(106 nodes) Negative regulation of MAPK cascade network (Poecilia formosa)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	cav1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (180 aa)
	dusp6	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (385 aa)
	dusp7	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (384 aa)
	ENSPFOP00000011063	Protein tyrosine phosphatase receptor type C. (1210 aa)
	flcn	Folliculin. (554 aa)
	ENSPFOP00000010244	Uncharacterized protein. (638 aa)
	bmp4	Bone morphogenetic protein 4. (401 aa)
	nf2	Neurofibromin 2a (merlin). (591 aa)
	ENSPFOP00000015749	Cylindromatosis (turban tumor syndrome), b. (517 aa)
	cyld	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family. (947 aa)
	LOC103146559	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (195 aa)
	itch	E3 ubiquitin-protein ligase. (869 aa)
	foxm1	Forkhead box M1. (657 aa)
	atf3	Activating transcription factor 3. (259 aa)
	smpd1	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (601 aa)
	dusp27	Dual specificity phosphatase 27; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (1122 aa)
	agt	Angiotensinogen; Belongs to the serpin family. (461 aa)
	cdk5rap3	CDK5 regulatory subunit associated protein 3. (506 aa)
	DUSP26	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (200 aa)
	ENSPFOP00000018865	WNK lysine deficient protein kinase 2. (2108 aa)
	aida	Axin interactor, dorsalization associated. (305 aa)
	dusp10	Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (476 aa)
	ENSPFOP00000019114	Si:dkey-175m17.7. (881 aa)
	LOC103149412	Mothers against decapentaplegic homolog. (503 aa)
	ENSPFOP00000019994	Mothers against decapentaplegic homolog. (511 aa)
	SPRY3	Sprouty RTK signaling antagonist 3. (294 aa)
	LOC103129995	Dystroglycan 1. (892 aa)
	ENSPFOP00000009279	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (372 aa)
	LOC103136288	Bone morphogenetic protein 16. (512 aa)
	TIMP3	TIMP metallopeptidase inhibitor 3. (214 aa)
	LOC103144472	Ash1 (absent, small, or homeotic)-like (Drosophila). (2933 aa)
	phb	Prohibitin. (271 aa)
	ENSPFOP00000008678	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (188 aa)
	ENSPFOP00000020747	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (353 aa)
	spry1	Sprouty homolog 1, antagonist of FGF signaling (Drosophila). (358 aa)
	LOC103145864	Dual specificity phosphatase 2. (315 aa)
	ENSPFOP00000020955	Sprouty RTK signaling antagonist 2. (326 aa)
	ENSPFOP00000020992	Uncharacterized protein. (135 aa)
	LOC103138998	Inhibitor_Mig-6 domain-containing protein. (369 aa)
	ENSPFOP00000021252	3-hydroxy-3-methylglutaryl coenzyme A reductase. (815 aa)
	LOC103140800	Ephrin-A1b; Belongs to the ephrin family. (232 aa)
	ENSPFOP00000021337	Cylindromatosis (turban tumor syndrome), like; Belongs to the peptidase C19 family. (769 aa)
	dact1	Dishevelled binding antagonist of beta catenin 1. (852 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (704 aa)
	ENSPFOP00000022179	Sprouty related EVH1 domain containing 3. (403 aa)
	LOC103131732	Uncharacterized protein. (478 aa)
	LOC103135179	Tyrosine-protein phosphatase non-receptor type. (404 aa)
	spred1	Sprouty related EVH1 domain containing 1. (443 aa)
	SMAD4	Mothers against decapentaplegic homolog. (510 aa)
	LOC103145080	WNK lysine deficient protein kinase 2. (2703 aa)
	PEBP4	Phosphatidylethanolamine binding protein 4. (256 aa)
	dusp5	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (376 aa)
	LOC103141828	Peptidase S72 domain-containing protein. (907 aa)
	ENSPFOP00000008511	Uncharacterized protein. (311 aa)
	LOC103134055	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (213 aa)
	ENSPFOP00000008362	Dual specificity phosphatase 13a; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (376 aa)
	ENSPFOP00000027399	Uncharacterized protein. (1912 aa)
	ENSPFOP00000027641	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (190 aa)
	LOC103150700	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (202 aa)
	ENSPFOP00000010339	Tyrosine-protein phosphatase non-receptor type. (410 aa)
	LOC103139469	Neurofibromin 2b (merlin). (591 aa)
	ENSPFOP00000010700	Dual specificity phosphatase 19a. (202 aa)
	itgb1bp1	Integrin beta 1 binding protein 1. (198 aa)
	LOC103129410	Elastin microfibril interfacer 1b. (1099 aa)
	spred2	Sprouty related EVH1 domain containing 2a. (426 aa)
	sorl1	Sortilin_C domain-containing protein. (996 aa)
	LOC103152451	Uncharacterized protein. (465 aa)
	ENSPFOP00000001687	VRK serine/threonine kinase 3. (431 aa)
	tmem130	PKD domain-containing protein. (308 aa)
	LOC103148823	Elastin microfibril interfacer 1a. (1022 aa)
	tnip1	TNFAIP3 interacting protein 1. (659 aa)
	LOC103144628	Uncharacterized protein. (964 aa)
	ENSPFOP00000002729	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (155 aa)
	LOC103145732	Progestin and adipoQ receptor family member IIIb. (315 aa)
	ENSPFOP00000004680	Peptidyl-prolyl cis-trans isomerase. (217 aa)
	ENSPFOP00000004769	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (374 aa)
	sh2b3	SH2B adaptor protein 3. (710 aa)
	LOC103132185	3-hydroxy-3-methylglutaryl coenzyme A reductase. (873 aa)
	nf1	Neurofibromin 1b. (2774 aa)
	ENSPFOP00000005486	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (440 aa)
	LOC103143481	Apolipoprotein Ea. (251 aa)
	LOC103151897	Dual specificity phosphatase 19. (203 aa)
	SPRY4	Sprouty RTK signaling antagonist 4. (381 aa)
	ENSPFOP00000006522	Sprouty homolog 4 (Drosophila). (283 aa)
	dusp1	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (376 aa)
	fktn	Fukutin. (429 aa)
	men1	Multiple endocrine neoplasia I. (627 aa)
	qars1	Glutaminyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (780 aa)
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	mecom	MDS1 and EVI1 complex locus. (1255 aa)
	LOC103135855	3-hydroxy-3-methylglutaryl coenzyme A reductase. (873 aa)
	zmynd11	Zinc finger, MYND-type containing 11. (665 aa)
	dab2	DAB adaptor protein 2. (756 aa)
	LOC103144485	Ephrin-A1a; Belongs to the ephrin family. (220 aa)
	p2rx7	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (577 aa)
	LOC103141587	Apolipoprotein Eb. (265 aa)
	ENSPFOP00000007914	Si:ch211-153j24.3. (357 aa)
	LOC103139099	Tyrosine-protein phosphatase non-receptor type. (431 aa)
	psmd10	Proteasome 26S subunit, non-ATPase 10. (226 aa)
	LOC103139674	C18h3orf33 homolog (H. sapiens). (268 aa)
	ENSPFOP00000012174	Progestin and adipoQ receptor family member IIIa. (347 aa)
	ENSPFOP00000013739	Protein tyrosine phosphatase non-receptor type 5. (407 aa)
	ENSPFOP00000014180	E3 ubiquitin-protein ligase. (882 aa)
	errfi1	ERBB receptor feedback inhibitor 1a. (419 aa)
	gba	Glucosylceramidase. (522 aa)
	PRDM15	PR/SET domain 15. (1233 aa)

Your Current Organism:

Poecilia formosa

NCBI taxonomy Id: 48698
Other names: Amazon molly, Limia formosa, Mollienesia formosa, P. formosa

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DUSP26	ENSPFOP00000001687	ENSPFOP00000018777	ENSPFOP00000001687	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	VRK serine/threonine kinase 3.	0.633
DUSP26	ENSPFOP00000009279	ENSPFOP00000018777	ENSPFOP00000009279	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.451
DUSP26	ENSPFOP00000013739	ENSPFOP00000018777	ENSPFOP00000013739	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Protein tyrosine phosphatase non-receptor type 5.	0.563
DUSP26	ENSPFOP00000020992	ENSPFOP00000018777	ENSPFOP00000020992	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Uncharacterized protein.	0.425
DUSP26	LOC103131732	ENSPFOP00000018777	ENSPFOP00000023379	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Uncharacterized protein.	0.508
DUSP26	dusp6	ENSPFOP00000018777	ENSPFOP00000014744	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.451
DUSP26	dusp7	ENSPFOP00000018777	ENSPFOP00000011341	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.451
DUSP26	sorl1	ENSPFOP00000018777	ENSPFOP00000000864	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Sortilin_C domain-containing protein.	0.508
ENSPFOP00000001687	DUSP26	ENSPFOP00000001687	ENSPFOP00000018777	VRK serine/threonine kinase 3.	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.633
ENSPFOP00000001687	ENSPFOP00000004769	ENSPFOP00000001687	ENSPFOP00000004769	VRK serine/threonine kinase 3.	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.525
ENSPFOP00000001687	ENSPFOP00000008362	ENSPFOP00000001687	ENSPFOP00000008362	VRK serine/threonine kinase 3.	Dual specificity phosphatase 13a; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.633
ENSPFOP00000001687	ENSPFOP00000008511	ENSPFOP00000001687	ENSPFOP00000008511	VRK serine/threonine kinase 3.	Uncharacterized protein.	0.426
ENSPFOP00000001687	ENSPFOP00000008678	ENSPFOP00000001687	ENSPFOP00000008678	VRK serine/threonine kinase 3.	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.633
ENSPFOP00000001687	ENSPFOP00000010700	ENSPFOP00000001687	ENSPFOP00000010700	VRK serine/threonine kinase 3.	Dual specificity phosphatase 19a.	0.525
ENSPFOP00000001687	ENSPFOP00000019114	ENSPFOP00000001687	ENSPFOP00000019114	VRK serine/threonine kinase 3.	Si:dkey-175m17.7.	0.525
ENSPFOP00000001687	ENSPFOP00000027641	ENSPFOP00000001687	ENSPFOP00000027641	VRK serine/threonine kinase 3.	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.633
ENSPFOP00000001687	LOC103134055	ENSPFOP00000001687	ENSPFOP00000008397	VRK serine/threonine kinase 3.	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.633
ENSPFOP00000001687	LOC103145864	ENSPFOP00000001687	ENSPFOP00000010293	VRK serine/threonine kinase 3.	Dual specificity phosphatase 2.	0.525
ENSPFOP00000001687	LOC103146559	ENSPFOP00000001687	ENSPFOP00000016066	VRK serine/threonine kinase 3.	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.633
ENSPFOP00000001687	LOC103151897	ENSPFOP00000001687	ENSPFOP00000006393	VRK serine/threonine kinase 3.	Dual specificity phosphatase 19.	0.525