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pyrH pyrH Phep_0124 Phep_0124 Phep_0227 Phep_0227 ndk ndk Phep_0646 Phep_0646 Phep_0690 Phep_0690 Phep_0691 Phep_0691 carA carA tdk tdk Phep_0979 Phep_0979 Phep_0992 Phep_0992 Phep_1041 Phep_1041 pyrB pyrB Phep_1174 Phep_1174 cmk cmk pyrD pyrD thyA thyA pyrE pyrE Phep_2180 Phep_2180 Phep_2185 Phep_2185 Phep_2581 Phep_2581 pyrG pyrG Phep_2916 Phep_2916 Phep_3069 Phep_3069 Phep_3185 Phep_3185 Phep_3229 Phep_3229 surE surE surE-2 surE-2 Phep_3621 Phep_3621 dut dut Phep_3862 Phep_3862 Phep_4038 Phep_4038
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (235 aa)
Phep_0124Carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain, N-terminal domain; Carbamoyl-phosphate synthase L chain, ATP binding domain; Carbamoyl-phosphate synthetase large chain, oligomerisation domain; ATP-grasp domain; TIGRFAM: carbamoyl-phosphate synthase, large subunit. (938 aa)
Phep_0227TIGRFAM: deoxycytidine triphosphate deaminase. (195 aa)
ndkNucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (139 aa)
Phep_0646Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (271 aa)
Phep_0690Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (324 aa)
Phep_0691Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (792 aa)
carAPFAM: Glutamine amidotransferase class-I; Carbamoyl-phosphate synthase small chain, CPSase domain; TIGRFAM: carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (370 aa)
tdkPFAM: Thymidine kinase. (193 aa)
Phep_0979Short-chain dehydrogenase/reductase SDR; PFAM: short chain dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (254 aa)
Phep_0992PFAM: Cytidine and deoxycytidylate deaminase zinc-binding region. (151 aa)
Phep_1041Conserved hypothetical protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. (100 aa)
pyrBPFAM: Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; TIGRFAM: aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (310 aa)
Phep_1174Uracil phosphoribosyltransferase; PFAM: Phosphoribosyl transferase domain. (182 aa)
cmkPFAM: Cytidylate kinase; Shikimate kinase; TIGRFAM: cytidylate kinase. (225 aa)
pyrDDihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (344 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (221 aa)
Phep_2180PFAM: Phosphorylase superfamily. (288 aa)
Phep_2185Metallophosphoesterase; PFAM: Calcineurin-like phosphoesterase; TIGRFAM: Tat (twin-arginine translocation) pathway signal sequence; Belongs to the 5'-nucleotidase family. (315 aa)
Phep_2581PFAM: Deoxynucleoside kinase. (204 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (538 aa)
Phep_2916PFAM: Phosphoribulokinase / Uridine kinase family. (213 aa)
Phep_3069PFAM: Orotidine 5'-phosphate decarboxylase / HUMPS family; TIGRFAM: orotidine 5'-phosphate decarboxylase, subfamily 2. (276 aa)
Phep_3185PFAM: Amidohydrolase family; TIGRFAM: dihydroorotase, multifunctional complex type. (419 aa)
Phep_3229PFAM: Amidohydrolase family; TIGRFAM: dihydroorotase, multifunctional complex type. (444 aa)
surEStationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (243 aa)
surE-2Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (287 aa)
Phep_3621Bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase. (169 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (143 aa)
Phep_3862PFAM: 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C). (184 aa)
Phep_4038PFAM: Phosphoribosyl transferase domain; TIGRFAM: uracil phosphoribosyltransferase. (214 aa)
Your Current Organism:
Pedobacter heparinus
NCBI taxonomy Id: 485917
Other names: P. heparinus DSM 2366, Pedobacter heparinus DSM 2366, Pedobacter heparinus IFO 12017, Pedobacter heparinus LMG 10339, Pedobacter heparinus str. DSM 2366, Pedobacter heparinus strain DSM 2366
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