(61 nodes) Pancreas development network (Poecilia formosa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103155894	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (111 aa)
	ENSPFOP00000030390	Wolfram syndrome 1a (wolframin). (663 aa)
	ENSPFOP00000019287	Fibroblast growth factor receptor. (813 aa)
	ENSPFOP00000019932	Regulatory factor X, 3 (influences HLA class II expression). (761 aa)
	LOC103151621	Achaete-scute family bHLH transcription factor 1b. (200 aa)
	ENSPFOP00000022644	Paired domain-containing protein. (140 aa)
	ENSPFOP00000001000	Eukaryotic translation initiation factor 2-alpha kinase 3. (1104 aa)
	ENSPFOP00000001489	Fat storage inducing transmembrane protein 2. (257 aa)
	LOC103141748	Hcy-binding domain-containing protein; Involved in the regulation of homocysteine metabolism. (397 aa)
	ENSPFOP00000002069	Insulinoma-associated 1b. (447 aa)
	pax4	Paired box 4. (390 aa)
	ptf1a	Pancreas associated transcription factor 1a. (267 aa)
	LOC103142354	T-box transcription factor Ta. (421 aa)
	ENSPFOP00000002566	Yes-associated protein 1. (445 aa)
	nkx6-1	NK6 homeobox 1. (328 aa)
	ENSPFOP00000002887	ISL LIM homeobox 2a. (346 aa)
	LOC103136030	NK2 homeobox 2a. (281 aa)
	ENSPFOP00000003122	Notch receptor 1a. (2477 aa)
	bmp2	Bone morphogenetic protein 2b. (419 aa)
	ENSPFOP00000003397	Regulatory factor X, 6. (709 aa)
	LOC103153227	Histone domain-containing protein. (152 aa)
	arx	Aristaless related homeobox a. (469 aa)
	ENSPFOP00000003889	Neuron navigator 3. (2329 aa)
	smo	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (811 aa)
	LOC103141969	Notch receptor 1b. (2491 aa)
	LOC103148151	NK6 homeobox 2. (281 aa)
	LOC103148157	Homeobox protein Nkx-6.2-like. (281 aa)
	ENSPFOP00000006743	Homeobox domain-containing protein. (307 aa)
	wfs1	Wolfram syndrome 1b (wolframin). (971 aa)
	LOC103135835	Betaine-homocysteine methyltransferase; Involved in the regulation of homocysteine metabolism. (397 aa)
	LOC103149657	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (378 aa)
	ENSPFOP00000007590	Pancreatic and duodenal homeobox 1. (252 aa)
	LOC103146512	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	LOC103150954	Zgc:153993. (204 aa)
	srp54	Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (504 aa)
	LOC103142390	Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. (489 aa)
	ENSPFOP00000009309	Uncharacterized protein. (200 aa)
	hnf1b	HNF1 homeobox Ba. (565 aa)
	hhex	Homeobox domain-containing protein. (302 aa)
	rnpc3	RNA-binding region (RNP1, RRM) containing 3. (507 aa)
	LOC103141950	ISL LIM homeobox 1. (360 aa)
	sart3	Spliceosome associated factor 3, U4/U6 recycling protein. (945 aa)
	pcsk1	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (766 aa)
	IKZF5	IKAROS family zinc finger 5. (410 aa)
	utp25	UTP25 small subunit processor component. (748 aa)
	hnf1a	HNF1 homeobox a. (562 aa)
	LOC103144431	Insulin-like growth factor 2b. (220 aa)
	ENSPFOP00000014652	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1503 aa)
	neurod1	Neurogenic differentiation factor. (352 aa)
	LOC103140457	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
	LOC103140819	Interleukin 6 receptor. (597 aa)
	mnx1	Motor neuron and pancreas homeobox 1. (320 aa)
	cdkal1	CDK5 regulatory subunit associated protein 1-like 1. (563 aa)
	ISL2	ISL LIM homeobox 2b. (360 aa)
	suv39h1	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (421 aa)
	pax6	Paired box 6b. (449 aa)
	EIF2AK3	Eukaryotic translation initiation factor 2 alpha kinase 3. (951 aa)
	MYO1D	Myosin ID; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1014 aa)
	ENSPFOP00000023625	Peptidase_S8 domain-containing protein. (131 aa)
	LOC103133578	IKAROS family zinc finger 5. (424 aa)
	LOC103130811	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (117 aa)

Your Current Organism:

Poecilia formosa

NCBI taxonomy Id: 48698
Other names: Amazon molly, Limia formosa, Mollienesia formosa, P. formosa

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPFOP00000002069	neurod1	ENSPFOP00000002069	ENSPFOP00000014998	Insulinoma-associated 1b.	Neurogenic differentiation factor.	0.565
ENSPFOP00000002566	ENSPFOP00000003122	ENSPFOP00000002566	ENSPFOP00000003122	Yes-associated protein 1.	Notch receptor 1a.	0.401
ENSPFOP00000002566	LOC103141969	ENSPFOP00000002566	ENSPFOP00000004846	Yes-associated protein 1.	Notch receptor 1b.	0.401
ENSPFOP00000002566	srp54	ENSPFOP00000002566	ENSPFOP00000008897	Yes-associated protein 1.	Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily.	0.498
ENSPFOP00000002887	LOC103151621	ENSPFOP00000002887	ENSPFOP00000020757	ISL LIM homeobox 2a.	Achaete-scute family bHLH transcription factor 1b.	0.519
ENSPFOP00000002887	mnx1	ENSPFOP00000002887	ENSPFOP00000015863	ISL LIM homeobox 2a.	Motor neuron and pancreas homeobox 1.	0.429
ENSPFOP00000002887	ptf1a	ENSPFOP00000002887	ENSPFOP00000002350	ISL LIM homeobox 2a.	Pancreas associated transcription factor 1a.	0.535
ENSPFOP00000003122	ENSPFOP00000002566	ENSPFOP00000003122	ENSPFOP00000002566	Notch receptor 1a.	Yes-associated protein 1.	0.401
ENSPFOP00000003122	ENSPFOP00000003889	ENSPFOP00000003122	ENSPFOP00000003889	Notch receptor 1a.	Neuron navigator 3.	0.415
ENSPFOP00000003122	ENSPFOP00000009309	ENSPFOP00000003122	ENSPFOP00000009309	Notch receptor 1a.	Uncharacterized protein.	0.401
ENSPFOP00000003122	LOC103140457	ENSPFOP00000003122	ENSPFOP00000015525	Notch receptor 1a.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.420
ENSPFOP00000003397	LOC103130811	ENSPFOP00000003397	ENSPFOP00000017892	Regulatory factor X, 6.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.591
ENSPFOP00000003397	LOC103136030	ENSPFOP00000003397	ENSPFOP00000003052	Regulatory factor X, 6.	NK2 homeobox 2a.	0.416
ENSPFOP00000003397	LOC103155894	ENSPFOP00000003397	ENSPFOP00000026919	Regulatory factor X, 6.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.591
ENSPFOP00000003397	mnx1	ENSPFOP00000003397	ENSPFOP00000015863	Regulatory factor X, 6.	Motor neuron and pancreas homeobox 1.	0.554
ENSPFOP00000003397	neurod1	ENSPFOP00000003397	ENSPFOP00000014998	Regulatory factor X, 6.	Neurogenic differentiation factor.	0.447
ENSPFOP00000003397	ptf1a	ENSPFOP00000003397	ENSPFOP00000002350	Regulatory factor X, 6.	Pancreas associated transcription factor 1a.	0.422
ENSPFOP00000003889	ENSPFOP00000003122	ENSPFOP00000003889	ENSPFOP00000003122	Neuron navigator 3.	Notch receptor 1a.	0.415
ENSPFOP00000003889	LOC103141969	ENSPFOP00000003889	ENSPFOP00000004846	Neuron navigator 3.	Notch receptor 1b.	0.415
ENSPFOP00000006743	ENSPFOP00000007590	ENSPFOP00000006743	ENSPFOP00000007590	Homeobox domain-containing protein.	Pancreatic and duodenal homeobox 1.	0.569