(10 nodes) Mixed, incl. Fibrinogen alpha/beta chain family, and Hemostasis network (Poecilia formosa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	fgb	Fibrinogen beta chain. (492 aa)
	ENSPFOP00000000852	Fibrinogen alpha chain. (580 aa)
	ENSPFOP00000002923	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (792 aa)
	serpinc1	Serpin peptidase inhibitor, clade C (antithrombin), member 1; Belongs to the serpin family. (449 aa)
	f2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (617 aa)
	ENSPFOP00000006274	Alpha-2-HS-glycoprotein 2. (352 aa)
	fgg	Fibrinogen gamma chain. (432 aa)
	APOH	Apolipoprotein H. (363 aa)
	serpind1	Serpin peptidase inhibitor, clade D (heparin cofactor), member 1; Belongs to the serpin family. (505 aa)
	LOC103147815	Alpha-1-microglobulin/bikunin precursor. (368 aa)

Your Current Organism:

Poecilia formosa

NCBI taxonomy Id: 48698
Other names: Amazon molly, Limia formosa, Mollienesia formosa, P. formosa

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APOH	ENSPFOP00000000852	ENSPFOP00000014016	ENSPFOP00000000852	Apolipoprotein H.	Fibrinogen alpha chain.	0.697
APOH	ENSPFOP00000002923	ENSPFOP00000014016	ENSPFOP00000002923	Apolipoprotein H.	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	0.849
APOH	ENSPFOP00000006274	ENSPFOP00000014016	ENSPFOP00000006274	Apolipoprotein H.	Alpha-2-HS-glycoprotein 2.	0.876
APOH	LOC103147815	ENSPFOP00000014016	ENSPFOP00000019812	Apolipoprotein H.	Alpha-1-microglobulin/bikunin precursor.	0.773
APOH	f2	ENSPFOP00000014016	ENSPFOP00000005858	Apolipoprotein H.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.880
APOH	fgb	ENSPFOP00000014016	ENSPFOP00000000813	Apolipoprotein H.	Fibrinogen beta chain.	0.663
APOH	fgg	ENSPFOP00000014016	ENSPFOP00000012670	Apolipoprotein H.	Fibrinogen gamma chain.	0.836
APOH	serpinc1	ENSPFOP00000014016	ENSPFOP00000005544	Apolipoprotein H.	Serpin peptidase inhibitor, clade C (antithrombin), member 1; Belongs to the serpin family.	0.858
APOH	serpind1	ENSPFOP00000014016	ENSPFOP00000014404	Apolipoprotein H.	Serpin peptidase inhibitor, clade D (heparin cofactor), member 1; Belongs to the serpin family.	0.644
ENSPFOP00000000852	APOH	ENSPFOP00000000852	ENSPFOP00000014016	Fibrinogen alpha chain.	Apolipoprotein H.	0.697
ENSPFOP00000000852	ENSPFOP00000002923	ENSPFOP00000000852	ENSPFOP00000002923	Fibrinogen alpha chain.	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	0.957
ENSPFOP00000000852	ENSPFOP00000006274	ENSPFOP00000000852	ENSPFOP00000006274	Fibrinogen alpha chain.	Alpha-2-HS-glycoprotein 2.	0.924
ENSPFOP00000000852	LOC103147815	ENSPFOP00000000852	ENSPFOP00000019812	Fibrinogen alpha chain.	Alpha-1-microglobulin/bikunin precursor.	0.798
ENSPFOP00000000852	f2	ENSPFOP00000000852	ENSPFOP00000005858	Fibrinogen alpha chain.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.995
ENSPFOP00000000852	fgb	ENSPFOP00000000852	ENSPFOP00000000813	Fibrinogen alpha chain.	Fibrinogen beta chain.	0.998
ENSPFOP00000000852	fgg	ENSPFOP00000000852	ENSPFOP00000012670	Fibrinogen alpha chain.	Fibrinogen gamma chain.	0.998
ENSPFOP00000000852	serpinc1	ENSPFOP00000000852	ENSPFOP00000005544	Fibrinogen alpha chain.	Serpin peptidase inhibitor, clade C (antithrombin), member 1; Belongs to the serpin family.	0.949
ENSPFOP00000000852	serpind1	ENSPFOP00000000852	ENSPFOP00000014404	Fibrinogen alpha chain.	Serpin peptidase inhibitor, clade D (heparin cofactor), member 1; Belongs to the serpin family.	0.843
ENSPFOP00000002923	APOH	ENSPFOP00000002923	ENSPFOP00000014016	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	Apolipoprotein H.	0.849
ENSPFOP00000002923	ENSPFOP00000000852	ENSPFOP00000002923	ENSPFOP00000000852	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	Fibrinogen alpha chain.	0.957