STRINGSTRING
polA polA Phep_0020 Phep_0020 Phep_0021 Phep_0021 Phep_0075 Phep_0075 Phep_0121 Phep_0121 dnaG dnaG rpoA rpoA Phep_0634 Phep_0634 dnaX dnaX rpoB rpoB rpoC rpoC Phep_0854 Phep_0854 Phep_0866 Phep_0866 Phep_1144 Phep_1144 Phep_1251 Phep_1251 dinB dinB Phep_1371 Phep_1371 coaD coaD Phep_1496 Phep_1496 Phep_1532 Phep_1532 Phep_1567 Phep_1567 Phep_1632 Phep_1632 Phep_1702 Phep_1702 pnp pnp Phep_2062 Phep_2062 Phep_2398 Phep_2398 Phep_2399 Phep_2399 ispD ispD kdsB kdsB dinB-2 dinB-2 Phep_3075 Phep_3075 Phep_3085 Phep_3085 Phep_3087 Phep_3087 Phep_3088 Phep_3088 Phep_3235 Phep_3235 Phep_3314 Phep_3314 Phep_3549 Phep_3549 dacA dacA Phep_3831 Phep_3831 Phep_3941 Phep_3941 Phep_4022 Phep_4022 Phep_4196 Phep_4196 nadD nadD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (939 aa)
Phep_0020PFAM: Cytidylyltransferase family; Belongs to the CDS family. (269 aa)
Phep_0021Conserved hypothetical protein. (71 aa)
Phep_0075DNA polymerase III gamma/tau subunit. (382 aa)
Phep_0121ATPase/kinase involved in NAD metabolism-like protein; TIGRFAM: nicotinamide-nucleotide adenylyltransferase, NadR type. (176 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (660 aa)
rpoADNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (330 aa)
Phep_0634Conserved hypothetical protein. (300 aa)
dnaXDNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (602 aa)
rpoBDNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1267 aa)
rpoCDNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1428 aa)
Phep_0854Polynucleotide adenylyltransferase region; PFAM: HD domain; Poly A polymerase head domain; TIGRFAM: uncharacterized domain HDIG; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (468 aa)
Phep_0866PFAM: Exonuclease; Bacterial DNA polymerase III alpha subunit; OB-fold nucleic acid binding domain; PHP domain; TIGRFAM: DNA-directed DNA polymerase III (polc). (1476 aa)
Phep_1144Hypothetical protein. (109 aa)
Phep_1251PFAM: DNA polymerase III, delta subunit; TIGRFAM: DNA polymerase III, delta subunit. (341 aa)
dinBDNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (385 aa)
Phep_1371PFAM: Bacterial DNA polymerase III alpha subunit; PHP domain; TIGRFAM: DNA-directed DNA polymerase III (polc). (979 aa)
coaDPantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (153 aa)
Phep_1496PFAM: Streptomycin adenylyltransferase. (297 aa)
Phep_1532RNA polymerase sigma-54 factor, RpoN; PFAM: Sigma-54 factor, core binding domain; Sigma-54 factor, Activator interacting domain (AID); Sigma-54, DNA binding domain; TIGRFAM: RNA polymerase sigma-54 factor. (490 aa)
Phep_1567Hypothetical protein. (391 aa)
Phep_1632Conserved hypothetical protein. (436 aa)
Phep_1702DNA ligase D; PFAM: Eukaryotic and archaeal DNA primase small subunit; ATP dependent DNA ligase domain; ATP dependent DNA ligase C terminal region; TIGRFAM: DNA polymerase LigD, polymerase domain; DNA ligase D, 3'-phosphoesterase domain; DNA ligase D; DNA polymerase LigD, ligase domain. (877 aa)
pnpPolyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (716 aa)
Phep_2062PFAM: Nucleotidyl transferase; TIGRFAM: mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase. (363 aa)
Phep_2398PFAM: Bacterial DNA polymerase III alpha subunit; PHP domain; OB-fold nucleic acid binding domain; TIGRFAM: glutamate--cysteine ligase/gamma-glutamylcysteine synthetase, Streptococcus agalactiae type; DNA-directed DNA polymerase III (polc); Belongs to the DNA polymerase type-C family. DnaE2 subfamily. (1045 aa)
Phep_2399Cytosolic protein. (500 aa)
ispD2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (225 aa)
kdsB3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (242 aa)
dinB-2DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (358 aa)
Phep_3075PFAM: PHP domain. (558 aa)
Phep_3085PFAM: Nucleotidyl transferase; TIGRFAM: glucose-1-phosphate adenylyltransferase. (425 aa)
Phep_3087Sulfate adenylyltransferase, large subunit; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (416 aa)
Phep_3088Sulfate adenylyltransferase, small subunit; PFAM: Phosphoadenosine phosphosulfate reductase family; TIGRFAM: sulfate adenylyltransferase, small subunit. (301 aa)
Phep_3235DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (374 aa)
Phep_3314PFAM: RES domain. (150 aa)
Phep_3549Riboflavin biosynthesis protein RibF; PFAM: Riboflavin kinase; FAD synthetase; TIGRFAM: riboflavin kinase/FMN adenylyltransferase; cytidyltransferase-related domain; Belongs to the ribF family. (311 aa)
dacAProtein of unknown function DUF147; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (263 aa)
Phep_3831Hypothetical protein. (2396 aa)
Phep_3941PFAM: Cytidylyltransferase. (237 aa)
Phep_4022Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (286 aa)
Phep_4196YicC domain protein; PFAM: Domain of unknown function (DUF1732); YicC-like family, N-terminal region; TIGRFAM: conserved hypothetical protein TIGR00255. (287 aa)
nadDNicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (190 aa)
Your Current Organism:
Pedobacter heparinus
NCBI taxonomy Id: 485917
Other names: P. heparinus DSM 2366, Pedobacter heparinus DSM 2366, Pedobacter heparinus IFO 12017, Pedobacter heparinus LMG 10339, Pedobacter heparinus str. DSM 2366, Pedobacter heparinus strain DSM 2366
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