(81 nodes) Positive regulation of angiogenesis network (Poecilia formosa)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	JMJD8	Jumonji domain containing 8. (316 aa)
	LOC103129410	Elastin microfibril interfacer 1b. (1099 aa)
	LOC103131656	Uncharacterized protein. (290 aa)
	LOC103129920	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (210 aa)
	ENSPFOP00000000889	PH domain-containing protein. (749 aa)
	ENSPFOP00000001450	Integrin beta; Belongs to the integrin beta chain family. (611 aa)
	ENSPFOP00000001737	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (393 aa)
	LOC103154543	Dimethylarginine dimethylaminohydrolase 2. (290 aa)
	LOC103148823	Elastin microfibril interfacer 1a. (1022 aa)
	LOC103132862	Si:dkey-206d17.12. (370 aa)
	LOC103131252	Junction plakoglobin a. (721 aa)
	brca1	Uncharacterized protein. (1316 aa)
	LOC103151800	Uncharacterized protein. (169 aa)
	DDAH1	Dimethylarginine dimethylaminohydrolase 1. (282 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (536 aa)
	ENSPFOP00000006078	Tyrosine kinase with immunoglobulin-like and EGF-like domains 1. (937 aa)
	ENSPFOP00000006511	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (152 aa)
	LOC103150965	CD40 molecule, TNF receptor superfamily member 5. (313 aa)
	tnn	Tenascin N. (1118 aa)
	aggf1	Angiogenic factor with G patch and FHA domains 1. (752 aa)
	gab1	GRB2-associated binding protein 1. (756 aa)
	LOC103154418	Interleukin-1. (247 aa)
	sp1	Sp1 transcription factor. (687 aa)
	ENSPFOP00000008171	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (251 aa)
	angptl3	Angiopoietin-like 3. (471 aa)
	LOC103136959	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (593 aa)
	ENSPFOP00000008511	Uncharacterized protein. (311 aa)
	btg1	B-cell translocation gene 1, anti-proliferative. (180 aa)
	LOC103140010	Fibrinogen C-terminal domain-containing protein. (480 aa)
	c5	Uncharacterized protein. (1686 aa)
	hspb1	Heat shock protein, alpha-crystallin-related, 1; Belongs to the small heat shock protein (HSP20) family. (200 aa)
	F3	Coagulation factor IIIa. (279 aa)
	ENSPFOP00000009205	Si:ch211-39a7.1. (485 aa)
	sirt1	Sirtuin 1. (677 aa)
	ENSPFOP00000010428	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (159 aa)
	LOC103147504	Si:ch73-380n15.2. (511 aa)
	ENSPFOP00000010597	Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (545 aa)
	mydgf	Myeloid-derived growth factor. (160 aa)
	vegfc	Vascular endothelial growth factor c; Belongs to the PDGF/VEGF growth factor family. (420 aa)
	ENSPFOP00000012018	Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (262 aa)
	ENSPFOP00000012188	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family. (380 aa)
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	ENSPFOP00000012792	Rap guanine nucleotide exchange factor (GEF) 3. (835 aa)
	sirt6	Sirtuin 6. (390 aa)
	LOC103136996	Uncharacterized protein. (537 aa)
	LOC103142217	Receptor (G protein-coupled) activity modifying protein 2. (165 aa)
	LOC103142217-2	Receptor (G protein-coupled) activity modifying protein 2. (213 aa)
	zc3h12a	Zinc finger CCCH-type containing 12A. (627 aa)
	nfe2l2	Nuclear factor, erythroid 2-like 2a. (617 aa)
	LOC103144431	Insulin-like growth factor 2b. (220 aa)
	ENSPFOP00000014553	UTP15 small subunit processome component. (535 aa)
	ENSPFOP00000014582	X-box binding protein 1. (387 aa)
	chrna7	Cholinergic receptor, nicotinic, alpha 7 (neuronal). (510 aa)
	ENSPFOP00000014817	Uncharacterized protein. (515 aa)
	ENSPFOP00000014818	Ninjurin 1. (119 aa)
	ENSPFOP00000015072	Uncharacterized protein. (525 aa)
	ENSPFOP00000015250	SAM and SH3 domain containing 1b. (1060 aa)
	ecm1	Uncharacterized protein. (483 aa)
	cd34	Si:ch211-286o17.1. (318 aa)
	hmga2	Uncharacterized protein. (115 aa)
	il10	Interleukin 10. (181 aa)
	ENSPFOP00000016871	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (272 aa)
	LOC103155237	Protein S100; Belongs to the S-100 family. (105 aa)
	ENSPFOP00000018418	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (158 aa)
	LOC103137301	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
	ENSPFOP00000018514	BMP binding endothelial regulator. (693 aa)
	LOC103138101	Ninjurin 1. (150 aa)
	ENSPFOP00000019409	Uncharacterized protein. (327 aa)
	LOC103130769	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (782 aa)
	ENSPFOP00000019732	SAM and SH3 domain containing 1a. (1223 aa)
	LOC103149046	Heat shock protein, alpha-crystallin-related, b15; Belongs to the small heat shock protein (HSP20) family. (199 aa)
	ENSPFOP00000020077	Apelin receptor b; Belongs to the G-protein coupled receptor 1 family. (357 aa)
	LOC103146723	Apelin receptor a; Belongs to the G-protein coupled receptor 1 family. (361 aa)
	ENSPFOP00000020808	Cytochrome P450, family 1, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family. (525 aa)
	GREM1	Gremlin. (182 aa)
	ctsh	Cathepsin H; Belongs to the peptidase C1 family. (325 aa)
	vegfa	Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family. (214 aa)
	tbxa2r	Thromboxane A2 receptor. (383 aa)
	LOC103139223	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (290 aa)
	LOC103135167	Metadherin a. (522 aa)
	ENSPFOP00000028786	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (132 aa)

Your Current Organism:

Poecilia formosa

NCBI taxonomy Id: 48698
Other names: Amazon molly, Limia formosa, Mollienesia formosa, P. formosa

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPFOP00000000889	ENSPFOP00000006078	ENSPFOP00000000889	ENSPFOP00000006078	PH domain-containing protein.	Tyrosine kinase with immunoglobulin-like and EGF-like domains 1.	0.528
ENSPFOP00000000889	ENSPFOP00000006511	ENSPFOP00000000889	ENSPFOP00000006511	PH domain-containing protein.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.560
ENSPFOP00000000889	ENSPFOP00000010428	ENSPFOP00000000889	ENSPFOP00000010428	PH domain-containing protein.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.560
ENSPFOP00000001450	LOC103140010	ENSPFOP00000001450	ENSPFOP00000008794	Integrin beta; Belongs to the integrin beta chain family.	Fibrinogen C-terminal domain-containing protein.	0.508
ENSPFOP00000001450	angptl3	ENSPFOP00000001450	ENSPFOP00000008256	Integrin beta; Belongs to the integrin beta chain family.	Angiopoietin-like 3.	0.508
ENSPFOP00000001450	tnn	ENSPFOP00000001450	ENSPFOP00000006583	Integrin beta; Belongs to the integrin beta chain family.	Tenascin N.	0.870
ENSPFOP00000006078	ENSPFOP00000000889	ENSPFOP00000006078	ENSPFOP00000000889	Tyrosine kinase with immunoglobulin-like and EGF-like domains 1.	PH domain-containing protein.	0.528
ENSPFOP00000006078	ENSPFOP00000006511	ENSPFOP00000006078	ENSPFOP00000006511	Tyrosine kinase with immunoglobulin-like and EGF-like domains 1.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.784
ENSPFOP00000006078	ENSPFOP00000008171	ENSPFOP00000006078	ENSPFOP00000008171	Tyrosine kinase with immunoglobulin-like and EGF-like domains 1.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.886
ENSPFOP00000006078	ENSPFOP00000010428	ENSPFOP00000006078	ENSPFOP00000010428	Tyrosine kinase with immunoglobulin-like and EGF-like domains 1.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.784
ENSPFOP00000006078	ENSPFOP00000016871	ENSPFOP00000006078	ENSPFOP00000016871	Tyrosine kinase with immunoglobulin-like and EGF-like domains 1.	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family.	0.842
ENSPFOP00000006078	ENSPFOP00000018418	ENSPFOP00000006078	ENSPFOP00000018418	Tyrosine kinase with immunoglobulin-like and EGF-like domains 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.853
ENSPFOP00000006078	ENSPFOP00000028786	ENSPFOP00000006078	ENSPFOP00000028786	Tyrosine kinase with immunoglobulin-like and EGF-like domains 1.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.870
ENSPFOP00000006078	LOC103129920	ENSPFOP00000006078	ENSPFOP00000000563	Tyrosine kinase with immunoglobulin-like and EGF-like domains 1.	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family.	0.781
ENSPFOP00000006078	LOC103130769	ENSPFOP00000006078	ENSPFOP00000019656	Tyrosine kinase with immunoglobulin-like and EGF-like domains 1.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.601
ENSPFOP00000006078	LOC103131252	ENSPFOP00000006078	ENSPFOP00000003396	Tyrosine kinase with immunoglobulin-like and EGF-like domains 1.	Junction plakoglobin a.	0.425
ENSPFOP00000006078	LOC103137301	ENSPFOP00000006078	ENSPFOP00000018464	Tyrosine kinase with immunoglobulin-like and EGF-like domains 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.781
ENSPFOP00000006078	LOC103140010	ENSPFOP00000006078	ENSPFOP00000008794	Tyrosine kinase with immunoglobulin-like and EGF-like domains 1.	Fibrinogen C-terminal domain-containing protein.	0.553
ENSPFOP00000006078	LOC103144431	ENSPFOP00000006078	ENSPFOP00000014167	Tyrosine kinase with immunoglobulin-like and EGF-like domains 1.	Insulin-like growth factor 2b.	0.751
ENSPFOP00000006078	angptl3	ENSPFOP00000006078	ENSPFOP00000008256	Tyrosine kinase with immunoglobulin-like and EGF-like domains 1.	Angiopoietin-like 3.	0.553