(66 nodes) Protease binding network (Poecilia formosa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	nfrkb	Nuclear factor related to kappaB binding protein. (1277 aa)
	ENSPFOP00000014254	RING-CH-type domain-containing protein. (923 aa)
	amfr	Autocrine motility factor receptor b. (622 aa)
	trip4	Thyroid hormone receptor interactor 4. (573 aa)
	polg	Polymerase (DNA directed), gamma. (1195 aa)
	flot1	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
	LOC103143131	Integrin, alpha 3b; Belongs to the integrin alpha chain family. (1058 aa)
	ecm1	Uncharacterized protein. (483 aa)
	psap	Prosaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. (536 aa)
	twnk	Twinkle mtDNA helicase. (721 aa)
	ENSPFOP00000016861	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1638 aa)
	ENSPFOP00000018006	Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1046 aa)
	cflar	Uncharacterized protein; Belongs to the peptidase C14A family. (423 aa)
	LOC103133852	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (432 aa)
	ENSPFOP00000019155	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (255 aa)
	BDKRB2	Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (336 aa)
	bcl2	BCL2 apoptosis regulator b. (229 aa)
	ENSPFOP00000021254	Uncharacterized protein. (610 aa)
	ENSPFOP00000022296	TIMP metallopeptidase inhibitor 2b. (222 aa)
	ENSPFOP00000024419	Clathrin, heavy chain-like 1. (1220 aa)
	LOC103139701	Cystatin domain-containing protein; Belongs to the cystatin family. (99 aa)
	ENSPFOP00000000057	DBB domain-containing protein. (602 aa)
	LOC103131656	Uncharacterized protein. (290 aa)
	LOC103156615	SERPIN domain-containing protein; Belongs to the serpin family. (428 aa)
	ENSPFOP00000000986	Charged multivesicular body protein 3. (223 aa)
	rnf139	Ring finger protein 139. (701 aa)
	LOC103146382	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (424 aa)
	brca2	BRCA2 DNA repair associated. (3036 aa)
	MARCHF6	Membrane associated ring-CH-type finger 6. (915 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (580 aa)
	ENSPFOP00000003818	SERPIN domain-containing protein; Belongs to the serpin family. (471 aa)
	LOC103147841	MALT paracaspase 3. (645 aa)
	LOC103152943	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa)
	ENSPFOP00000005486	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (440 aa)
	serpinc1	Serpin peptidase inhibitor, clade C (antithrombin), member 1; Belongs to the serpin family. (449 aa)
	LOC103145329	Fibronectin 1a. (2502 aa)
	yipf5	Protein YIPF. (257 aa)
	ENSPFOP00000005752	Uncharacterized protein. (346 aa)
	LOC103138749	Zgc:123321. (235 aa)
	LOC103152816	Uncharacterized protein. (377 aa)
	malt1	MALT paracaspase 1. (828 aa)
	LOC103156882	MALT paracaspase 2. (819 aa)
	pink1	PTEN induced kinase 1. (575 aa)
	TIMP3	TIMP metallopeptidase inhibitor 3. (214 aa)
	fbxo45	F-box protein 45. (290 aa)
	F3	Coagulation factor IIIa. (279 aa)
	ENSPFOP00000009558	Selenoprotein S. (191 aa)
	ENSPFOP00000010254	Surfactant protein Bb. (364 aa)
	ADRM1	Adhesion regulating molecule 1. (414 aa)
	ENSPFOP00000012105	Adhesion regulating molecule 1. (422 aa)
	ENSPFOP00000012188	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family. (380 aa)
	ENSPFOP00000012340	TIMP metallopeptidase inhibitor 2a. (222 aa)
	ENSPFOP00000012448	PDZ domain containing 3b. (491 aa)
	tnfaip3	Tumor necrosis factor, alpha-induced protein 3. (824 aa)
	cltc	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1685 aa)
	timp4	TIMP metallopeptidase inhibitor 4, tandem duplicate 2. (224 aa)
	BFAR	Bifunctional apoptosis regulator. (457 aa)
	casp8ap2	Uncharacterized protein. (1810 aa)
	tysnd1	Trypsin domain containing 1. (516 aa)
	ENSPFOP00000025837	Serine/threonine-protein kinase RIO3; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (508 aa)
	LOC103145869	Uncharacterized protein. (95 aa)
	ENSPFOP00000026293	Cystatin domain-containing protein. (103 aa)
	ENSPFOP00000026804	Uncharacterized protein. (100 aa)
	ENSPFOP00000028156	Uncharacterized protein. (100 aa)
	bcl2l10	BCL2 like 10. (216 aa)
	ENSPFOP00000030674	IGv domain-containing protein. (197 aa)

Your Current Organism:

Poecilia formosa

NCBI taxonomy Id: 48698
Other names: Amazon molly, Limia formosa, Mollienesia formosa, P. formosa

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADRM1	ENSPFOP00000005486	ENSPFOP00000012005	ENSPFOP00000005486	Adhesion regulating molecule 1.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.874
ADRM1	tysnd1	ENSPFOP00000012005	ENSPFOP00000013649	Adhesion regulating molecule 1.	Trypsin domain containing 1.	0.627
ENSPFOP00000000057	ripk2	ENSPFOP00000000057	ENSPFOP00000003613	DBB domain-containing protein.	Receptor-interacting serine-threonine kinase 2.	0.509
ENSPFOP00000003818	serpinc1	ENSPFOP00000003818	ENSPFOP00000005544	SERPIN domain-containing protein; Belongs to the serpin family.	Serpin peptidase inhibitor, clade C (antithrombin), member 1; Belongs to the serpin family.	0.707
ENSPFOP00000005486	ADRM1	ENSPFOP00000005486	ENSPFOP00000012005	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	Adhesion regulating molecule 1.	0.874
ENSPFOP00000005486	ENSPFOP00000012105	ENSPFOP00000005486	ENSPFOP00000012105	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	Adhesion regulating molecule 1.	0.874
ENSPFOP00000005486	LOC103145329	ENSPFOP00000005486	ENSPFOP00000005553	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	Fibronectin 1a.	0.492
ENSPFOP00000005486	bcl2	ENSPFOP00000005486	ENSPFOP00000021079	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	BCL2 apoptosis regulator b.	0.729
ENSPFOP00000005486	bcl2l10	ENSPFOP00000005486	ENSPFOP00000029643	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	BCL2 like 10.	0.696
ENSPFOP00000005486	pink1	ENSPFOP00000005486	ENSPFOP00000007937	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	PTEN induced kinase 1.	0.999
ENSPFOP00000005486	polg	ENSPFOP00000005486	ENSPFOP00000014941	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	Polymerase (DNA directed), gamma.	0.483
ENSPFOP00000005486	ripk2	ENSPFOP00000005486	ENSPFOP00000003613	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	Receptor-interacting serine-threonine kinase 2.	0.626
ENSPFOP00000005486	tysnd1	ENSPFOP00000005486	ENSPFOP00000013649	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	Trypsin domain containing 1.	0.754
ENSPFOP00000009558	ENSPFOP00000019155	ENSPFOP00000009558	ENSPFOP00000019155	Selenoprotein S.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.946
ENSPFOP00000009558	amfr	ENSPFOP00000009558	ENSPFOP00000014596	Selenoprotein S.	Autocrine motility factor receptor b.	0.476
ENSPFOP00000010254	ENSPFOP00000016861	ENSPFOP00000010254	ENSPFOP00000016861	Surfactant protein Bb.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.421
ENSPFOP00000010254	ENSPFOP00000024419	ENSPFOP00000010254	ENSPFOP00000024419	Surfactant protein Bb.	Clathrin, heavy chain-like 1.	0.421
ENSPFOP00000010254	LOC103145869	ENSPFOP00000010254	ENSPFOP00000025840	Surfactant protein Bb.	Uncharacterized protein.	0.421
ENSPFOP00000010254	cltc	ENSPFOP00000010254	ENSPFOP00000012720	Surfactant protein Bb.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.421
ENSPFOP00000012105	ENSPFOP00000005486	ENSPFOP00000012105	ENSPFOP00000005486	Adhesion regulating molecule 1.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.874