(48 nodes) Mixed, incl. Hormone ligand-binding receptors, and Regulation of FZD by ubiquitination network (Poecilia formosa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	rnf175	Ring finger protein 175. (313 aa)
	LOC103144506	Cytoplasmic polyadenylation element binding protein 4a. (741 aa)
	pin4	Peptidyl-prolyl cis-trans isomerase. (154 aa)
	ENSPFOP00000000972	Luteinizing hormone, beta polypeptide. (147 aa)
	rnf44	Ring finger protein 44. (440 aa)
	ENSPFOP00000001367	Leucine-rich repeat containing G protein-coupled receptor 4. (977 aa)
	LOC103147694	Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (782 aa)
	gphb5	Si:dkey-23i12.9. (129 aa)
	gpha2	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (132 aa)
	LOC103141530	R-spondin 1. (179 aa)
	ENSPFOP00000002513	NMDA receptor synaptonuclear signaling and neuronal migration factor b. (576 aa)
	LOC103139527	V-set and transmembrane domain containing 2 like. (209 aa)
	LGR6	Leucine rich repeat containing G protein-coupled receptor 6. (931 aa)
	rnf111	Ring finger protein 111. (1021 aa)
	LOC103139316	Leucine-rich repeat-containing G-protein coupled receptor 4. (977 aa)
	TSHB	Thyroid stimulating hormone subunit beta. (132 aa)
	TSHR	Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (708 aa)
	rnf122	Ring finger protein 122. (155 aa)
	LOC103131544	Zgc:175214. (155 aa)
	lrtm1	Leucine rich repeats and transmembrane domains 1. (377 aa)
	ENSPFOP00000007881	Proprotein convertase subtilisin/kexin type 7; Belongs to the peptidase S8 family. (675 aa)
	ENSPFOP00000008778	Si:ch211-81a5.1. (327 aa)
	LOC103145124	Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (698 aa)
	LOC103143892	STE20-like kinase b. (1001 aa)
	ENSPFOP00000010261	RING-type domain-containing protein. (582 aa)
	RSPO3	R-spondin 3. (260 aa)
	VSTM2L	V-set and transmembrane domain containing 2 like. (255 aa)
	pcsk1	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (766 aa)
	LGR5	Leucine rich repeat containing G protein-coupled receptor 5. (927 aa)
	LOC103154929	Si:dkey-51a16.9. (156 aa)
	LOC103134583	Thyroid stimulating hormone subunit beta a. (146 aa)
	rnf115	Ring finger protein 115. (314 aa)
	ENSPFOP00000014193	Proprotein convertase subtilisin/kexin type 5a. (1884 aa)
	cga	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (126 aa)
	rnf165	Ring finger protein 165a. (346 aa)
	ENSPFOP00000014566	Zinc and ring finger 3. (746 aa)
	LHCGR	Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (696 aa)
	slk	STE20-like kinase a. (1154 aa)
	LOC103151628	Ring finger protein 150b. (445 aa)
	RNF43	Ring finger protein 43. (705 aa)
	rspo2	R-spondin 2. (274 aa)
	LOC103133065	RING-type domain-containing protein. (325 aa)
	ENSPFOP00000023625	Peptidase_S8 domain-containing protein. (131 aa)
	ENSPFOP00000024859	RING-type domain-containing protein. (401 aa)
	ENSPFOP00000025096	R-spondin 4. (255 aa)
	ENSPFOP00000027968	Luteinizing hormone/choriogonadotropin receptor. (613 aa)
	ENSPFOP00000028423	Uncharacterized protein. (79 aa)
	LOC103136649	R-spondin 3. (290 aa)

Your Current Organism:

Poecilia formosa

NCBI taxonomy Id: 48698
Other names: Amazon molly, Limia formosa, Mollienesia formosa, P. formosa

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPFOP00000000972	ENSPFOP00000001367	ENSPFOP00000000972	ENSPFOP00000001367	Luteinizing hormone, beta polypeptide.	Leucine-rich repeat containing G protein-coupled receptor 4.	0.685
ENSPFOP00000000972	ENSPFOP00000027968	ENSPFOP00000000972	ENSPFOP00000027968	Luteinizing hormone, beta polypeptide.	Luteinizing hormone/choriogonadotropin receptor.	0.956
ENSPFOP00000000972	LGR5	ENSPFOP00000000972	ENSPFOP00000011716	Luteinizing hormone, beta polypeptide.	Leucine rich repeat containing G protein-coupled receptor 5.	0.685
ENSPFOP00000000972	LGR6	ENSPFOP00000000972	ENSPFOP00000003930	Luteinizing hormone, beta polypeptide.	Leucine rich repeat containing G protein-coupled receptor 6.	0.770
ENSPFOP00000000972	LHCGR	ENSPFOP00000000972	ENSPFOP00000015184	Luteinizing hormone, beta polypeptide.	Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.	0.961
ENSPFOP00000000972	LOC103139316	ENSPFOP00000000972	ENSPFOP00000004267	Luteinizing hormone, beta polypeptide.	Leucine-rich repeat-containing G-protein coupled receptor 4.	0.685
ENSPFOP00000000972	LOC103145124	ENSPFOP00000000972	ENSPFOP00000009281	Luteinizing hormone, beta polypeptide.	Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.	0.800
ENSPFOP00000000972	LOC103147694	ENSPFOP00000000972	ENSPFOP00000001548	Luteinizing hormone, beta polypeptide.	Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.	0.784
ENSPFOP00000000972	TSHR	ENSPFOP00000000972	ENSPFOP00000004982	Luteinizing hormone, beta polypeptide.	Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.	0.784
ENSPFOP00000000972	cga	ENSPFOP00000000972	ENSPFOP00000014232	Luteinizing hormone, beta polypeptide.	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family.	0.989
ENSPFOP00000001367	ENSPFOP00000000972	ENSPFOP00000001367	ENSPFOP00000000972	Leucine-rich repeat containing G protein-coupled receptor 4.	Luteinizing hormone, beta polypeptide.	0.685
ENSPFOP00000001367	ENSPFOP00000007881	ENSPFOP00000001367	ENSPFOP00000007881	Leucine-rich repeat containing G protein-coupled receptor 4.	Proprotein convertase subtilisin/kexin type 7; Belongs to the peptidase S8 family.	0.735
ENSPFOP00000001367	ENSPFOP00000008778	ENSPFOP00000001367	ENSPFOP00000008778	Leucine-rich repeat containing G protein-coupled receptor 4.	Si:ch211-81a5.1.	0.675
ENSPFOP00000001367	ENSPFOP00000010261	ENSPFOP00000001367	ENSPFOP00000010261	Leucine-rich repeat containing G protein-coupled receptor 4.	RING-type domain-containing protein.	0.606
ENSPFOP00000001367	ENSPFOP00000014193	ENSPFOP00000001367	ENSPFOP00000014193	Leucine-rich repeat containing G protein-coupled receptor 4.	Proprotein convertase subtilisin/kexin type 5a.	0.735
ENSPFOP00000001367	ENSPFOP00000014566	ENSPFOP00000001367	ENSPFOP00000014566	Leucine-rich repeat containing G protein-coupled receptor 4.	Zinc and ring finger 3.	0.914
ENSPFOP00000001367	ENSPFOP00000023625	ENSPFOP00000001367	ENSPFOP00000023625	Leucine-rich repeat containing G protein-coupled receptor 4.	Peptidase_S8 domain-containing protein.	0.735
ENSPFOP00000001367	ENSPFOP00000024859	ENSPFOP00000001367	ENSPFOP00000024859	Leucine-rich repeat containing G protein-coupled receptor 4.	RING-type domain-containing protein.	0.606
ENSPFOP00000001367	ENSPFOP00000025096	ENSPFOP00000001367	ENSPFOP00000025096	Leucine-rich repeat containing G protein-coupled receptor 4.	R-spondin 4.	0.939
ENSPFOP00000001367	ENSPFOP00000027968	ENSPFOP00000001367	ENSPFOP00000027968	Leucine-rich repeat containing G protein-coupled receptor 4.	Luteinizing hormone/choriogonadotropin receptor.	0.519