nuoI nuoI AJR25781.1 AJR25781.1 AJR26532.1 AJR26532.1 AJR25782.1 AJR25782.1 nuoB nuoB AJR25827.1 AJR25827.1 rimO rimO AJR25957.1 AJR25957.1 AJR26018.1 AJR26018.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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leuCIsopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (484 aa)
AJR22431.1Hemerythrin; Derived by automated computational analysis using gene prediction method: Protein Homology. (170 aa)
AJR22447.1Heme biosynthesis protein HemY; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the HesB/IscA family. (108 aa)
ispH4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (315 aa)
AJR22585.1Coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (391 aa)
AJR22587.1Glutaredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutaredoxin family. Monothiol subfamily. (110 aa)
nadAQuinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (328 aa)
AJR22614.1Nitrate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily. (873 aa)
AJR26081.1Nitrite reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (111 aa)
AJR26094.1Dihydroxy-acid dehydratase; Catalyzes the formation of 3-methyl-2-oxobutanoate from 2,3,-dihydroxy-3-methylbutanoate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (573 aa)
AJR22782.1Ubiquinol-cytochrome c reductase iron-sulfur subunit; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. (193 aa)
queE7-cyano-7-deazaguanine reductase; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (215 aa)
rlmNRNA methyltransferase RlmN; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. (419 aa)
AJR22884.1Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (506 aa)
AJR22917.1Molybdopterin dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (316 aa)
AJR26140.1Ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (216 aa)
thiCPhosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (619 aa)
AJR22938.1HesB/YadR/YfhF; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the HesB/IscA family. (120 aa)
AJR22939.1FeS assembly SUF system protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (149 aa)
AJR22945.1Cysteine desulfurase; Derived by automated computational analysis using gene prediction method: Protein Homology. (494 aa)
AJR22985.1Adenine glycosylase; Adenine glycosylase active on G-A mispairs. (356 aa)
ispG4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (386 aa)
ilvDDihydroxy-acid dehydratase; Catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (617 aa)
AJR23255.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (424 aa)
AJR23268.1Ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (105 aa)
AJR23289.1(2Fe-2S)-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (447 aa)
AJR23298.1(2Fe-2S)-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (446 aa)
AJR23311.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (414 aa)
AJR26203.1Reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (106 aa)
AJR23393.1Molybdopterin dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (328 aa)
AJR23464.1Cobalamin biosynthesis protein CobG; Derived by automated computational analysis using gene prediction method: Protein Homology. (354 aa)
AJR23507.1Formate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (758 aa)
AJR23552.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (163 aa)
AJR23630.1Nitrogen fixation protein FixG; Derived by automated computational analysis using gene prediction method: Protein Homology. (476 aa)
AJR23645.1Dihydroxy-acid dehydratase; Catalyzes the formation of 3-methyl-2-oxobutanoate from 2,3,-dihydroxy-3-methylbutanoate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (596 aa)
AJR26259.1Coproporphyrinogen III oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (435 aa)
AJR23660.1Rieske (2Fe-2S) protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (411 aa)
AJR23662.1(2Fe-2S)-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (397 aa)
AJR23665.1Ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (100 aa)
AJR23839.1Rieske (2Fe-2S) protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (357 aa)
AJR23848.1Ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (115 aa)
AJR23857.1Phenol hydroxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (352 aa)
AJR23866.14Fe-4S ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (130 aa)
AJR23882.12Fe-2S ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (121 aa)
AJR23883.1ATP synthase subunit E; Derived by automated computational analysis using gene prediction method: Protein Homology. (155 aa)
AJR23884.1Formate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (526 aa)
AJR23885.1Formate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (948 aa)
queGEpoxyqueuosine reductase; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (340 aa)
AJR24134.1Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1512 aa)
AJR24136.1Dihydropyrimidine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (483 aa)
AJR26326.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (163 aa)
AJR24213.1Dihydroxy-acid dehydratase; Catalyzes the formation of 3-methyl-2-oxobutanoate from 2,3,-dihydroxy-3-methylbutanoate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (600 aa)
AJR24267.1Isoquinoline 1-oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (178 aa)
AJR24320.1NagC family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (559 aa)
AJR24328.1DNA polymerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (465 aa)
AJR24331.1Biotin synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (415 aa)
AJR24513.1Ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (105 aa)
AJR24627.1Chromosome partitioning protein ParA; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (321 aa)
AJR24656.1Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (112 aa)
AJR24677.12Fe-2S ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (385 aa)
AJR24807.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (262 aa)
AJR24850.1(2Fe-2S)-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (56 aa)
AJR24960.1Sulfite reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (543 aa)
moaAMolybdenum cofactor biosynthesis protein MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (336 aa)
AJR25135.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (206 aa)
fbiCFO synthase; 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase; catalyzes radical-mediated transfer of hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO); functions in F420 biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (802 aa)
AJR25199.1uracil-DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (218 aa)
AJR25212.1Aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (371 aa)
AJR25213.12Fe-2S ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (111 aa)
AJR25365.1(2Fe-2S)-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (404 aa)
AJR25385.1(2Fe-2S)-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (461 aa)
AJR25386.1Ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (68 aa)
fbiC-2FO synthase; 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase; catalyzes radical-mediated transfer of hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO); functions in F420 biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (779 aa)
AJR25426.1Oxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (357 aa)
AJR25427.1(2Fe-2S)-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (312 aa)
AJR25430.1Ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (105 aa)
AJR25439.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (422 aa)
lipARadical SAM protein; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (327 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (332 aa)
AJR25535.1RNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (401 aa)
AJR25539.1Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (550 aa)
AJR26509.1uracil-DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (234 aa)
AJR25543.1DNA repair photolyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (355 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (486 aa)
AJR25613.1Ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (63 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (216 aa)
AJR25650.1Iron transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (190 aa)
miaB(dimethylallyl)adenosine tRNA methylthiotransferase; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (449 aa)
eddPhosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (613 aa)
AJR25715.1Nitrogen-fixing protein NifU; Derived by automated computational analysis using gene prediction method: Protein Homology. (140 aa)
AJR25745.1Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (889 aa)
nuoINADH dehydrogenase; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (161 aa)
AJR25781.1NADH dehydrogenase; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Belongs to the complex I 75 kDa subunit family. (668 aa)
AJR26532.1NADH dehydrogenase; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family. (438 aa)
AJR25782.1NADH dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (222 aa)
nuoBNADH-quinone oxidoreductase subunit B; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (184 aa)
AJR25827.1Serine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. (464 aa)
rimORibosomal protein S12 methylthiotransferase; Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12; Belongs to the methylthiotransferase family. RimO subfamily. (455 aa)
AJR25957.1Coenzyme F420 hydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (457 aa)
AJR26018.12-methylthioadenine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (420 aa)
Your Current Organism:
Sphingobium sp. YBL2
NCBI taxonomy Id: 484429
Other names: S. sp. YBL2
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