(48 nodes) Positive regulation of endocytosis network (Poecilia formosa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSPFOP00000011880	Leucine-rich repeat kinase 2. (1882 aa)
	eef2k	Eukaryotic elongation factor 2 kinase. (775 aa)
	ENSPFOP00000012188	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family. (380 aa)
	vps28	Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. (223 aa)
	pick1	Protein interacting with prkca 1. (409 aa)
	ntf3	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (304 aa)
	ENSPFOP00000013739	Protein tyrosine phosphatase non-receptor type 5. (407 aa)
	LOC103136751	Uncharacterized protein. (191 aa)
	LOC103136753	Uncharacterized protein. (191 aa)
	pcsk9	Uncharacterized protein. (499 aa)
	clu	Clusterin; Belongs to the clusterin family. (461 aa)
	ano6	Anoctamin. (918 aa)
	ENSPFOP00000016741	Membrane associated guanylate kinase, WW and PDZ domain containing 2a. (1299 aa)
	ENSPFOP00000016979	Clusterin; Belongs to the clusterin family. (458 aa)
	ENSPFOP00000017050	Membrane associated guanylate kinase, WW and PDZ domain containing 2b. (940 aa)
	smpd1	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (601 aa)
	ENSPFOP00000018147	Abelson helper integration site 1. (920 aa)
	LOC103141587	Apolipoprotein Eb. (265 aa)
	SCYL2	SCY1 like pseudokinase 2. (921 aa)
	cd63	Tetraspanin. (240 aa)
	LOC103139167	Vitronectin b. (444 aa)
	appl1	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1. (708 aa)
	ENSPFOP00000009425	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2. (666 aa)
	LOC103146449	Uncharacterized protein. (191 aa)
	ENSPFOP00000009709	SCY domain-containing protein. (112 aa)
	dab2	DAB adaptor protein 2. (756 aa)
	ankfy1	Ankyrin repeat and FYVE domain containing 1. (1166 aa)
	GREM1	Gremlin. (182 aa)
	ENSPFOP00000021138	Zgc:123278. (134 aa)
	LOC103147496	Uncharacterized protein. (370 aa)
	vegfa	Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family. (214 aa)
	ENSPFOP00000025550	Battenin. (445 aa)
	CDC42	Cell division cycle 42. (191 aa)
	ENSPFOP00000030671	Uncharacterized protein. (135 aa)
	ENSPFOP00000000376	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (392 aa)
	ppt1	Palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile). (303 aa)
	tsg101	Tumor susceptibility 101a. (390 aa)
	tsg101-2	Tumor susceptibility gene 101 protein-like. (390 aa)
	cbll1	Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase. (477 aa)
	LOC103135681	Clusterin; Belongs to the clusterin family. (464 aa)
	LOC103144092	Cell division cycle 42. (191 aa)
	ENSPFOP00000004344	Fragile X mental retardation 1. (607 aa)
	tbc1d5	TBC1 domain family, member 5. (876 aa)
	ldlrap1	Low density lipoprotein receptor adaptor protein 1b. (313 aa)
	LOC103143481	Apolipoprotein Ea. (251 aa)
	LOC103146039	Low density lipoprotein receptor adaptor protein 1a. (308 aa)
	LOC103148732	Calcyon neuron-specific vesicular protein. (202 aa)
	vtn	Vitronectin a. (572 aa)

Your Current Organism:

Poecilia formosa

NCBI taxonomy Id: 48698
Other names: Amazon molly, Limia formosa, Mollienesia formosa, P. formosa

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC42	ENSPFOP00000009425	ENSPFOP00000028086	ENSPFOP00000009425	Cell division cycle 42.	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2.	0.410
CDC42	ENSPFOP00000016741	ENSPFOP00000028086	ENSPFOP00000016741	Cell division cycle 42.	Membrane associated guanylate kinase, WW and PDZ domain containing 2a.	0.558
CDC42	ENSPFOP00000017050	ENSPFOP00000028086	ENSPFOP00000017050	Cell division cycle 42.	Membrane associated guanylate kinase, WW and PDZ domain containing 2b.	0.558
CDC42	ENSPFOP00000030671	ENSPFOP00000028086	ENSPFOP00000030671	Cell division cycle 42.	Uncharacterized protein.	0.778
CDC42	LOC103136751	ENSPFOP00000028086	ENSPFOP00000014394	Cell division cycle 42.	Uncharacterized protein.	0.777
CDC42	LOC103136753	ENSPFOP00000028086	ENSPFOP00000014396	Cell division cycle 42.	Uncharacterized protein.	0.778
CDC42	LOC103146449	ENSPFOP00000028086	ENSPFOP00000009597	Cell division cycle 42.	Uncharacterized protein.	0.863
CDC42	ankfy1	ENSPFOP00000028086	ENSPFOP00000011687	Cell division cycle 42.	Ankyrin repeat and FYVE domain containing 1.	0.666
CDC42	appl1	ENSPFOP00000028086	ENSPFOP00000009116	Cell division cycle 42.	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1.	0.410
ENSPFOP00000000376	LOC103141587	ENSPFOP00000000376	ENSPFOP00000008021	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	Apolipoprotein Eb.	0.449
ENSPFOP00000000376	LOC103143481	ENSPFOP00000000376	ENSPFOP00000005541	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	Apolipoprotein Ea.	0.412
ENSPFOP00000009425	CDC42	ENSPFOP00000009425	ENSPFOP00000028086	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2.	Cell division cycle 42.	0.410
ENSPFOP00000009425	ENSPFOP00000030671	ENSPFOP00000009425	ENSPFOP00000030671	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2.	Uncharacterized protein.	0.410
ENSPFOP00000009425	LOC103136751	ENSPFOP00000009425	ENSPFOP00000014394	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2.	Uncharacterized protein.	0.410
ENSPFOP00000009425	LOC103136753	ENSPFOP00000009425	ENSPFOP00000014396	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2.	Uncharacterized protein.	0.410
ENSPFOP00000009425	LOC103141587	ENSPFOP00000009425	ENSPFOP00000008021	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2.	Apolipoprotein Eb.	0.439
ENSPFOP00000009425	LOC103143481	ENSPFOP00000009425	ENSPFOP00000005541	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2.	Apolipoprotein Ea.	0.439
ENSPFOP00000009425	LOC103144092	ENSPFOP00000009425	ENSPFOP00000004328	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2.	Cell division cycle 42.	0.410
ENSPFOP00000009425	LOC103146039	ENSPFOP00000009425	ENSPFOP00000005557	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2.	Low density lipoprotein receptor adaptor protein 1a.	0.798
ENSPFOP00000009425	LOC103146449	ENSPFOP00000009425	ENSPFOP00000009597	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2.	Uncharacterized protein.	0.410