(47 nodes) Cellular response to glucose starvation network (Poecilia formosa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EIF2AK3	Eukaryotic translation initiation factor 2 alpha kinase 3. (951 aa)
	LOC103135050	Sestrin 2. (558 aa)
	ENSPFOP00000006753	Phosphatidylinositol 3-kinase, catalytic subunit type 3; Belongs to the PI3/PI4-kinase family. (605 aa)
	sik2	Salt-inducible kinase 2b. (933 aa)
	LOC103143028	Protein kinase, AMP-activated, gamma 2 non-catalytic subunit b. (544 aa)
	pik3r4	Phosphoinositide-3-kinase, regulatory subunit 4. (1325 aa)
	LOC103138456	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (448 aa)
	LOC103132862	Si:dkey-206d17.12. (370 aa)
	LOC103130708	Si:ch211-22d5.2; Belongs to the protein kinase superfamily. (387 aa)
	LOC103156828	Protein kinase domain-containing protein. (753 aa)
	ENSPFOP00000002213	Protein kinase domain-containing protein. (738 aa)
	LOC103129126	WD_REPEATS_REGION domain-containing protein. (441 aa)
	ENSPFOP00000001404	Transducin (beta)-like 2. (369 aa)
	atg14	Autophagy related 14. (506 aa)
	ENSPFOP00000001021	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (427 aa)
	ENSPFOP00000001000	Eukaryotic translation initiation factor 2-alpha kinase 3. (1104 aa)
	LOC103144506	Cytoplasmic polyadenylation element binding protein 4a. (741 aa)
	nuak2	NUAK family, SNF1-like kinase, 2. (606 aa)
	impact	Impact RWD domain protein. (320 aa)
	ENSPFOP00000026083	Phosphatidylinositol 3-kinase, catalytic subunit type 3; Belongs to the PI3/PI4-kinase family. (271 aa)
	prkag1	Protein kinase, AMP-activated, gamma 1 non-catalytic subunit. (334 aa)
	ENSPFOP00000021113	Protein kinase, AMP-activated, gamma 3a non-catalytic subunit. (183 aa)
	bcl2	BCL2 apoptosis regulator b. (229 aa)
	hspa5	Heat shock protein 5; Belongs to the heat shock protein 70 family. (652 aa)
	sesn1	Sestrin 1. (488 aa)
	LOC103149938	Protein kinase, AMP-activated, gamma 3b non-catalytic subunit. (401 aa)
	BRSK2	BR serine/threonine kinase 2. (829 aa)
	itfg2	Integrin alpha FG-GAP repeat containing 2. (433 aa)
	kptn	Kaptin (actin binding protein). (443 aa)
	ENSPFOP00000017071	Si:ch211-125a15.1. (452 aa)
	prkaa2	Non-specific serine/threonine protein kinase. (557 aa)
	prkaa1	Non-specific serine/threonine protein kinase. (564 aa)
	ENSPFOP00000014582	X-box binding protein 1. (387 aa)
	nfe2l2	Nuclear factor, erythroid 2-like 2a. (617 aa)
	LOC103149215	Si:dkey-16p21.7. (866 aa)
	zc3h12a	Zinc finger CCCH-type containing 12A. (627 aa)
	LOC103140296	Salt-inducible kinase 1. (806 aa)
	SZT2	SZT2 subunit of KICSTOR complex. (3615 aa)
	bhlha15	Basic helix-loop-helix family, member a15. (248 aa)
	pick1	Protein interacting with prkca 1. (409 aa)
	PRKAG2	Protein kinase AMP-activated non-catalytic subunit gamma 2. (494 aa)
	sirt1	Sirtuin 1. (677 aa)
	LOC103141875	Si:ch211-117c9.1. (702 aa)
	nuak1	NUAK family, SNF1-like kinase, 1b. (661 aa)
	ENSPFOP00000008723	Si:zfos-80g12.1. (431 aa)
	nim1k	NIM1 serine/threonine protein kinase; Belongs to the protein kinase superfamily. (475 aa)
	rrp8	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family. (548 aa)

Your Current Organism:

Poecilia formosa

NCBI taxonomy Id: 48698
Other names: Amazon molly, Limia formosa, Mollienesia formosa, P. formosa

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EIF2AK3	ENSPFOP00000014582	ENSPFOP00000017268	ENSPFOP00000014582	Eukaryotic translation initiation factor 2 alpha kinase 3.	X-box binding protein 1.	0.523
EIF2AK3	hspa5	ENSPFOP00000017268	ENSPFOP00000019977	Eukaryotic translation initiation factor 2 alpha kinase 3.	Heat shock protein 5; Belongs to the heat shock protein 70 family.	0.942
EIF2AK3	nfe2l2	ENSPFOP00000017268	ENSPFOP00000014116	Eukaryotic translation initiation factor 2 alpha kinase 3.	Nuclear factor, erythroid 2-like 2a.	0.931
ENSPFOP00000001000	ENSPFOP00000014582	ENSPFOP00000001000	ENSPFOP00000014582	Eukaryotic translation initiation factor 2-alpha kinase 3.	X-box binding protein 1.	0.523
ENSPFOP00000001000	hspa5	ENSPFOP00000001000	ENSPFOP00000019977	Eukaryotic translation initiation factor 2-alpha kinase 3.	Heat shock protein 5; Belongs to the heat shock protein 70 family.	0.942
ENSPFOP00000001000	nfe2l2	ENSPFOP00000001000	ENSPFOP00000014116	Eukaryotic translation initiation factor 2-alpha kinase 3.	Nuclear factor, erythroid 2-like 2a.	0.931
ENSPFOP00000001021	ENSPFOP00000006753	ENSPFOP00000001021	ENSPFOP00000006753	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Phosphatidylinositol 3-kinase, catalytic subunit type 3; Belongs to the PI3/PI4-kinase family.	0.446
ENSPFOP00000001021	ENSPFOP00000021113	ENSPFOP00000001021	ENSPFOP00000021113	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Protein kinase, AMP-activated, gamma 3a non-catalytic subunit.	0.704
ENSPFOP00000001021	ENSPFOP00000026083	ENSPFOP00000001021	ENSPFOP00000026083	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Phosphatidylinositol 3-kinase, catalytic subunit type 3; Belongs to the PI3/PI4-kinase family.	0.446
ENSPFOP00000001021	LOC103141875	ENSPFOP00000001021	ENSPFOP00000009101	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Si:ch211-117c9.1.	0.463
ENSPFOP00000001021	LOC103143028	ENSPFOP00000001021	ENSPFOP00000005360	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Protein kinase, AMP-activated, gamma 2 non-catalytic subunit b.	0.704
ENSPFOP00000001021	LOC103149938	ENSPFOP00000001021	ENSPFOP00000018700	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Protein kinase, AMP-activated, gamma 3b non-catalytic subunit.	0.704
ENSPFOP00000001021	PRKAG2	ENSPFOP00000001021	ENSPFOP00000010982	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Protein kinase AMP-activated non-catalytic subunit gamma 2.	0.704
ENSPFOP00000001021	nuak1	ENSPFOP00000001021	ENSPFOP00000008747	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	NUAK family, SNF1-like kinase, 1b.	0.451
ENSPFOP00000001021	nuak2	ENSPFOP00000001021	ENSPFOP00000000344	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	NUAK family, SNF1-like kinase, 2.	0.467
ENSPFOP00000001021	pik3r4	ENSPFOP00000001021	ENSPFOP00000004934	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Phosphoinositide-3-kinase, regulatory subunit 4.	0.556
ENSPFOP00000001021	prkag1	ENSPFOP00000001021	ENSPFOP00000025928	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Protein kinase, AMP-activated, gamma 1 non-catalytic subunit.	0.704
ENSPFOP00000006753	ENSPFOP00000001021	ENSPFOP00000006753	ENSPFOP00000001021	Phosphatidylinositol 3-kinase, catalytic subunit type 3; Belongs to the PI3/PI4-kinase family.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.446
ENSPFOP00000006753	ENSPFOP00000021113	ENSPFOP00000006753	ENSPFOP00000021113	Phosphatidylinositol 3-kinase, catalytic subunit type 3; Belongs to the PI3/PI4-kinase family.	Protein kinase, AMP-activated, gamma 3a non-catalytic subunit.	0.642
ENSPFOP00000006753	ENSPFOP00000026083	ENSPFOP00000006753	ENSPFOP00000026083	Phosphatidylinositol 3-kinase, catalytic subunit type 3; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 3-kinase, catalytic subunit type 3; Belongs to the PI3/PI4-kinase family.	0.899