(40 nodes) Cellular response to amino acid starvation network (Poecilia formosa)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	wdr24	WD repeat domain 24. (783 aa)
	LOC103154974	Uncharacterized protein. (381 aa)
	ENSPFOP00000001000	Eukaryotic translation initiation factor 2-alpha kinase 3. (1104 aa)
	wdr59	WD repeat domain 59. (958 aa)
	rragc	Ras-related GTP binding Ca. (382 aa)
	lars1	Leucyl-tRNA synthetase b; Belongs to the class-I aminoacyl-tRNA synthetase family. (1184 aa)
	LOC103154846	Activating transcription factor 4a. (424 aa)
	ENSPFOP00000006137	Missing oocyte, meiosis regulator, homolog (Drosophila). (879 aa)
	LOC103135050	Sestrin 2. (558 aa)
	ENSPFOP00000007914	Si:ch211-153j24.3. (357 aa)
	gcn1	GCN1 activator of EIF2AK4. (2690 aa)
	mtor	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2516 aa)
	ENSPFOP00000008723	Si:zfos-80g12.1. (431 aa)
	dap	Death-associated protein. (105 aa)
	flcn	Folliculin. (554 aa)
	nprl3	NPR3-like, GATOR1 complex subunit. (596 aa)
	EIF2AK4	Eukaryotic translation initiation factor 2 alpha kinase 4. (1652 aa)
	SZT2	SZT2 subunit of KICSTOR complex. (3615 aa)
	bmt2	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (387 aa)
	ENSPFOP00000014268	DEP domain containing 5. (1578 aa)
	LOC103133531	Uncharacterized protein. (327 aa)
	ENSPFOP00000017071	Si:ch211-125a15.1. (452 aa)
	atf3	Activating transcription factor 3. (259 aa)
	EIF2AK3	Eukaryotic translation initiation factor 2 alpha kinase 3. (951 aa)
	dapl1	Death associated protein 1b. (116 aa)
	kptn	Kaptin (actin binding protein). (443 aa)
	itfg2	Integrin alpha FG-GAP repeat containing 2. (433 aa)
	eif2s1	Eukaryotic translation initiation factor 2, subunit 1 alpha b. (382 aa)
	ENSPFOP00000019561	Uncharacterized protein. (661 aa)
	ENSPFOP00000019569	Eukaryotic translation initiation factor 2-alpha kinase 2. (700 aa)
	ENSPFOP00000019575	Ras-related GTP binding A. (319 aa)
	sesn1	Sestrin 1. (488 aa)
	ENSPFOP00000021100	Ring finger protein 152. (211 aa)
	RNF152	Ring finger protein 152. (211 aa)
	ENSPFOP00000023484	Protein kinase domain-containing protein. (564 aa)
	seh1l	SEH1-like (S. cerevisiae); Belongs to the WD repeat SEC13 family. (383 aa)
	nprl2	NPR2 like, GATOR1 complex subunit. (381 aa)
	ENSPFOP00000027454	CBM21 domain-containing protein. (259 aa)
	impact	Impact RWD domain protein. (320 aa)
	tfeb	Transcription factor EB. (514 aa)

Your Current Organism:

Poecilia formosa

NCBI taxonomy Id: 48698
Other names: Amazon molly, Limia formosa, Mollienesia formosa, P. formosa

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EIF2AK3	EIF2AK4	ENSPFOP00000017268	ENSPFOP00000010986	Eukaryotic translation initiation factor 2 alpha kinase 3.	Eukaryotic translation initiation factor 2 alpha kinase 4.	0.922
EIF2AK3	ENSPFOP00000007914	ENSPFOP00000017268	ENSPFOP00000007914	Eukaryotic translation initiation factor 2 alpha kinase 3.	Si:ch211-153j24.3.	0.539
EIF2AK3	ENSPFOP00000019561	ENSPFOP00000017268	ENSPFOP00000019561	Eukaryotic translation initiation factor 2 alpha kinase 3.	Uncharacterized protein.	0.595
EIF2AK3	ENSPFOP00000019569	ENSPFOP00000017268	ENSPFOP00000019569	Eukaryotic translation initiation factor 2 alpha kinase 3.	Eukaryotic translation initiation factor 2-alpha kinase 2.	0.824
EIF2AK3	ENSPFOP00000023484	ENSPFOP00000017268	ENSPFOP00000023484	Eukaryotic translation initiation factor 2 alpha kinase 3.	Protein kinase domain-containing protein.	0.595
EIF2AK3	LOC103154846	ENSPFOP00000017268	ENSPFOP00000005968	Eukaryotic translation initiation factor 2 alpha kinase 3.	Activating transcription factor 4a.	0.936
EIF2AK3	atf3	ENSPFOP00000017268	ENSPFOP00000017167	Eukaryotic translation initiation factor 2 alpha kinase 3.	Activating transcription factor 3.	0.554
EIF2AK3	eif2s1	ENSPFOP00000017268	ENSPFOP00000018891	Eukaryotic translation initiation factor 2 alpha kinase 3.	Eukaryotic translation initiation factor 2, subunit 1 alpha b.	0.980
EIF2AK4	EIF2AK3	ENSPFOP00000010986	ENSPFOP00000017268	Eukaryotic translation initiation factor 2 alpha kinase 4.	Eukaryotic translation initiation factor 2 alpha kinase 3.	0.922
EIF2AK4	ENSPFOP00000001000	ENSPFOP00000010986	ENSPFOP00000001000	Eukaryotic translation initiation factor 2 alpha kinase 4.	Eukaryotic translation initiation factor 2-alpha kinase 3.	0.922
EIF2AK4	ENSPFOP00000019561	ENSPFOP00000010986	ENSPFOP00000019561	Eukaryotic translation initiation factor 2 alpha kinase 4.	Uncharacterized protein.	0.697
EIF2AK4	ENSPFOP00000019569	ENSPFOP00000010986	ENSPFOP00000019569	Eukaryotic translation initiation factor 2 alpha kinase 4.	Eukaryotic translation initiation factor 2-alpha kinase 2.	0.697
EIF2AK4	ENSPFOP00000019575	ENSPFOP00000010986	ENSPFOP00000019575	Eukaryotic translation initiation factor 2 alpha kinase 4.	Ras-related GTP binding A.	0.522
EIF2AK4	ENSPFOP00000023484	ENSPFOP00000010986	ENSPFOP00000023484	Eukaryotic translation initiation factor 2 alpha kinase 4.	Protein kinase domain-containing protein.	0.697
EIF2AK4	LOC103154846	ENSPFOP00000010986	ENSPFOP00000005968	Eukaryotic translation initiation factor 2 alpha kinase 4.	Activating transcription factor 4a.	0.585
EIF2AK4	eif2s1	ENSPFOP00000010986	ENSPFOP00000018891	Eukaryotic translation initiation factor 2 alpha kinase 4.	Eukaryotic translation initiation factor 2, subunit 1 alpha b.	0.996
EIF2AK4	gcn1	ENSPFOP00000010986	ENSPFOP00000008022	Eukaryotic translation initiation factor 2 alpha kinase 4.	GCN1 activator of EIF2AK4.	0.886
EIF2AK4	impact	ENSPFOP00000010986	ENSPFOP00000029309	Eukaryotic translation initiation factor 2 alpha kinase 4.	Impact RWD domain protein.	0.565
EIF2AK4	lars1	ENSPFOP00000010986	ENSPFOP00000002939	Eukaryotic translation initiation factor 2 alpha kinase 4.	Leucyl-tRNA synthetase b; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.686
EIF2AK4	mtor	ENSPFOP00000010986	ENSPFOP00000008461	Eukaryotic translation initiation factor 2 alpha kinase 4.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.914