(39 nodes) Mixed, incl. Stress-activated MAPK cascade, and Mitogen-activated protein (MAP) kinase phosphatase network (Poecilia formosa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103152767	Mitogen-activated protein kinase. (364 aa)
	ENSPFOP00000001749	Dual specificity phosphatase 16. (635 aa)
	ENSPFOP00000002132	ETS domain-containing protein. (504 aa)
	LOC103151778	Mitogen-activated protein kinase. (362 aa)
	LOC103151779	Mitogen-activated protein kinase. (361 aa)
	LOC103144386	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
	mapk10	Mitogen-activated protein kinase. (426 aa)
	ENSPFOP00000006593	Mitogen-activated protein kinase 8 interacting protein 3. (1306 aa)
	MAP2K6	Mitogen-activated protein kinase kinase 6. (336 aa)
	map2k7	Mitogen-activated protein kinase kinase 7. (439 aa)
	LOC103135541	Mitogen-activated protein kinase. (420 aa)
	ENSPFOP00000008202	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (410 aa)
	rerg	RAS like estrogen regulated growth inhibitor. (200 aa)
	ENSPFOP00000009279	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (372 aa)
	ENSPFOP00000009770	Uncharacterized protein. (1008 aa)
	ENSPFOP00000010893	Si:dkey-17m8.1. (987 aa)
	ENSPFOP00000011001	Protein tyrosine phosphatase receptor type R. (537 aa)
	dusp7	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (384 aa)
	LOC103150707	Mitogen-activated protein kinase kinase 6. (381 aa)
	spag9	Sperm associated antigen 9a. (1292 aa)
	LOC103156236	Uncharacterized protein. (406 aa)
	dusp8	Dual specificity phosphatase 8a. (680 aa)
	ENSPFOP00000013739	Protein tyrosine phosphatase non-receptor type 5. (407 aa)
	LOC103149217	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (218 aa)
	dusp6	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (385 aa)
	ENSPFOP00000015175	Mitogen-activated protein kinase 8 interacting protein 1a. (579 aa)
	LOC103150485	Mitogen-activated protein kinase. (368 aa)
	DUSP3	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (219 aa)
	mapk8	Mitogen-activated protein kinase. (384 aa)
	mapk8ip2	Mitogen-activated protein kinase 8 interacting protein 2. (1272 aa)
	SPAG9	Sperm associated antigen 9. (1351 aa)
	dusp10	Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (476 aa)
	map2k4	Mitogen-activated protein kinase kinase 4b; Belongs to the protein kinase superfamily. (418 aa)
	ENSPFOP00000019114	Si:dkey-175m17.7. (881 aa)
	nrarp	NOTCH regulated ankyrin repeat protein a. (112 aa)
	dusp5	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (376 aa)
	ENSPFOP00000027532	Uncharacterized protein. (211 aa)
	ENSPFOP00000027836	Si:ch211-195b15.8. (327 aa)
	MAPK8IP1	Mitogen-activated protein kinase 8 interacting protein 1. (781 aa)

Your Current Organism:

Poecilia formosa

NCBI taxonomy Id: 48698
Other names: Amazon molly, Limia formosa, Mollienesia formosa, P. formosa

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DUSP3	ENSPFOP00000008202	ENSPFOP00000017656	ENSPFOP00000008202	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.949
DUSP3	ENSPFOP00000009279	ENSPFOP00000017656	ENSPFOP00000009279	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.448
DUSP3	ENSPFOP00000011001	ENSPFOP00000017656	ENSPFOP00000011001	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Protein tyrosine phosphatase receptor type R.	0.936
DUSP3	ENSPFOP00000013739	ENSPFOP00000017656	ENSPFOP00000013739	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Protein tyrosine phosphatase non-receptor type 5.	0.929
DUSP3	LOC103135541	ENSPFOP00000017656	ENSPFOP00000007674	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase.	0.935
DUSP3	LOC103144386	ENSPFOP00000017656	ENSPFOP00000004687	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.930
DUSP3	LOC103149217	ENSPFOP00000017656	ENSPFOP00000014143	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.923
DUSP3	LOC103150485	ENSPFOP00000017656	ENSPFOP00000016323	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase.	0.923
DUSP3	LOC103151778	ENSPFOP00000017656	ENSPFOP00000002775	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase.	0.868
DUSP3	LOC103151779	ENSPFOP00000017656	ENSPFOP00000002848	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase.	0.902
DUSP3	LOC103152767	ENSPFOP00000017656	ENSPFOP00000001513	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase.	0.923
DUSP3	LOC103156236	ENSPFOP00000017656	ENSPFOP00000012651	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Uncharacterized protein.	0.917
DUSP3	dusp6	ENSPFOP00000017656	ENSPFOP00000014744	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.448
DUSP3	dusp7	ENSPFOP00000017656	ENSPFOP00000011341	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.448
DUSP3	map2k7	ENSPFOP00000017656	ENSPFOP00000007380	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase kinase 7.	0.408
DUSP3	mapk10	ENSPFOP00000017656	ENSPFOP00000005933	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase.	0.934
DUSP3	mapk8	ENSPFOP00000017656	ENSPFOP00000017722	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase.	0.932
ENSPFOP00000001749	ENSPFOP00000008202	ENSPFOP00000001749	ENSPFOP00000008202	Dual specificity phosphatase 16.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.942
ENSPFOP00000001749	ENSPFOP00000009279	ENSPFOP00000001749	ENSPFOP00000009279	Dual specificity phosphatase 16.	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.528
ENSPFOP00000001749	ENSPFOP00000009770	ENSPFOP00000001749	ENSPFOP00000009770	Dual specificity phosphatase 16.	Uncharacterized protein.	0.428