(19 nodes) Mixed, incl. CORVET complex, and Mon1-Ccz1 complex network (Poecilia formosa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103152494	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (447 aa)
	LOC103132063	GRIP1 associated protein 1. (527 aa)
	ENSPFOP00000005771	VPS39 subunit of HOPS complex. (849 aa)
	ENSPFOP00000006527	Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family. (835 aa)
	mon1a	MON1 secretory trafficking family member A. (521 aa)
	vps33b	VPS33B late endosome and lysosome associated; Belongs to the STXBP/unc-18/SEC1 family. (613 aa)
	tgfbrap1	Transforming growth factor, beta receptor associated protein 1. (874 aa)
	vps18	VPS18 core subunit of CORVET and HOPS complexes. (982 aa)
	armc5	Armadillo repeat containing 5. (1132 aa)
	ccz1	CCZ1 homolog, vacuolar protein trafficking and biogenesis associated. (480 aa)
	vps41	Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family. (854 aa)
	fam189b	Si:dkey-7f3.9. (731 aa)
	vps33a	VPS33A core subunit of CORVET and HOPS complexes; Belongs to the STXBP/unc-18/SEC1 family. (600 aa)
	vps11	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (928 aa)
	LOC103136815	MON1 secretory trafficking family member Bb. (609 aa)
	vps8	VPS8 subunit of CORVET complex. (1345 aa)
	vipas39	VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog. (490 aa)
	rmc1	Regulator of MON1-CCZ1. (655 aa)
	ENSPFOP00000025548	Uncharacterized protein. (318 aa)

Your Current Organism:

Poecilia formosa

NCBI taxonomy Id: 48698
Other names: Amazon molly, Limia formosa, Mollienesia formosa, P. formosa

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPFOP00000005771	ENSPFOP00000006527	ENSPFOP00000005771	ENSPFOP00000006527	VPS39 subunit of HOPS complex.	Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family.	0.999
ENSPFOP00000005771	ENSPFOP00000025548	ENSPFOP00000005771	ENSPFOP00000025548	VPS39 subunit of HOPS complex.	Uncharacterized protein.	0.677
ENSPFOP00000005771	LOC103132063	ENSPFOP00000005771	ENSPFOP00000004875	VPS39 subunit of HOPS complex.	GRIP1 associated protein 1.	0.677
ENSPFOP00000005771	LOC103136815	ENSPFOP00000005771	ENSPFOP00000015025	VPS39 subunit of HOPS complex.	MON1 secretory trafficking family member Bb.	0.647
ENSPFOP00000005771	armc5	ENSPFOP00000005771	ENSPFOP00000013360	VPS39 subunit of HOPS complex.	Armadillo repeat containing 5.	0.729
ENSPFOP00000005771	ccz1	ENSPFOP00000005771	ENSPFOP00000013371	VPS39 subunit of HOPS complex.	CCZ1 homolog, vacuolar protein trafficking and biogenesis associated.	0.978
ENSPFOP00000005771	mon1a	ENSPFOP00000005771	ENSPFOP00000007064	VPS39 subunit of HOPS complex.	MON1 secretory trafficking family member A.	0.647
ENSPFOP00000005771	tgfbrap1	ENSPFOP00000005771	ENSPFOP00000011314	VPS39 subunit of HOPS complex.	Transforming growth factor, beta receptor associated protein 1.	0.977
ENSPFOP00000005771	vipas39	ENSPFOP00000005771	ENSPFOP00000016991	VPS39 subunit of HOPS complex.	VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog.	0.628
ENSPFOP00000005771	vps11	ENSPFOP00000005771	ENSPFOP00000014892	VPS39 subunit of HOPS complex.	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family.	0.999
ENSPFOP00000005771	vps18	ENSPFOP00000005771	ENSPFOP00000013047	VPS39 subunit of HOPS complex.	VPS18 core subunit of CORVET and HOPS complexes.	0.999
ENSPFOP00000005771	vps33a	ENSPFOP00000005771	ENSPFOP00000014775	VPS39 subunit of HOPS complex.	VPS33A core subunit of CORVET and HOPS complexes; Belongs to the STXBP/unc-18/SEC1 family.	0.999
ENSPFOP00000005771	vps33b	ENSPFOP00000005771	ENSPFOP00000011124	VPS39 subunit of HOPS complex.	VPS33B late endosome and lysosome associated; Belongs to the STXBP/unc-18/SEC1 family.	0.984
ENSPFOP00000005771	vps41	ENSPFOP00000005771	ENSPFOP00000013850	VPS39 subunit of HOPS complex.	Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family.	0.999
ENSPFOP00000005771	vps8	ENSPFOP00000005771	ENSPFOP00000015293	VPS39 subunit of HOPS complex.	VPS8 subunit of CORVET complex.	0.950
ENSPFOP00000006527	ENSPFOP00000005771	ENSPFOP00000006527	ENSPFOP00000005771	Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family.	VPS39 subunit of HOPS complex.	0.999
ENSPFOP00000006527	ENSPFOP00000025548	ENSPFOP00000006527	ENSPFOP00000025548	Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family.	Uncharacterized protein.	0.449
ENSPFOP00000006527	LOC103132063	ENSPFOP00000006527	ENSPFOP00000004875	Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family.	GRIP1 associated protein 1.	0.449
ENSPFOP00000006527	LOC103136815	ENSPFOP00000006527	ENSPFOP00000015025	Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family.	MON1 secretory trafficking family member Bb.	0.457
ENSPFOP00000006527	armc5	ENSPFOP00000006527	ENSPFOP00000013360	Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family.	Armadillo repeat containing 5.	0.887