(22 nodes) Late endosome to vacuole transport via multivesicular body sorting pathway network (Poecilia formosa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103149800	Charged multivesicular body protein 5b. (219 aa)
	LOC103140929	Charged multivesicular body protein 6a. (207 aa)
	ENSPFOP00000006627	Charged multivesicular body protein 4Bb. (228 aa)
	LEPROT	Leptin receptor overlapping transcript. (130 aa)
	stam	Signal transducing adaptor molecule (SH3 domain and ITAM motif) 1. (512 aa)
	ENSPFOP00000030685	Charged multivesicular body protein 7. (267 aa)
	LOC103147035	Charged multivesicular body protein 6-like. (207 aa)
	LOC103156962	Uncharacterized protein. (223 aa)
	vps25	Vacuolar protein sorting 25 homolog. (174 aa)
	tmem50a	Transmembrane protein 50A. (160 aa)
	LOC103148399	Charged multivesicular body protein 7. (451 aa)
	LOC103152176	Leptin receptor overlapping transcript like 1. (131 aa)
	TMEM50B	Transmembrane protein 50B. (159 aa)
	ptpn23	Protein tyrosine phosphatase, non-receptor type 23, a. (1881 aa)
	vps28	Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. (223 aa)
	ENSPFOP00000000773	Charged multivesicular body protein 6. (207 aa)
	LOC103152176-2	Leptin receptor overlapping transcript-like 1. (131 aa)
	chmp5	Charged multivesicular body protein 5a. (220 aa)
	snf8	Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (258 aa)
	vps36	Vacuolar protein sorting 36 homolog. (382 aa)
	ENSPFOP00000016613	Charged multivesicular body protein 4C. (235 aa)
	ENSPFOP00000015029	Vesicle (multivesicular body) trafficking 1. (309 aa)

Your Current Organism:

Poecilia formosa

NCBI taxonomy Id: 48698
Other names: Amazon molly, Limia formosa, Mollienesia formosa, P. formosa

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPFOP00000000773	ENSPFOP00000006627	ENSPFOP00000000773	ENSPFOP00000006627	Charged multivesicular body protein 6.	Charged multivesicular body protein 4Bb.	0.897
ENSPFOP00000000773	ENSPFOP00000015029	ENSPFOP00000000773	ENSPFOP00000015029	Charged multivesicular body protein 6.	Vesicle (multivesicular body) trafficking 1.	0.754
ENSPFOP00000000773	ENSPFOP00000016613	ENSPFOP00000000773	ENSPFOP00000016613	Charged multivesicular body protein 6.	Charged multivesicular body protein 4C.	0.900
ENSPFOP00000000773	ENSPFOP00000030685	ENSPFOP00000000773	ENSPFOP00000030685	Charged multivesicular body protein 6.	Charged multivesicular body protein 7.	0.755
ENSPFOP00000000773	LOC103140929	ENSPFOP00000000773	ENSPFOP00000006031	Charged multivesicular body protein 6.	Charged multivesicular body protein 6a.	0.894
ENSPFOP00000000773	LOC103148399	ENSPFOP00000000773	ENSPFOP00000030130	Charged multivesicular body protein 6.	Charged multivesicular body protein 7.	0.755
ENSPFOP00000000773	LOC103149800	ENSPFOP00000000773	ENSPFOP00000014086	Charged multivesicular body protein 6.	Charged multivesicular body protein 5b.	0.804
ENSPFOP00000000773	LOC103156962	ENSPFOP00000000773	ENSPFOP00000019231	Charged multivesicular body protein 6.	Uncharacterized protein.	0.897
ENSPFOP00000000773	chmp5	ENSPFOP00000000773	ENSPFOP00000004627	Charged multivesicular body protein 6.	Charged multivesicular body protein 5a.	0.804
ENSPFOP00000000773	ptpn23	ENSPFOP00000000773	ENSPFOP00000013659	Charged multivesicular body protein 6.	Protein tyrosine phosphatase, non-receptor type 23, a.	0.403
ENSPFOP00000000773	snf8	ENSPFOP00000000773	ENSPFOP00000018301	Charged multivesicular body protein 6.	Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family.	0.961
ENSPFOP00000000773	vps25	ENSPFOP00000000773	ENSPFOP00000022470	Charged multivesicular body protein 6.	Vacuolar protein sorting 25 homolog.	0.964
ENSPFOP00000000773	vps28	ENSPFOP00000000773	ENSPFOP00000012891	Charged multivesicular body protein 6.	Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.	0.895
ENSPFOP00000000773	vps36	ENSPFOP00000000773	ENSPFOP00000017934	Charged multivesicular body protein 6.	Vacuolar protein sorting 36 homolog.	0.952
ENSPFOP00000006627	ENSPFOP00000000773	ENSPFOP00000006627	ENSPFOP00000000773	Charged multivesicular body protein 4Bb.	Charged multivesicular body protein 6.	0.897
ENSPFOP00000006627	ENSPFOP00000015029	ENSPFOP00000006627	ENSPFOP00000015029	Charged multivesicular body protein 4Bb.	Vesicle (multivesicular body) trafficking 1.	0.887
ENSPFOP00000006627	ENSPFOP00000016613	ENSPFOP00000006627	ENSPFOP00000016613	Charged multivesicular body protein 4Bb.	Charged multivesicular body protein 4C.	0.923
ENSPFOP00000006627	ENSPFOP00000030685	ENSPFOP00000006627	ENSPFOP00000030685	Charged multivesicular body protein 4Bb.	Charged multivesicular body protein 7.	0.959
ENSPFOP00000006627	LOC103140929	ENSPFOP00000006627	ENSPFOP00000006031	Charged multivesicular body protein 4Bb.	Charged multivesicular body protein 6a.	0.900
ENSPFOP00000006627	LOC103147035	ENSPFOP00000006627	ENSPFOP00000018896	Charged multivesicular body protein 4Bb.	Charged multivesicular body protein 6-like.	0.897