(68 nodes) Mixed, incl. Toll-like receptor signaling pathway, and TNF signaling network (Poecilia formosa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	sting1	Transmembrane protein 173. (395 aa)
	LOC103129854	Toll-like receptor 9; Belongs to the Toll-like receptor family. (1059 aa)
	tlr2	Toll-like receptor 2; Belongs to the Toll-like receptor family. (812 aa)
	TLR5	Toll like receptor 5; Belongs to the Toll-like receptor family. (892 aa)
	tradd	Tnfrsf1a-associated via death domain. (292 aa)
	tbk1	TANK-binding kinase 1. (721 aa)
	ENSPFOP00000002885	Interferon regulatory factor 3. (460 aa)
	casp7	Caspase 7, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (320 aa)
	tirap	Toll-interleukin 1 receptor (TIR) domain containing adaptor protein. (231 aa)
	irf7	Interferon regulatory factor 7. (439 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (580 aa)
	ENSPFOP00000003978	TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (700 aa)
	tab1	TGF-beta activated kinase 1/MAP3K7 binding protein 1. (496 aa)
	LOC103140531	TIR domain-containing protein; Belongs to the Toll-like receptor family. (957 aa)
	LOC103140530	Toll-like receptor 22; Belongs to the Toll-like receptor family. (960 aa)
	ENSPFOP00000004812	NIMA-related kinase 10. (825 aa)
	LOC103148929	TRIF-NTD domain-containing protein. (565 aa)
	ENSPFOP00000004936	TRIF-NTD domain-containing protein. (571 aa)
	ENSPFOP00000005525	Baculoviral IAP repeat containing 7. (483 aa)
	ENSPFOP00000005811	Toll-like receptor 3; Belongs to the Toll-like receptor family. (916 aa)
	LOC103134441	Interleukin-1 receptor-associated kinase 4. (462 aa)
	ENSPFOP00000007229	Interleukin-1 receptor-associated kinase 4. (471 aa)
	LOC103148514	Diablo, IAP-binding mitochondrial protein a. (233 aa)
	LOC103148515	Diablo, IAP-binding mitochondrial protein a. (251 aa)
	LOC103141143	Baculoviral IAP repeat containing 5b. (148 aa)
	ENSPFOP00000008989	Toll interacting protein. (276 aa)
	traf3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (590 aa)
	LOC103138778	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (491 aa)
	ENSPFOP00000011047	Toll-like receptor 22. (585 aa)
	ENSPFOP00000011095	TIR domain-containing protein. (882 aa)
	pidd1	P53-induced death domain protein 1. (940 aa)
	ENSPFOP00000012753	Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (460 aa)
	ikbkb	Inhibitor of nuclear factor kappa B kinase subunit beta. (743 aa)
	map3k20	Uncharacterized protein. (796 aa)
	map3k7	Mitogen-activated protein kinase kinase kinase 7. (600 aa)
	ENSPFOP00000013375	ADP-ribosylation factor 2b. (844 aa)
	ENSPFOP00000013438	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (290 aa)
	ENSPFOP00000013493	Protein kinase domain-containing protein. (475 aa)
	tnfrsf1a	Tumor necrosis factor receptor superfamily, member 1a. (379 aa)
	tab3	TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (573 aa)
	faslg	Fas ligand (TNF superfamily, member 6); Belongs to the tumor necrosis factor family. (275 aa)
	ENSPFOP00000014923	Mitogen-activated protein kinase kinase kinase 14a. (849 aa)
	LOC103151557	Uncharacterized protein; Belongs to the peptidase C14A family. (456 aa)
	ENSPFOP00000015035	Uncharacterized protein; Belongs to the peptidase C14A family. (388 aa)
	ENSPFOP00000015097	Caspase 10, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (555 aa)
	ENSPFOP00000015630	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like. (703 aa)
	LOC103133531	Uncharacterized protein. (327 aa)
	LOC103149873	Transmembrane p24 trafficking protein 3. (207 aa)
	ikbkg	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (583 aa)
	ikbke	Inhibitor of nuclear factor kappa B kinase subunit epsilon. (735 aa)
	tank	TRAF family member-associated NFKB activator. (336 aa)
	LOC103151629	Si:ch211-149b19.3. (375 aa)
	ENSPFOP00000018243	Uncharacterized protein; Belongs to the protein kinase superfamily. (460 aa)
	birc2	Baculoviral IAP repeat containing 2. (642 aa)
	cflar	Uncharacterized protein; Belongs to the peptidase C14A family. (423 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (763 aa)
	traf6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa)
	traf2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa)
	LOC103135488	Toll-like receptor 1. (802 aa)
	ENSPFOP00000020731	Uncharacterized protein. (648 aa)
	ENSPFOP00000022883	Uncharacterized protein. (217 aa)
	LOC103139935	X-linked inhibitor of apoptosis. (401 aa)
	irak1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (423 aa)
	ENSPFOP00000024685	TIR domain-containing protein. (951 aa)
	ENSPFOP00000025729	Toll-like receptor 7; Belongs to the Toll-like receptor family. (1060 aa)
	TLR8	Toll like receptor 8; Belongs to the Toll-like receptor family. (1026 aa)
	LOC103147021	Protein kinase domain-containing protein. (674 aa)
	unc93b1	Unc-93 homolog B1, TLR signaling regulator. (621 aa)

Your Current Organism:

Poecilia formosa

NCBI taxonomy Id: 48698
Other names: Amazon molly, Limia formosa, Mollienesia formosa, P. formosa

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHUK	ENSPFOP00000002885	ENSPFOP00000018648	ENSPFOP00000002885	Component of inhibitor of nuclear factor kappa B kinase complex.	Interferon regulatory factor 3.	0.613
CHUK	ENSPFOP00000003978	ENSPFOP00000018648	ENSPFOP00000003978	Component of inhibitor of nuclear factor kappa B kinase complex.	TGF-beta activated kinase 1 (MAP3K7) binding protein 2.	0.967
CHUK	ENSPFOP00000004812	ENSPFOP00000018648	ENSPFOP00000004812	Component of inhibitor of nuclear factor kappa B kinase complex.	NIMA-related kinase 10.	0.508
CHUK	ENSPFOP00000004936	ENSPFOP00000018648	ENSPFOP00000004936	Component of inhibitor of nuclear factor kappa B kinase complex.	TRIF-NTD domain-containing protein.	0.569
CHUK	ENSPFOP00000005525	ENSPFOP00000018648	ENSPFOP00000005525	Component of inhibitor of nuclear factor kappa B kinase complex.	Baculoviral IAP repeat containing 7.	0.709
CHUK	ENSPFOP00000005811	ENSPFOP00000018648	ENSPFOP00000005811	Component of inhibitor of nuclear factor kappa B kinase complex.	Toll-like receptor 3; Belongs to the Toll-like receptor family.	0.536
CHUK	ENSPFOP00000007229	ENSPFOP00000018648	ENSPFOP00000007229	Component of inhibitor of nuclear factor kappa B kinase complex.	Interleukin-1 receptor-associated kinase 4.	0.926
CHUK	ENSPFOP00000011047	ENSPFOP00000018648	ENSPFOP00000011047	Component of inhibitor of nuclear factor kappa B kinase complex.	Toll-like receptor 22.	0.430
CHUK	ENSPFOP00000011095	ENSPFOP00000018648	ENSPFOP00000011095	Component of inhibitor of nuclear factor kappa B kinase complex.	TIR domain-containing protein.	0.499
CHUK	ENSPFOP00000013375	ENSPFOP00000018648	ENSPFOP00000013375	Component of inhibitor of nuclear factor kappa B kinase complex.	ADP-ribosylation factor 2b.	0.981
CHUK	ENSPFOP00000013438	ENSPFOP00000018648	ENSPFOP00000013438	Component of inhibitor of nuclear factor kappa B kinase complex.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.659
CHUK	ENSPFOP00000013493	ENSPFOP00000018648	ENSPFOP00000013493	Component of inhibitor of nuclear factor kappa B kinase complex.	Protein kinase domain-containing protein.	0.515
CHUK	ENSPFOP00000014923	ENSPFOP00000018648	ENSPFOP00000014923	Component of inhibitor of nuclear factor kappa B kinase complex.	Mitogen-activated protein kinase kinase kinase 14a.	0.969
CHUK	ENSPFOP00000015630	ENSPFOP00000018648	ENSPFOP00000015630	Component of inhibitor of nuclear factor kappa B kinase complex.	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like.	0.951
CHUK	ENSPFOP00000018243	ENSPFOP00000018648	ENSPFOP00000018243	Component of inhibitor of nuclear factor kappa B kinase complex.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.663
CHUK	ENSPFOP00000020731	ENSPFOP00000018648	ENSPFOP00000020731	Component of inhibitor of nuclear factor kappa B kinase complex.	Uncharacterized protein.	0.426
CHUK	ENSPFOP00000022883	ENSPFOP00000018648	ENSPFOP00000022883	Component of inhibitor of nuclear factor kappa B kinase complex.	Uncharacterized protein.	0.911
CHUK	ENSPFOP00000024685	ENSPFOP00000018648	ENSPFOP00000024685	Component of inhibitor of nuclear factor kappa B kinase complex.	TIR domain-containing protein.	0.499
CHUK	ENSPFOP00000025729	ENSPFOP00000018648	ENSPFOP00000025729	Component of inhibitor of nuclear factor kappa B kinase complex.	Toll-like receptor 7; Belongs to the Toll-like receptor family.	0.430
CHUK	LOC103129854	ENSPFOP00000018648	ENSPFOP00000000377	Component of inhibitor of nuclear factor kappa B kinase complex.	Toll-like receptor 9; Belongs to the Toll-like receptor family.	0.496