(75 nodes) Positive regulation of developmental growth network (Poecilia formosa)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103156111	Activity-dependent neuroprotector homeobox b. (1058 aa)
	ENSPFOP00000002513	NMDA receptor synaptonuclear signaling and neuronal migration factor b. (576 aa)
	ENSPFOP00000002578	Agrin. (1833 aa)
	LOC103145185	Si:dkey-40c11.2. (810 aa)
	wnt2b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (384 aa)
	parp2	Poly [ADP-ribose] polymerase. (650 aa)
	smo	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (811 aa)
	ENSPFOP00000004592	Anaphase promoting complex subunit 2; Belongs to the cullin family. (789 aa)
	bmpr2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1041 aa)
	rnd2	Rho family GTPase 2. (245 aa)
	ist1	IST1 factor associated with ESCRT-III. (348 aa)
	edn1	Endothelin 1. (187 aa)
	ENSPFOP00000005486	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (440 aa)
	gpam	Glycerol-3-phosphate acyltransferase 1, mitochondrial. (818 aa)
	LOC103145329	Fibronectin 1a. (2502 aa)
	ENSPFOP00000005809	SH3 domain-containing protein. (283 aa)
	ENSPFOP00000005890	Semaphorin 7A; Belongs to the semaphorin family. (642 aa)
	ENSPFOP00000005910	Immunoglobulin superfamily containing leucine-rich repeat 2. (701 aa)
	ENSPFOP00000005988	RUN and FYVE domain containing 3. (628 aa)
	ppib	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (216 aa)
	mul1	Mitochondrial E3 ubiquitin protein ligase 1b. (352 aa)
	ENSPFOP00000007586	Si:dkey-280e21.3. (460 aa)
	LOC103156726	Si:ch211-113g11.6; Belongs to the semaphorin family. (433 aa)
	LOC103144025	Synaptotagmin IIa. (427 aa)
	ENSPFOP00000008904	Rho family GTPase 2. (250 aa)
	ENSPFOP00000010163	Drebrin 1. (376 aa)
	ENSPFOP00000010303	L1 cell adhesion molecule, paralog a. (1211 aa)
	ENSPFOP00000010742	A kinase (PRKA) anchor protein 6. (2000 aa)
	ENSPFOP00000011972	Growth hormone secretagogue receptor b; Belongs to the G-protein coupled receptor 1 family. (385 aa)
	ENSPFOP00000012615	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
	LOC103145052	Colony stimulating factor 1b (macrophage). (269 aa)
	ENSPFOP00000012942	Drebrin-like b. (480 aa)
	ppard	Peroxisome proliferator-activated receptor delta b. (508 aa)
	ENSPFOP00000014035	Zinc finger protein, FOG family member 2a. (988 aa)
	LOC103132594	Synaptotagmin Vb. (424 aa)
	LOC103144431	Insulin-like growth factor 2b. (220 aa)
	LOC103134608	Uncharacterized protein. (431 aa)
	LOC103149862	Uncharacterized protein; Belongs to the semaphorin family. (611 aa)
	bbs4	Bardet-Biedl syndrome 4. (537 aa)
	golga4	Golgin A4. (2055 aa)
	ENSPFOP00000016051	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1009 aa)
	sash3	SAM and SH3 domain containing 3. (397 aa)
	LOC103143564	Cyclin-dependent kinase-like 5. (1142 aa)
	syt1	Synaptotagmin Ia. (422 aa)
	LOC103133744	Zona pellucida glycoprotein 3. (425 aa)
	wnt3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	igf1	Insulin-like growth factor 1. (186 aa)
	ENSPFOP00000018333	Uncharacterized protein. (155 aa)
	ENSPFOP00000018431	Si:ch211-113g11.6; Belongs to the semaphorin family. (568 aa)
	CDKL5	Cyclin dependent kinase like 5. (1008 aa)
	ENSPFOP00000019034	H2.0-like homeo box 1 (Drosophila). (383 aa)
	ENSPFOP00000019455	DISC1 scaffold protein. (814 aa)
	ENSPFOP00000019606	Spastin; Belongs to the AAA ATPase family. (527 aa)
	mkks	McKusick-Kaufman syndrome. (575 aa)
	ENSPFOP00000019801	NMDA receptor synaptonuclear signaling and neuronal migration factor a. (532 aa)
	ENSPFOP00000020257	Nerve growth factor a (beta polypeptide); Belongs to the NGF-beta family. (249 aa)
	LOC103142633	Ig-like domain-containing protein. (693 aa)
	bcl2	BCL2 apoptosis regulator b. (229 aa)
	rnf157	Ring finger protein 157. (663 aa)
	ENSPFOP00000030391	MADS-box domain-containing protein. (378 aa)
	ENSPFOP00000023146	Parvalbumin 9; Belongs to the parvalbumin family. (99 aa)
	zfyve27	Zinc finger, FYVE domain containing 27. (411 aa)
	ENSPFOP00000025013	Uncharacterized protein. (1837 aa)
	ENSPFOP00000025195	NGF domain-containing protein; Belongs to the NGF-beta family. (103 aa)
	ENSPFOP00000025895	ZP domain-containing protein. (174 aa)
	ENSPFOP00000026162	Serum response factor b. (601 aa)
	nol12	Nucleolar protein 12. (238 aa)
	ENSPFOP00000028949	Shootin 1. (348 aa)
	shtn1	Shootin 1. (366 aa)
	ENSPFOP00000029965	Uncharacterized protein. (156 aa)
	plaa	Phospholipase A2-activating protein. (798 aa)
	ENSPFOP00000000448	NtA domain-containing protein. (160 aa)
	ENSPFOP00000000964	NtA domain-containing protein. (166 aa)
	LOC103149606	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
	LOC103153468	Uncharacterized protein. (1285 aa)

Your Current Organism:

Poecilia formosa

NCBI taxonomy Id: 48698
Other names: Amazon molly, Limia formosa, Mollienesia formosa, P. formosa

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPFOP00000000448	ENSPFOP00000002578	ENSPFOP00000000448	ENSPFOP00000002578	NtA domain-containing protein.	Agrin.	0.738
ENSPFOP00000000964	ENSPFOP00000002578	ENSPFOP00000000964	ENSPFOP00000002578	NtA domain-containing protein.	Agrin.	0.727
ENSPFOP00000002578	ENSPFOP00000000448	ENSPFOP00000002578	ENSPFOP00000000448	Agrin.	NtA domain-containing protein.	0.738
ENSPFOP00000002578	ENSPFOP00000000964	ENSPFOP00000002578	ENSPFOP00000000964	Agrin.	NtA domain-containing protein.	0.727
ENSPFOP00000004592	ENSPFOP00000019606	ENSPFOP00000004592	ENSPFOP00000019606	Anaphase promoting complex subunit 2; Belongs to the cullin family.	Spastin; Belongs to the AAA ATPase family.	0.591
ENSPFOP00000004592	bbs4	ENSPFOP00000004592	ENSPFOP00000015623	Anaphase promoting complex subunit 2; Belongs to the cullin family.	Bardet-Biedl syndrome 4.	0.751
ENSPFOP00000005486	ENSPFOP00000008904	ENSPFOP00000005486	ENSPFOP00000008904	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	Rho family GTPase 2.	0.581
ENSPFOP00000005486	LOC103145329	ENSPFOP00000005486	ENSPFOP00000005553	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	Fibronectin 1a.	0.492
ENSPFOP00000005486	bcl2	ENSPFOP00000005486	ENSPFOP00000021079	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	BCL2 apoptosis regulator b.	0.729
ENSPFOP00000005486	mul1	ENSPFOP00000005486	ENSPFOP00000007538	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	Mitochondrial E3 ubiquitin protein ligase 1b.	0.646
ENSPFOP00000005486	rnd2	ENSPFOP00000005486	ENSPFOP00000004793	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	Rho family GTPase 2.	0.581
ENSPFOP00000005910	igf1	ENSPFOP00000005910	ENSPFOP00000018036	Immunoglobulin superfamily containing leucine-rich repeat 2.	Insulin-like growth factor 1.	0.594
ENSPFOP00000005988	ENSPFOP00000007586	ENSPFOP00000005988	ENSPFOP00000007586	RUN and FYVE domain containing 3.	Si:dkey-280e21.3.	0.478
ENSPFOP00000005988	shtn1	ENSPFOP00000005988	ENSPFOP00000030381	RUN and FYVE domain containing 3.	Shootin 1.	0.478
ENSPFOP00000007586	ENSPFOP00000005988	ENSPFOP00000007586	ENSPFOP00000005988	Si:dkey-280e21.3.	RUN and FYVE domain containing 3.	0.478
ENSPFOP00000007586	ENSPFOP00000010303	ENSPFOP00000007586	ENSPFOP00000010303	Si:dkey-280e21.3.	L1 cell adhesion molecule, paralog a.	0.516
ENSPFOP00000007586	LOC103153468	ENSPFOP00000007586	ENSPFOP00000001745	Si:dkey-280e21.3.	Uncharacterized protein.	0.516
ENSPFOP00000008904	ENSPFOP00000005486	ENSPFOP00000008904	ENSPFOP00000005486	Rho family GTPase 2.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.581
ENSPFOP00000008904	golga4	ENSPFOP00000008904	ENSPFOP00000015777	Rho family GTPase 2.	Golgin A4.	0.587
ENSPFOP00000010303	ENSPFOP00000007586	ENSPFOP00000010303	ENSPFOP00000007586	L1 cell adhesion molecule, paralog a.	Si:dkey-280e21.3.	0.516