(23 nodes) Mixed, incl. Fibrinogen complex, and Common Pathway of Fibrin Clot Formation network (Poecilia formosa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	fgb	Fibrinogen beta chain. (492 aa)
	ENSPFOP00000000852	Fibrinogen alpha chain. (580 aa)
	LOC103156615	SERPIN domain-containing protein; Belongs to the serpin family. (428 aa)
	LOC103132867	Si:ch1073-416d2.3; Belongs to the serpin family. (405 aa)
	ENSPFOP00000002923	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (792 aa)
	ENSPFOP00000003818	SERPIN domain-containing protein; Belongs to the serpin family. (471 aa)
	LOC103130323	Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. (430 aa)
	serpinc1	Serpin peptidase inhibitor, clade C (antithrombin), member 1; Belongs to the serpin family. (449 aa)
	f2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (617 aa)
	ENSPFOP00000006274	Alpha-2-HS-glycoprotein 2. (352 aa)
	LOC103130102	Coagulation factor VIIi. (447 aa)
	LOC103139979	Uncharacterized protein. (338 aa)
	ENSPFOP00000007936	Plasminogen activator, urokinase a; Belongs to the peptidase S1 family. (373 aa)
	LOC103132867-2	Protein Z-dependent protease inhibitor-like. (405 aa)
	fgg	Fibrinogen gamma chain. (432 aa)
	ENSPFOP00000012768	Coagulation factor IXa. (557 aa)
	APOH	Apolipoprotein H. (363 aa)
	serpind1	Serpin peptidase inhibitor, clade D (heparin cofactor), member 1; Belongs to the serpin family. (505 aa)
	LOC103147815	Alpha-1-microglobulin/bikunin precursor. (368 aa)
	LOC103130090	Coagulation factor X. (512 aa)
	ENSPFOP00000023943	Fib_alpha domain-containing protein. (216 aa)
	LOC107832858	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (225 aa)
	ENSPFOP00000031233	Serpin family B member 8; Belongs to the serpin family. (388 aa)

Your Current Organism:

Poecilia formosa

NCBI taxonomy Id: 48698
Other names: Amazon molly, Limia formosa, Mollienesia formosa, P. formosa

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APOH	ENSPFOP00000000852	ENSPFOP00000014016	ENSPFOP00000000852	Apolipoprotein H.	Fibrinogen alpha chain.	0.697
APOH	ENSPFOP00000002923	ENSPFOP00000014016	ENSPFOP00000002923	Apolipoprotein H.	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	0.849
APOH	ENSPFOP00000003818	ENSPFOP00000014016	ENSPFOP00000003818	Apolipoprotein H.	SERPIN domain-containing protein; Belongs to the serpin family.	0.581
APOH	ENSPFOP00000006274	ENSPFOP00000014016	ENSPFOP00000006274	Apolipoprotein H.	Alpha-2-HS-glycoprotein 2.	0.876
APOH	ENSPFOP00000023943	ENSPFOP00000014016	ENSPFOP00000023943	Apolipoprotein H.	Fib_alpha domain-containing protein.	0.697
APOH	LOC103130323	ENSPFOP00000014016	ENSPFOP00000004089	Apolipoprotein H.	Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.	0.567
APOH	LOC103132867	ENSPFOP00000014016	ENSPFOP00000001478	Apolipoprotein H.	Si:ch1073-416d2.3; Belongs to the serpin family.	0.481
APOH	LOC103132867-2	ENSPFOP00000014016	ENSPFOP00000011179	Apolipoprotein H.	Protein Z-dependent protease inhibitor-like.	0.481
APOH	LOC103147815	ENSPFOP00000014016	ENSPFOP00000019812	Apolipoprotein H.	Alpha-1-microglobulin/bikunin precursor.	0.773
APOH	LOC103156615	ENSPFOP00000014016	ENSPFOP00000000877	Apolipoprotein H.	SERPIN domain-containing protein; Belongs to the serpin family.	0.581
APOH	LOC107832858	ENSPFOP00000014016	ENSPFOP00000030528	Apolipoprotein H.	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family.	0.773
APOH	f2	ENSPFOP00000014016	ENSPFOP00000005858	Apolipoprotein H.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.880
APOH	fgb	ENSPFOP00000014016	ENSPFOP00000000813	Apolipoprotein H.	Fibrinogen beta chain.	0.663
APOH	fgg	ENSPFOP00000014016	ENSPFOP00000012670	Apolipoprotein H.	Fibrinogen gamma chain.	0.836
APOH	serpinc1	ENSPFOP00000014016	ENSPFOP00000005544	Apolipoprotein H.	Serpin peptidase inhibitor, clade C (antithrombin), member 1; Belongs to the serpin family.	0.858
APOH	serpind1	ENSPFOP00000014016	ENSPFOP00000014404	Apolipoprotein H.	Serpin peptidase inhibitor, clade D (heparin cofactor), member 1; Belongs to the serpin family.	0.644
ENSPFOP00000000852	APOH	ENSPFOP00000000852	ENSPFOP00000014016	Fibrinogen alpha chain.	Apolipoprotein H.	0.697
ENSPFOP00000000852	ENSPFOP00000002923	ENSPFOP00000000852	ENSPFOP00000002923	Fibrinogen alpha chain.	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	0.957
ENSPFOP00000000852	ENSPFOP00000003818	ENSPFOP00000000852	ENSPFOP00000003818	Fibrinogen alpha chain.	SERPIN domain-containing protein; Belongs to the serpin family.	0.713
ENSPFOP00000000852	ENSPFOP00000006274	ENSPFOP00000000852	ENSPFOP00000006274	Fibrinogen alpha chain.	Alpha-2-HS-glycoprotein 2.	0.924