(20 nodes) Thyroid gland development network (Poecilia formosa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSPFOP00000011839	Paired box 5. (428 aa)
	ENSPFOP00000000651	NK2 homeobox 5. (313 aa)
	fgf8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	LOC103142284	Paired box 2b. (391 aa)
	LOC103148292	T-cell acute lymphocytic leukemia 1. (392 aa)
	edn1	Endothelin 1. (187 aa)
	ednra	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family. (444 aa)
	hand2	Heart and neural crest derivatives expressed 2. (245 aa)
	hhex	Homeobox domain-containing protein. (302 aa)
	ENSPFOP00000010234	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1250 aa)
	ENSPFOP00000010837	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (719 aa)
	pax2	Paired box 2a. (406 aa)
	LOC103155330	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1298 aa)
	ENSPFOP00000018268	Endothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family. (369 aa)
	ENSPFOP00000019074	Homeobox domain-containing protein. (177 aa)
	ENSPFOP00000019652	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1219 aa)
	pax8	Paired box 8. (462 aa)
	ENSPFOP00000026162	Serum response factor b. (601 aa)
	ENSPFOP00000026318	Paired domain-containing protein. (194 aa)
	ENSPFOP00000030391	MADS-box domain-containing protein. (378 aa)

Your Current Organism:

Poecilia formosa

NCBI taxonomy Id: 48698
Other names: Amazon molly, Limia formosa, Mollienesia formosa, P. formosa

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPFOP00000000651	ENSPFOP00000026162	ENSPFOP00000000651	ENSPFOP00000026162	NK2 homeobox 5.	Serum response factor b.	0.537
ENSPFOP00000000651	ENSPFOP00000030391	ENSPFOP00000000651	ENSPFOP00000030391	NK2 homeobox 5.	MADS-box domain-containing protein.	0.537
ENSPFOP00000000651	fgf8	ENSPFOP00000000651	ENSPFOP00000001274	NK2 homeobox 5.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.428
ENSPFOP00000000651	hand2	ENSPFOP00000000651	ENSPFOP00000009486	NK2 homeobox 5.	Heart and neural crest derivatives expressed 2.	0.757
ENSPFOP00000010234	ENSPFOP00000010837	ENSPFOP00000010234	ENSPFOP00000010837	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.866
ENSPFOP00000010234	ENSPFOP00000019652	ENSPFOP00000010234	ENSPFOP00000019652	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.867
ENSPFOP00000010234	LOC103155330	ENSPFOP00000010234	ENSPFOP00000016395	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.882
ENSPFOP00000010837	ENSPFOP00000010234	ENSPFOP00000010837	ENSPFOP00000010234	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.866
ENSPFOP00000010837	LOC103155330	ENSPFOP00000010837	ENSPFOP00000016395	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.623
ENSPFOP00000018268	edn1	ENSPFOP00000018268	ENSPFOP00000005291	Endothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family.	Endothelin 1.	0.993
ENSPFOP00000018268	ednra	ENSPFOP00000018268	ENSPFOP00000008961	Endothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family.	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family.	0.901
ENSPFOP00000019074	ENSPFOP00000026162	ENSPFOP00000019074	ENSPFOP00000026162	Homeobox domain-containing protein.	Serum response factor b.	0.616
ENSPFOP00000019074	ENSPFOP00000030391	ENSPFOP00000019074	ENSPFOP00000030391	Homeobox domain-containing protein.	MADS-box domain-containing protein.	0.616
ENSPFOP00000019652	ENSPFOP00000010234	ENSPFOP00000019652	ENSPFOP00000010234	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.867
ENSPFOP00000019652	LOC103155330	ENSPFOP00000019652	ENSPFOP00000016395	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.623
ENSPFOP00000026162	ENSPFOP00000000651	ENSPFOP00000026162	ENSPFOP00000000651	Serum response factor b.	NK2 homeobox 5.	0.537
ENSPFOP00000026162	ENSPFOP00000019074	ENSPFOP00000026162	ENSPFOP00000019074	Serum response factor b.	Homeobox domain-containing protein.	0.616
ENSPFOP00000026162	ENSPFOP00000030391	ENSPFOP00000026162	ENSPFOP00000030391	Serum response factor b.	MADS-box domain-containing protein.	0.902
ENSPFOP00000030391	ENSPFOP00000000651	ENSPFOP00000030391	ENSPFOP00000000651	MADS-box domain-containing protein.	NK2 homeobox 5.	0.537
ENSPFOP00000030391	ENSPFOP00000019074	ENSPFOP00000030391	ENSPFOP00000019074	MADS-box domain-containing protein.	Homeobox domain-containing protein.	0.616