(94 nodes) Polyol metabolic process network (Poecilia formosa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	ENSPFOP00000013969	Inositol polyphosphate-5-phosphatase B. (993 aa)
	gba	Glucosylceramidase. (522 aa)
	SGPP2	Sphingosine-1-phosphate phosphatase 2. (394 aa)
	plpp2	Phospholipid phosphatase 2a. (287 aa)
	tpi1	Triosephosphate isomerase. (247 aa)
	ISYNA1	Inositol-3-phosphate synthase 1. (555 aa)
	ENSPFOP00000014656	Diacylglycerol O-acyltransferase 2. (356 aa)
	LOC103131962	Serine palmitoyltransferase, long chain base subunit 1. (472 aa)
	ippk	Inositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). (496 aa)
	nudt3	Nudix (nucleoside diphosphate linked moiety X)-type motif 3b. (178 aa)
	plpp3	Phospholipid phosphatase 3. (313 aa)
	LOC103133683	Nudix (nucleoside diphosphate linked moiety X)-type motif 4a. (182 aa)
	LOC103134814	Si:dkey-91i10.3; Belongs to the cytochrome P450 family. (534 aa)
	LOC103144167	Kinase; Belongs to the inositol phosphokinase (IPK) family. (787 aa)
	inpp1	Si:ch211-160o17.2. (378 aa)
	LOC103129319	Nudix (nucleoside diphosphate linked moiety X)-type motif 4b. (186 aa)
	gk5	Glycerol kinase 5; Belongs to the FGGY kinase family. (525 aa)
	ENSPFOP00000017226	OCRL inositol polyphosphate-5-phosphatase. (666 aa)
	SPHK1-2	Sphingosine kinase 1. (422 aa)
	ENSPFOP00000017390	Galactokinase 1. (397 aa)
	ENSPFOP00000018237	Inositol polyphosphate-5-phosphatase Kb. (480 aa)
	LOC103154130	Si:ch211-113j14.1; Belongs to the cytochrome P450 family. (536 aa)
	bpnt1	Bisphosphate nucleotidase 1. (309 aa)
	ENSPFOP00000018682	Quinoid dihydropteridine reductase a. (257 aa)
	ENSPFOP00000018754	Sedoheptulokinase. (462 aa)
	LOC103142604	Phospholipid phosphatase 2b. (289 aa)
	miox	Myo-inositol oxygenase. (284 aa)
	pts	6-pyruvoyl tetrahydrobiopterin synthase. (147 aa)
	LOC103147557	Inositol-1-monophosphatase. (283 aa)
	impa1	Inositol-1-monophosphatase. (279 aa)
	COQ3	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. (335 aa)
	inpp5j	Inositol polyphosphate-5-phosphatase Ja. (774 aa)
	ENSPFOP00000020503	Uncharacterized protein. (176 aa)
	ENSPFOP00000022108	Dihydrofolate reductase. (127 aa)
	ENSPFOP00000022234	Sphingosine kinase 2. (644 aa)
	ENSPFOP00000022523	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (266 aa)
	ENSPFOP00000023477	Kinase; Belongs to the inositol phosphokinase (IPK) family. (523 aa)
	ENSPFOP00000029365	Synaptojanin 1. (1322 aa)
	ENSPFOP00000024388	Uncharacterized protein. (371 aa)
	ENSPFOP00000024571	Glycerol-3-phosphate dehydrogenase 2 (mitochondrial). (728 aa)
	LOC103141556	Uncharacterized protein. (504 aa)
	LOC103145785	Kinase; Belongs to the inositol phosphokinase (IPK) family. (506 aa)
	tkfc	Triokinase/FMN cyclase. (582 aa)
	ENSPFOP00000000539	Inositol-tetrakisphosphate 1-kinase; Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Belongs to the ITPK1 family. (327 aa)
	gk	Uncharacterized protein; Belongs to the FGGY kinase family. (557 aa)
	ENSPFOP00000000850	Uncharacterized protein; Belongs to the FGGY kinase family. (533 aa)
	pck1	Phosphoenolpyruvate carboxykinase 1 (soluble). (637 aa)
	acer3	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (267 aa)
	tmem130	PKD domain-containing protein. (308 aa)
	ENSPFOP00000002179	Methyl CpG binding protein 2. (540 aa)
	ENSPFOP00000002761	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (1405 aa)
	ENSPFOP00000003510	Phospholipid phosphatase 1a. (279 aa)
	ENSPFOP00000003852	Sorbitol dehydrogenase. (361 aa)
	impad1	Inositol monophosphatase domain containing 1. (344 aa)
	LOC103147313	Uncharacterized protein; Belongs to the acid ceramidase family. (356 aa)
	acer2	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (277 aa)
	ENSPFOP00000004610	Platelet-activating factor receptor; Belongs to the G-protein coupled receptor 1 family. (347 aa)
	LOC103143232	Kinase; Belongs to the inositol phosphokinase (IPK) family. (459 aa)
	ENSPFOP00000005056	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (1138 aa)
	ENSPFOP00000005116	Inositol polyphosphate-5-phosphatase E. (626 aa)
	PCBD2	Pterin-4 alpha-carbinolamine dehydratase 2. (136 aa)
	INPP5A	Inositol polyphosphate-5-phosphatase A. (350 aa)
	INPP5A-2	Inositol polyphosphate-5-phosphatase A. (225 aa)
	LOC103133057	Kinase; Belongs to the inositol phosphokinase (IPK) family. (459 aa)
	ENSPFOP00000006409	acidPPc domain-containing protein. (282 aa)
	LOC103138616	Si:ch211-212g7.6. (433 aa)
	itpka	Kinase; Belongs to the inositol phosphokinase (IPK) family. (452 aa)
	ENSPFOP00000006789	Neutral ceramidase. (737 aa)
	ENSPFOP00000006810	Cytochrome P450, family 2, subfamily R, polypeptide 1; Belongs to the cytochrome P450 family. (521 aa)
	ENSPFOP00000006883	Sepiapterin reductase b. (273 aa)
	ENSPFOP00000006959	N-acylsphingosine amidohydrolase (acid ceramidase) 1a; Belongs to the acid ceramidase family. (428 aa)
	COQ2	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. (374 aa)
	angptl3	Angiopoietin-like 3. (471 aa)
	pcbd1	Pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha. (102 aa)
	LOC103140010	Fibrinogen C-terminal domain-containing protein. (480 aa)
	gch1	GTP cyclohydrolase 1. (255 aa)
	ENSPFOP00000009258	Cytochrome P450, family 27, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (520 aa)
	ENSPFOP00000009322	Kinase; Belongs to the inositol phosphokinase (IPK) family. (275 aa)
	GOT1	Aspartate aminotransferase. (410 aa)
	LOC103145127	GTP cyclohydrolase 2. (236 aa)
	ENSPFOP00000009981	Triosephosphate isomerase. (248 aa)
	pck2	Phosphoenolpyruvate carboxykinase 2 (mitochondrial). (635 aa)
	SGPP1	acidPPc domain-containing protein. (453 aa)
	LOC103151855	Inositol polyphosphate-5-phosphatase Jb. (851 aa)
	ENSPFOP00000010979	Kinase; Belongs to the inositol phosphokinase (IPK) family. (415 aa)
	ENSPFOP00000011010	Kinase; Belongs to the inositol phosphokinase (IPK) family. (407 aa)
	LOC103129953	Inositol-1-monophosphatase. (295 aa)
	LOC103140044	acidPPc domain-containing protein. (307 aa)
	LOC103145212	Inositol polyphosphate-5-phosphatase Ka. (486 aa)
	LOC103133054	Neutral ceramidase-like. (737 aa)
	ENSPFOP00000012577	Aspartate aminotransferase. (413 aa)
	LOC103146094	Inositol polyphosphate-5-phosphatase L. (394 aa)
	SPHK1	Sphingosine kinase 1. (541 aa)
	LOC103138135	Uncharacterized protein; Belongs to the cytochrome P450 family. (509 aa)

Your Current Organism:

Poecilia formosa

NCBI taxonomy Id: 48698
Other names: Amazon molly, Limia formosa, Mollienesia formosa, P. formosa

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
COQ2	COQ3	ENSPFOP00000007904	ENSPFOP00000019517	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	0.929
COQ2	ENSPFOP00000003510	ENSPFOP00000007904	ENSPFOP00000003510	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	Phospholipid phosphatase 1a.	0.636
COQ2	ENSPFOP00000003852	ENSPFOP00000007904	ENSPFOP00000003852	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	Sorbitol dehydrogenase.	0.925
COQ2	ENSPFOP00000006409	ENSPFOP00000007904	ENSPFOP00000006409	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	acidPPc domain-containing protein.	0.636
COQ2	ENSPFOP00000006883	ENSPFOP00000007904	ENSPFOP00000006883	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	Sepiapterin reductase b.	0.480
COQ2	ENSPFOP00000009981	ENSPFOP00000007904	ENSPFOP00000009981	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	Triosephosphate isomerase.	0.513
COQ2	ENSPFOP00000018682	ENSPFOP00000007904	ENSPFOP00000018682	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	Quinoid dihydropteridine reductase a.	0.480
COQ2	LOC103129319	ENSPFOP00000007904	ENSPFOP00000016623	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	Nudix (nucleoside diphosphate linked moiety X)-type motif 4b.	0.550
COQ2	LOC103129953	ENSPFOP00000007904	ENSPFOP00000011753	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	Inositol-1-monophosphatase.	0.502
COQ2	LOC103133683	ENSPFOP00000007904	ENSPFOP00000016192	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	Nudix (nucleoside diphosphate linked moiety X)-type motif 4a.	0.550
COQ2	LOC103138616	ENSPFOP00000007904	ENSPFOP00000006574	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	Si:ch211-212g7.6.	0.636
COQ2	LOC103140044	ENSPFOP00000007904	ENSPFOP00000012276	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	acidPPc domain-containing protein.	0.636
COQ2	LOC103142604	ENSPFOP00000007904	ENSPFOP00000018785	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	Phospholipid phosphatase 2b.	0.636
COQ2	LOC103147557	ENSPFOP00000007904	ENSPFOP00000019503	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	Inositol-1-monophosphatase.	0.502
COQ2	SGPP1	ENSPFOP00000007904	ENSPFOP00000010307	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	acidPPc domain-containing protein.	0.636
COQ2	SGPP2	ENSPFOP00000007904	ENSPFOP00000014289	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	Sphingosine-1-phosphate phosphatase 2.	0.636
COQ2	impa1	ENSPFOP00000007904	ENSPFOP00000019505	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	Inositol-1-monophosphatase.	0.502
COQ2	nudt3	ENSPFOP00000007904	ENSPFOP00000015098	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	Nudix (nucleoside diphosphate linked moiety X)-type motif 3b.	0.550
COQ2	plpp2	ENSPFOP00000007904	ENSPFOP00000014453	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	Phospholipid phosphatase 2a.	0.636
COQ2	plpp3	ENSPFOP00000007904	ENSPFOP00000015594	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	Phospholipid phosphatase 3.	0.636