(112 nodes) Negative regulation of cell development network (Poecilia formosa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103155738	Si:dkey-49n23.1; Belongs to the semaphorin family. (800 aa)
	ENSPFOP00000031251	Spartin b. (461 aa)
	ENSPFOP00000030320	Disco-interacting protein 2 homolog Bb. (1583 aa)
	ENSPFOP00000029262	Uncharacterized protein. (252 aa)
	ENSPFOP00000028580	Uncharacterized protein. (400 aa)
	LOC103133113	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fa. (416 aa)
	LOC103132512	Sema domain-containing protein; Belongs to the semaphorin family. (437 aa)
	ENSPFOP00000024697	Sema domain-containing protein. (1086 aa)
	LOC103131732	Uncharacterized protein. (478 aa)
	LOC103143784	G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (352 aa)
	ENSPFOP00000020767	Inhibitor of DNA binding 1, HLH protein. (116 aa)
	SEMA4F	Ssemaphorin 4F; Belongs to the semaphorin family. (872 aa)
	ENSPFOP00000020110	Neurogenin 1. (206 aa)
	brinp1	Bone morphogenetic protein/retinoic acid inducible neural-specific 1. (761 aa)
	ulk1	Unc-51 like autophagy activating kinase 1. (1023 aa)
	dynlt1	Dynein, light chain, Tctex-type 1. (154 aa)
	rapgef2	Rap guanine nucleotide exchange factor (GEF) 2. (1590 aa)
	sema3d	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D; Belongs to the semaphorin family. (804 aa)
	dip2a	Disco-interacting protein 2 homolog A. (1584 aa)
	sema3a	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Ab; Belongs to the semaphorin family. (801 aa)
	LOC103133769	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E; Belongs to the semaphorin family. (794 aa)
	ENSPFOP00000018431	Si:ch211-113g11.6; Belongs to the semaphorin family. (568 aa)
	igf1	Insulin-like growth factor 1. (186 aa)
	wnt3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	sema6b	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Bb; Belongs to the semaphorin family. (868 aa)
	LOC103148389	Unc-51 like autophagy activating kinase 1a. (892 aa)
	sema4b	Uncharacterized protein; Belongs to the semaphorin family. (838 aa)
	LOC103140233	Pleiotrophin. (161 aa)
	sema3c	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C; Belongs to the semaphorin family. (747 aa)
	ulk2	Unc-51 like autophagy activating kinase 2. (1040 aa)
	ENSPFOP00000016691	Uncharacterized protein; Belongs to the semaphorin family. (887 aa)
	ENSPFOP00000016688	Sema domain-containing protein. (995 aa)
	sema4a	Sema domain-containing protein; Belongs to the semaphorin family. (820 aa)
	LOC103138389	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fa; Belongs to the semaphorin family. (542 aa)
	LOC103134971	Reticulon 4 receptor. (467 aa)
	nf2	Neurofibromin 2a (merlin). (591 aa)
	LOC103149862	Uncharacterized protein; Belongs to the semaphorin family. (611 aa)
	LOC103145089	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
	LOC103151569	Endothelin receptor Ba; Belongs to the G-protein coupled receptor 1 family. (425 aa)
	ENSPFOP00000014724	Eph receptor A4, like. (991 aa)
	ski	V-ski avian sarcoma viral oncogene homolog a. (718 aa)
	ifrd1	Interferon-related developmental regulator 1. (428 aa)
	cdk5	Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
	ENSPFOP00000012986	Ring finger protein 10. (803 aa)
	ENSPFOP00000012978	Disco-interacting protein 2 homolog Ba. (1552 aa)
	LOC103151236	Semaphorin 4e; Belongs to the semaphorin family. (753 aa)
	LOC103148876	Si:ch73-40a2.1. (888 aa)
	ENSPFOP00000012615	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
	ENSPFOP00000012382	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (274 aa)
	LOC103151230	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Ba; Belongs to the semaphorin family. (899 aa)
	ENSPFOP00000012176	Nuclear factor of activated T cells 4. (368 aa)
	wnt7b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	ENSPFOP00000011354	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D; Belongs to the semaphorin family. (1101 aa)
	LOC103139469	Neurofibromin 2b (merlin). (591 aa)
	med23	Mediator complex subunit 23. (1409 aa)
	ENSPFOP00000003091	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3bl; Belongs to the semaphorin family. (705 aa)
	ENSPFOP00000010806	Uncharacterized protein. (998 aa)
	itgb1bp1	Integrin beta 1 binding protein 1. (198 aa)
	SEMA4D	Semaphorin 4D; Belongs to the semaphorin family. (892 aa)
	WNT7A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (385 aa)
	ENSPFOP00000009233	Uncharacterized protein. (1262 aa)
	LOC103153072	Nuclear receptor subfamily 1, group d, member 1. (581 aa)
	tmem98	Transmembrane protein 98. (224 aa)
	LOC103156726	Si:ch211-113g11.6; Belongs to the semaphorin family. (433 aa)
	pcm1	Pericentriolar material 1. (2111 aa)
	ENSPFOP00000007170	Sema domain-containing protein; Belongs to the semaphorin family. (415 aa)
	ENSPFOP00000007136	Sema domain-containing protein; Belongs to the semaphorin family. (672 aa)
	LOC103155171	Si:ch211-129c21.1; Belongs to the semaphorin family. (804 aa)
	ENSPFOP00000006522	Sprouty homolog 4 (Drosophila). (283 aa)
	ENSPFOP00000006472	Sema domain-containing protein. (1094 aa)
	ENSPFOP00000006229	Sema domain-containing protein; Belongs to the semaphorin family. (708 aa)
	ENSPFOP00000005988	RUN and FYVE domain containing 3. (628 aa)
	LOC103148157	Homeobox protein Nkx-6.2-like. (281 aa)
	ENSPFOP00000005890	Semaphorin 7A; Belongs to the semaphorin family. (642 aa)
	LOC103148151	NK6 homeobox 2. (281 aa)
	f2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (617 aa)
	LOC103149304	Adaptor related protein complex 1 associated regulatory protein. (299 aa)
	LOC103149456	Spartin b. (511 aa)
	ENSPFOP00000005457	Endothelin receptor type Bb; Belongs to the G-protein coupled receptor 1 family. (415 aa)
	nf1	Neurofibromin 1b. (2774 aa)
	LOC103141969	Notch receptor 1b. (2491 aa)
	ENSPFOP00000004651	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Aa; Belongs to the semaphorin family. (817 aa)
	rb1	Retinoblastoma 1. (913 aa)
	LOC103147728	Uncharacterized protein; Belongs to the semaphorin family. (880 aa)
	rflnb	Refilin B. (204 aa)
	ryk	Receptor like tyrosine kinase. (634 aa)
	ENSPFOP00000003757	Rap guanine nucleotide exchange factor (GEF) 6. (1572 aa)
	ENSPFOP00000003753	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fb; Belongs to the semaphorin family. (780 aa)
	LOC103146974	Kinesin-associated protein 3b. (783 aa)
	ENSPFOP00000003525	Kinesin-associated protein 3a. (789 aa)
	ENSPFOP00000003490	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3bl; Belongs to the semaphorin family. (767 aa)
	ENSPFOP00000003387	Uncharacterized protein; Belongs to the semaphorin family. (565 aa)
	ENSPFOP00000003386	Disco-interacting protein 2 homolog Cb. (1564 aa)
	ENSPFOP00000003259	Uncharacterized protein; Belongs to the semaphorin family. (650 aa)
	ENSPFOP00000003186	RE1-silencing transcription factor. (877 aa)
	sirt2	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (383 aa)
	ENSPFOP00000003122	Notch receptor 1a. (2477 aa)
	ttpal	Tocopherol (alpha) transfer protein-like. (345 aa)
	ENSPFOP00000000634	Transmembrane protein 98. (183 aa)
	dnajb11	DnaJ heat shock protein family (Hsp40) member B11. (360 aa)
	ENSPFOP00000000819	Tocopherol (alpha) transfer protein. (312 aa)
	sorl1	Sortilin_C domain-containing protein. (996 aa)
	ENSPFOP00000001477	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D, like; Belongs to the semaphorin family. (1113 aa)
	LOC103155923	Interferon-related developmental regulator 2. (436 aa)
	sema4c	Uncharacterized protein; Belongs to the semaphorin family. (861 aa)
	LOC103129680	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6E; Belongs to the semaphorin family. (1088 aa)
	LOC103141111	Nuclear receptor subfamily 1, group D, member 4a. (580 aa)
	ENSPFOP00000002691	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B; Belongs to the semaphorin family. (781 aa)
	nkx6-1	NK6 homeobox 1. (328 aa)
	ENSPFOP00000002818	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (421 aa)
	SEMA6A	Semaphorin 6A; Belongs to the semaphorin family. (575 aa)
	LOC103155269	Uncharacterized protein; Belongs to the semaphorin family. (770 aa)

Your Current Organism:

Poecilia formosa

NCBI taxonomy Id: 48698
Other names: Amazon molly, Limia formosa, Mollienesia formosa, P. formosa

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPFOP00000001477	ENSPFOP00000006229	ENSPFOP00000001477	ENSPFOP00000006229	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D, like; Belongs to the semaphorin family.	Sema domain-containing protein; Belongs to the semaphorin family.	0.451
ENSPFOP00000001477	LOC103155269	ENSPFOP00000001477	ENSPFOP00000003048	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D, like; Belongs to the semaphorin family.	Uncharacterized protein; Belongs to the semaphorin family.	0.451
ENSPFOP00000001477	cdk5	ENSPFOP00000001477	ENSPFOP00000013235	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D, like; Belongs to the semaphorin family.	Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily.	0.539
ENSPFOP00000001477	sema4a	ENSPFOP00000001477	ENSPFOP00000016654	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D, like; Belongs to the semaphorin family.	Sema domain-containing protein; Belongs to the semaphorin family.	0.451
ENSPFOP00000001477	sema4b	ENSPFOP00000001477	ENSPFOP00000017415	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D, like; Belongs to the semaphorin family.	Uncharacterized protein; Belongs to the semaphorin family.	0.451
ENSPFOP00000002691	ENSPFOP00000007136	ENSPFOP00000002691	ENSPFOP00000007136	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B; Belongs to the semaphorin family.	Sema domain-containing protein; Belongs to the semaphorin family.	0.437
ENSPFOP00000002691	ENSPFOP00000007170	ENSPFOP00000002691	ENSPFOP00000007170	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B; Belongs to the semaphorin family.	Sema domain-containing protein; Belongs to the semaphorin family.	0.437
ENSPFOP00000002691	LOC103132512	ENSPFOP00000002691	ENSPFOP00000025338	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B; Belongs to the semaphorin family.	Sema domain-containing protein; Belongs to the semaphorin family.	0.437
ENSPFOP00000002691	LOC103151236	ENSPFOP00000002691	ENSPFOP00000012697	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B; Belongs to the semaphorin family.	Semaphorin 4e; Belongs to the semaphorin family.	0.464
ENSPFOP00000002691	LOC103155171	ENSPFOP00000002691	ENSPFOP00000006830	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B; Belongs to the semaphorin family.	Si:ch211-129c21.1; Belongs to the semaphorin family.	0.437
ENSPFOP00000002691	SEMA4D	ENSPFOP00000002691	ENSPFOP00000009620	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B; Belongs to the semaphorin family.	Semaphorin 4D; Belongs to the semaphorin family.	0.437
ENSPFOP00000002691	cdk5	ENSPFOP00000002691	ENSPFOP00000013235	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B; Belongs to the semaphorin family.	Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily.	0.616
ENSPFOP00000002818	ENSPFOP00000005457	ENSPFOP00000002818	ENSPFOP00000005457	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Endothelin receptor type Bb; Belongs to the G-protein coupled receptor 1 family.	0.952
ENSPFOP00000002818	LOC103151569	ENSPFOP00000002818	ENSPFOP00000015235	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Endothelin receptor Ba; Belongs to the G-protein coupled receptor 1 family.	0.952
ENSPFOP00000002818	f2	ENSPFOP00000002818	ENSPFOP00000005858	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.669
ENSPFOP00000003122	ENSPFOP00000012615	ENSPFOP00000003122	ENSPFOP00000012615	Notch receptor 1a.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.417
ENSPFOP00000003259	ENSPFOP00000007136	ENSPFOP00000003259	ENSPFOP00000007136	Uncharacterized protein; Belongs to the semaphorin family.	Sema domain-containing protein; Belongs to the semaphorin family.	0.437
ENSPFOP00000003259	ENSPFOP00000007170	ENSPFOP00000003259	ENSPFOP00000007170	Uncharacterized protein; Belongs to the semaphorin family.	Sema domain-containing protein; Belongs to the semaphorin family.	0.437
ENSPFOP00000003259	LOC103132512	ENSPFOP00000003259	ENSPFOP00000025338	Uncharacterized protein; Belongs to the semaphorin family.	Sema domain-containing protein; Belongs to the semaphorin family.	0.437
ENSPFOP00000003259	LOC103151236	ENSPFOP00000003259	ENSPFOP00000012697	Uncharacterized protein; Belongs to the semaphorin family.	Semaphorin 4e; Belongs to the semaphorin family.	0.470