(62 nodes) Positive regulation of MAP kinase activity network (Poecilia formosa)

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second shell of interactors

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proteins of unknown 3D structure

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Predicted Interactions

gene neighborhood

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Your Input:
	map3k13	Mitogen-activated protein kinase kinase kinase. (1008 aa)
	LOC103129920	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (210 aa)
	ENSPFOP00000000757	Uncharacterized protein. (528 aa)
	ENSPFOP00000000962	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
	ENSPFOP00000001361	Dopamine receptor D4a; Belongs to the G-protein coupled receptor 1 family. (372 aa)
	pik3r5	Phosphoinositide-3-kinase, regulatory subunit 5. (879 aa)
	tnfsf11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (268 aa)
	LOC103154828	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (199 aa)
	ENSPFOP00000004812	NIMA-related kinase 10. (825 aa)
	edn1	Endothelin 1. (187 aa)
	ENSPFOP00000005800	Teneurin transmembrane protein 1. (2585 aa)
	PIK3R5	Phosphoinositide-3-kinase regulatory subunit 5. (826 aa)
	ENSPFOP00000005958	Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. (454 aa)
	LOC103151897	Dual specificity phosphatase 19. (203 aa)
	ENSPFOP00000006511	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (152 aa)
	LOC103150965	CD40 molecule, TNF receptor superfamily member 5. (313 aa)
	fzd4	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (531 aa)
	map2k5	Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (444 aa)
	LOC103130409	Uncharacterized protein. (874 aa)
	map2k7	Mitogen-activated protein kinase kinase 7. (439 aa)
	LOC103154418	Interleukin-1. (247 aa)
	ENSPFOP00000007617	FAD-binding FR-type domain-containing protein. (561 aa)
	ern1	Endoplasmic reticulum to nucleus signaling 1. (1060 aa)
	p2rx7	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (577 aa)
	tnfrsf11a	Tumor necrosis factor receptor superfamily, member 11a, NFKB activator. (658 aa)
	LOC103145984	Ajuba LIM protein. (658 aa)
	LOC103138778	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (491 aa)
	ENSPFOP00000009709	SCY domain-containing protein. (112 aa)
	ENSPFOP00000010413	Tpd52 like 1. (201 aa)
	ENSPFOP00000010428	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (159 aa)
	ENSPFOP00000010700	Dual specificity phosphatase 19a. (202 aa)
	ENSPFOP00000011063	Protein tyrosine phosphatase receptor type C. (1210 aa)
	ENSPFOP00000011880	Leucine-rich repeat kinase 2. (1882 aa)
	LOC103142045	EGF-like domain-containing protein. (178 aa)
	axin1	Axin 1. (850 aa)
	pdgfa	Platelet-derived growth factor alpha polypeptide b; Belongs to the PDGF/VEGF growth factor family. (208 aa)
	pik3cg	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1121 aa)
	LOC103136433	Uncharacterized protein. (883 aa)
	ntf3	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (304 aa)
	map3k7	Mitogen-activated protein kinase kinase kinase 7. (600 aa)
	LOC103129965	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (406 aa)
	map3k4	Mitogen-activated protein kinase kinase kinase 4. (1573 aa)
	pdcd10	Programmed cell death 10b. (210 aa)
	ENSPFOP00000015250	SAM and SH3 domain containing 1b. (1060 aa)
	il34	Interleukin 34. (225 aa)
	ENSPFOP00000015559	Dickkopf WNT signaling pathway inhibitor 1a. (244 aa)
	LOC103138264	Transforming growth factor beta; Belongs to the TGF-beta family. (380 aa)
	LOC103148401	Fibroblast growth factor receptor. (831 aa)
	ENSPFOP00000018418	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (158 aa)
	LOC103137301	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
	pdgfc	Platelet derived growth factor c; Belongs to the PDGF/VEGF growth factor family. (361 aa)
	ENSPFOP00000019567	Si:rp71-17i16.5; Belongs to the PI3/PI4-kinase family. (754 aa)
	ENSPFOP00000019732	SAM and SH3 domain containing 1a. (1223 aa)
	ENSPFOP00000020084	Frizzled class receptor 8a; Belongs to the G-protein coupled receptor Fz/Smo family. (594 aa)
	ENSPFOP00000020094	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (588 aa)
	ENSPFOP00000020099	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (704 aa)
	htr2b	5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled. (466 aa)
	ENSPFOP00000023305	Protein kinase domain-containing protein. (225 aa)
	vegfa	Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family. (214 aa)
	ENSPFOP00000029851	Uncharacterized protein. (362 aa)
	tgfa	Transforming growth factor, alpha. (248 aa)

Your Current Organism:

Poecilia formosa

NCBI taxonomy Id: 48698
Other names: Amazon molly, Limia formosa, Mollienesia formosa, P. formosa

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPFOP00000000757	map2k5	ENSPFOP00000000757	ENSPFOP00000006686	Uncharacterized protein.	Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily.	0.484
ENSPFOP00000000757	map2k7	ENSPFOP00000000757	ENSPFOP00000007380	Uncharacterized protein.	Mitogen-activated protein kinase kinase 7.	0.539
ENSPFOP00000000962	ENSPFOP00000011063	ENSPFOP00000000962	ENSPFOP00000011063	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Protein tyrosine phosphatase receptor type C.	0.412
ENSPFOP00000000962	ENSPFOP00000015250	ENSPFOP00000000962	ENSPFOP00000015250	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	SAM and SH3 domain containing 1b.	0.455
ENSPFOP00000000962	ENSPFOP00000019732	ENSPFOP00000000962	ENSPFOP00000019732	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	SAM and SH3 domain containing 1a.	0.455
ENSPFOP00000000962	LOC103138778	ENSPFOP00000000962	ENSPFOP00000009547	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.524
ENSPFOP00000000962	LOC103148401	ENSPFOP00000000962	ENSPFOP00000017883	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Fibroblast growth factor receptor.	0.593
ENSPFOP00000000962	PIK3R5	ENSPFOP00000000962	ENSPFOP00000005837	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Phosphoinositide-3-kinase regulatory subunit 5.	0.955
ENSPFOP00000000962	PTPRC	ENSPFOP00000000962	ENSPFOP00000022114	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Protein tyrosine phosphatase receptor type C.	0.412
ENSPFOP00000000962	map3k7	ENSPFOP00000000962	ENSPFOP00000013303	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Mitogen-activated protein kinase kinase kinase 7.	0.524
ENSPFOP00000000962	pik3cg	ENSPFOP00000000962	ENSPFOP00000012562	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma; Belongs to the PI3/PI4-kinase family.	0.896
ENSPFOP00000000962	pik3r5	ENSPFOP00000000962	ENSPFOP00000002255	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Phosphoinositide-3-kinase, regulatory subunit 5.	0.989
ENSPFOP00000000962	tgfa	ENSPFOP00000000962	ENSPFOP00000030071	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Transforming growth factor, alpha.	0.494
ENSPFOP00000001361	edn1	ENSPFOP00000001361	ENSPFOP00000005291	Dopamine receptor D4a; Belongs to the G-protein coupled receptor 1 family.	Endothelin 1.	0.741
ENSPFOP00000001361	htr2b	ENSPFOP00000001361	ENSPFOP00000023014	Dopamine receptor D4a; Belongs to the G-protein coupled receptor 1 family.	5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled.	0.568
ENSPFOP00000004812	map2k5	ENSPFOP00000004812	ENSPFOP00000006686	NIMA-related kinase 10.	Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily.	0.644
ENSPFOP00000004812	map2k7	ENSPFOP00000004812	ENSPFOP00000007380	NIMA-related kinase 10.	Mitogen-activated protein kinase kinase 7.	0.539
ENSPFOP00000005800	ENSPFOP00000005958	ENSPFOP00000005800	ENSPFOP00000005958	Teneurin transmembrane protein 1.	Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family.	0.481
ENSPFOP00000005800	ENSPFOP00000029851	ENSPFOP00000005800	ENSPFOP00000029851	Teneurin transmembrane protein 1.	Uncharacterized protein.	0.481
ENSPFOP00000005800	LOC103148401	ENSPFOP00000005800	ENSPFOP00000017883	Teneurin transmembrane protein 1.	Fibroblast growth factor receptor.	0.474