(52 nodes) Phenol-containing compound metabolic process network (Poecilia formosa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSPFOP00000017782	Histidine decarboxylase. (482 aa)
	ENSPFOP00000031152	Sulfotransferase; Belongs to the sulfotransferase 1 family. (296 aa)
	ENSPFOP00000030863	Tryptophan hydroxylase 2 (tryptophan 5-monooxygenase). (504 aa)
	ENSPFOP00000025954	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine). (145 aa)
	ENSPFOP00000023915	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine). (133 aa)
	TPH1	Tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) a. (480 aa)
	bcl2	BCL2 apoptosis regulator b. (229 aa)
	LOC103136569	Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. (322 aa)
	ENSPFOP00000019817	Dopamine beta-hydroxylase (dopamine beta-monooxygenase). (619 aa)
	ENSPFOP00000019482	RING-type domain-containing protein. (429 aa)
	ENSPFOP00000018268	Endothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family. (369 aa)
	ENSPFOP00000018121	Tyrosine hydroxylase 2. (474 aa)
	ddc	Dopa decarboxylase. (481 aa)
	TYR	Tyrosinase. (546 aa)
	LOC103134840	Sulfotransferase; Belongs to the sulfotransferase 1 family. (291 aa)
	ENSPFOP00000016225	Tyrosinase-related protein 1b. (549 aa)
	ENSPFOP00000015342	Crystallin, mu. (317 aa)
	DIO3	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine). (235 aa)
	trpc1	Transient receptor potential cation channel, subfamily C, member 1; Belongs to the transient receptor (TC 1.A.4) family. (805 aa)
	btbd9	BTB (POZ) domain containing 9. (613 aa)
	ENSPFOP00000014263	Oculocutaneous albinism II. (839 aa)
	th	Tyrosine hydroxylase. (489 aa)
	ctns	Cystinosin, lysosomal cystine transporter. (379 aa)
	nox5	NADPH oxidase, EF-hand calcium binding domain 5. (783 aa)
	LOC103138118	D-dopachrome tautomerase. (118 aa)
	LOC103145036	Sulfotransferase; Belongs to the sulfotransferase 1 family. (291 aa)
	LOC103145038	Sulfotransferase; Belongs to the sulfotransferase 1 family. (300 aa)
	iyd	Iodotyrosine deiodinase. (296 aa)
	LOC103149204	Uncharacterized protein. (450 aa)
	SLC16A2	Solute carrier family 16 member 2. (563 aa)
	dao	D-amino-acid oxidase, tandem duplicate 2. (345 aa)
	ENSPFOP00000010642	Amine oxidase. (383 aa)
	CPQ	Carboxypeptidase Q. (486 aa)
	LOC103145127	GTP cyclohydrolase 2. (236 aa)
	maob	Amine oxidase. (566 aa)
	ednra	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family. (444 aa)
	gch1	GTP cyclohydrolase 1. (255 aa)
	LRTOMT	Leucine rich transmembrane and O-methyltransferase domain containing. (183 aa)
	comt	Catechol-O-methyltransferase b. (264 aa)
	tyr	Tyrosinase. (540 aa)
	dct	Dopachrome tautomerase. (523 aa)
	ENSPFOP00000005741	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine). (145 aa)
	ENSPFOP00000005486	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (440 aa)
	ENSPFOP00000005418	Dual oxidase. (1639 aa)
	LOC103138597	Monooxygenase, DBH-like 1, like. (557 aa)
	ENSPFOP00000002726	COesterase domain-containing protein. (335 aa)
	PNMT	Phenylethanolamine N-methyltransferase. (241 aa)
	sncb	Beta-synuclein; Belongs to the synuclein family. (117 aa)
	med1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1793 aa)
	TYRP1	Tyrosinase related protein 1. (530 aa)
	ENSPFOP00000000496	Fumarylacetoacetase. (418 aa)
	ENSPFOP00000000489	Synuclein, alpha interacting protein. (766 aa)

Your Current Organism:

Poecilia formosa

NCBI taxonomy Id: 48698
Other names: Amazon molly, Limia formosa, Mollienesia formosa, P. formosa

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CPQ	ENSPFOP00000002726	ENSPFOP00000010513	ENSPFOP00000002726	Carboxypeptidase Q.	COesterase domain-containing protein.	0.499
DIO3	iyd	ENSPFOP00000015187	ENSPFOP00000011713	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine).	Iodotyrosine deiodinase.	0.608
ENSPFOP00000000489	ENSPFOP00000005486	ENSPFOP00000000489	ENSPFOP00000005486	Synuclein, alpha interacting protein.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.978
ENSPFOP00000000489	sncb	ENSPFOP00000000489	ENSPFOP00000001671	Synuclein, alpha interacting protein.	Beta-synuclein; Belongs to the synuclein family.	0.433
ENSPFOP00000002726	CPQ	ENSPFOP00000002726	ENSPFOP00000010513	COesterase domain-containing protein.	Carboxypeptidase Q.	0.499
ENSPFOP00000005486	ENSPFOP00000000489	ENSPFOP00000005486	ENSPFOP00000000489	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	Synuclein, alpha interacting protein.	0.978
ENSPFOP00000005486	ENSPFOP00000010642	ENSPFOP00000005486	ENSPFOP00000010642	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	Amine oxidase.	0.751
ENSPFOP00000005486	bcl2	ENSPFOP00000005486	ENSPFOP00000021079	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	BCL2 apoptosis regulator b.	0.729
ENSPFOP00000005486	maob	ENSPFOP00000005486	ENSPFOP00000009010	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	Amine oxidase.	0.751
ENSPFOP00000010642	ENSPFOP00000005486	ENSPFOP00000010642	ENSPFOP00000005486	Amine oxidase.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.751
ENSPFOP00000010642	ENSPFOP00000017782	ENSPFOP00000010642	ENSPFOP00000017782	Amine oxidase.	Histidine decarboxylase.	0.765
ENSPFOP00000010642	ENSPFOP00000018121	ENSPFOP00000010642	ENSPFOP00000018121	Amine oxidase.	Tyrosine hydroxylase 2.	0.595
ENSPFOP00000010642	ENSPFOP00000019817	ENSPFOP00000010642	ENSPFOP00000019817	Amine oxidase.	Dopamine beta-hydroxylase (dopamine beta-monooxygenase).	0.935
ENSPFOP00000010642	ENSPFOP00000030863	ENSPFOP00000010642	ENSPFOP00000030863	Amine oxidase.	Tryptophan hydroxylase 2 (tryptophan 5-monooxygenase).	0.535
ENSPFOP00000010642	LOC103138118	ENSPFOP00000010642	ENSPFOP00000012195	Amine oxidase.	D-dopachrome tautomerase.	0.505
ENSPFOP00000010642	LOC103138597	ENSPFOP00000010642	ENSPFOP00000004225	Amine oxidase.	Monooxygenase, DBH-like 1, like.	0.721
ENSPFOP00000010642	LOC103149204	ENSPFOP00000010642	ENSPFOP00000011433	Amine oxidase.	Uncharacterized protein.	0.535
ENSPFOP00000010642	LRTOMT	ENSPFOP00000010642	ENSPFOP00000008534	Amine oxidase.	Leucine rich transmembrane and O-methyltransferase domain containing.	0.828
ENSPFOP00000010642	PNMT	ENSPFOP00000010642	ENSPFOP00000001699	Amine oxidase.	Phenylethanolamine N-methyltransferase.	0.935
ENSPFOP00000010642	TPH1	ENSPFOP00000010642	ENSPFOP00000023585	Amine oxidase.	Tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) a.	0.535