(58 nodes) Cardiac ventricle development network (Poecilia formosa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSPFOP00000029965	Uncharacterized protein. (156 aa)
	ENSPFOP00000000651	NK2 homeobox 5. (313 aa)
	ENSPFOP00000000657	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
	arnt2	Aryl-hydrocarbon receptor nuclear translocator 2. (589 aa)
	ENSPFOP00000000928	Neuropeptide Y receptor Y2, like. (403 aa)
	tmem65	Transmembrane protein 65. (240 aa)
	fgf8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	sall4	Spalt-like transcription factor 4. (1081 aa)
	med1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1793 aa)
	ENSPFOP00000002689	Troponin I type 1a (skeletal, slow). (187 aa)
	ENSPFOP00000003054	PR domain containing 1b, with ZNF domain. (647 aa)
	ENSPFOP00000003632	Nuclear receptor binding SET domain protein 2. (1301 aa)
	LOC103153475	Troponin C type 1b (slow). (161 aa)
	LOC103153475-2	Troponin C, slow skeletal and cardiac muscles-like. (161 aa)
	bmpr2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1041 aa)
	LOC103136619	Aryl hydrocarbon receptor nuclear translocator. (796 aa)
	ENSPFOP00000005456	Neuropeptide Y receptor Y2; Belongs to the G-protein coupled receptor 1 family. (331 aa)
	ccn1	Cellular communication network factor 1. (376 aa)
	LOC103142634	Uncharacterized protein. (672 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (536 aa)
	LOC103146173	Mothers against decapentaplegic homolog. (506 aa)
	ENSPFOP00000006652	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (209 aa)
	hace1	HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1. (897 aa)
	cpe	Carboxypeptidase E. (456 aa)
	LOC103136959	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (593 aa)
	ENSPFOP00000008511	Uncharacterized protein. (311 aa)
	smad6	Mothers against decapentaplegic homolog. (490 aa)
	dctn5	Dynactin 5. (182 aa)
	ENSPFOP00000008867	Uncharacterized protein. (472 aa)
	ednra	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family. (444 aa)
	smad7	Mothers against decapentaplegic homolog. (378 aa)
	TNNC1	Troponin C1, slow skeletal and cardiac type. (162 aa)
	nprl3	NPR3-like, GATOR1 complex subunit. (596 aa)
	trip11	Thyroid hormone receptor interactor 11. (1953 aa)
	LOC103138120	Myostatin b. (378 aa)
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	HAND1	Heart and neural crest derivatives expressed 1. (194 aa)
	zmpste24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (471 aa)
	ENSPFOP00000014035	Zinc finger protein, FOG family member 2a. (988 aa)
	ENSPFOP00000014290	Troponin I type 1b (skeletal, slow). (170 aa)
	ENSPFOP00000015343	Growth regulating estrogen receptor binding 1. (2000 aa)
	LOC103138264	Transforming growth factor beta; Belongs to the TGF-beta family. (380 aa)
	ENSPFOP00000016013	Mesoderm posterior ba. (248 aa)
	ENSPFOP00000016051	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1009 aa)
	LOC103135153	Uncharacterized protein. (257 aa)
	sema3c	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C; Belongs to the semaphorin family. (747 aa)
	ENSPFOP00000018268	Endothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family. (369 aa)
	prdm1	PR domain containing 1a, with ZNF domain. (844 aa)
	hectd1	HECT domain containing 1. (2572 aa)
	PTK7	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1023 aa)
	LOC103134364	Uncharacterized protein. (783 aa)
	LOC103149412	Mothers against decapentaplegic homolog. (503 aa)
	ENSPFOP00000019951	T-box transcription factor 5a. (525 aa)
	ENSPFOP00000019994	Mothers against decapentaplegic homolog. (511 aa)
	ENSPFOP00000020626	Neuropeptide Y receptor Y7; Belongs to the G-protein coupled receptor 1 family. (350 aa)
	ENSPFOP00000023954	Myostatin b. (358 aa)
	SMAD4	Mothers against decapentaplegic homolog. (510 aa)
	sav1	Salvador family WW domain containing protein 1. (396 aa)

Your Current Organism:

Poecilia formosa

NCBI taxonomy Id: 48698
Other names: Amazon molly, Limia formosa, Mollienesia formosa, P. formosa

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPFOP00000000651	ENSPFOP00000000657	ENSPFOP00000000651	ENSPFOP00000000657	NK2 homeobox 5.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.426
ENSPFOP00000000651	ENSPFOP00000003632	ENSPFOP00000000651	ENSPFOP00000003632	NK2 homeobox 5.	Nuclear receptor binding SET domain protein 2.	0.647
ENSPFOP00000000651	ENSPFOP00000006652	ENSPFOP00000000651	ENSPFOP00000006652	NK2 homeobox 5.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.426
ENSPFOP00000000651	ENSPFOP00000016013	ENSPFOP00000000651	ENSPFOP00000016013	NK2 homeobox 5.	Mesoderm posterior ba.	0.473
ENSPFOP00000000651	ENSPFOP00000019951	ENSPFOP00000000651	ENSPFOP00000019951	NK2 homeobox 5.	T-box transcription factor 5a.	0.898
ENSPFOP00000000651	HAND1	ENSPFOP00000000651	ENSPFOP00000012599	NK2 homeobox 5.	Heart and neural crest derivatives expressed 1.	0.552
ENSPFOP00000000651	fgf8	ENSPFOP00000000651	ENSPFOP00000001274	NK2 homeobox 5.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.428
ENSPFOP00000000657	ENSPFOP00000000651	ENSPFOP00000000657	ENSPFOP00000000651	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	NK2 homeobox 5.	0.426
ENSPFOP00000002689	LOC103153475	ENSPFOP00000002689	ENSPFOP00000004071	Troponin I type 1a (skeletal, slow).	Troponin C type 1b (slow).	0.926
ENSPFOP00000002689	LOC103153475-2	ENSPFOP00000002689	ENSPFOP00000004130	Troponin I type 1a (skeletal, slow).	Troponin C, slow skeletal and cardiac muscles-like.	0.926
ENSPFOP00000002689	TNNC1	ENSPFOP00000002689	ENSPFOP00000009242	Troponin I type 1a (skeletal, slow).	Troponin C1, slow skeletal and cardiac type.	0.926
ENSPFOP00000003054	ENSPFOP00000003632	ENSPFOP00000003054	ENSPFOP00000003632	PR domain containing 1b, with ZNF domain.	Nuclear receptor binding SET domain protein 2.	0.534
ENSPFOP00000003632	ENSPFOP00000000651	ENSPFOP00000003632	ENSPFOP00000000651	Nuclear receptor binding SET domain protein 2.	NK2 homeobox 5.	0.647
ENSPFOP00000003632	ENSPFOP00000003054	ENSPFOP00000003632	ENSPFOP00000003054	Nuclear receptor binding SET domain protein 2.	PR domain containing 1b, with ZNF domain.	0.534
ENSPFOP00000003632	LOC103134364	ENSPFOP00000003632	ENSPFOP00000019495	Nuclear receptor binding SET domain protein 2.	Uncharacterized protein.	0.534
ENSPFOP00000003632	PTK7	ENSPFOP00000003632	ENSPFOP00000019384	Nuclear receptor binding SET domain protein 2.	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.436
ENSPFOP00000003632	prdm1	ENSPFOP00000003632	ENSPFOP00000018402	Nuclear receptor binding SET domain protein 2.	PR domain containing 1a, with ZNF domain.	0.534
ENSPFOP00000003632	sall4	ENSPFOP00000003632	ENSPFOP00000001359	Nuclear receptor binding SET domain protein 2.	Spalt-like transcription factor 4.	0.617
ENSPFOP00000006652	ENSPFOP00000000651	ENSPFOP00000006652	ENSPFOP00000000651	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	NK2 homeobox 5.	0.426
ENSPFOP00000008511	PTK7	ENSPFOP00000008511	ENSPFOP00000019384	Uncharacterized protein.	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.617