(97 nodes) Regulation of lymphocyte proliferation network (Poecilia formosa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSPFOP00000000066	Uncharacterized protein. (375 aa)
	LOC103139032	Tumor necrosis factor receptor superfamily, member 9a. (296 aa)
	ENSPFOP00000000523	Spleen tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. (451 aa)
	ENSPFOP00000000867	Nuclear factor of activated T cells 2a. (848 aa)
	LOC103155324	TNFR-Cys domain-containing protein. (260 aa)
	LOC103133028	Galectin. (330 aa)
	tirap	Toll-interleukin 1 receptor (TIR) domain containing adaptor protein. (231 aa)
	ENSPFOP00000003130	Uncharacterized protein. (300 aa)
	LOC103153225	Uncharacterized protein. (896 aa)
	LOC103146131	Leucine rich repeat containing 32. (655 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (580 aa)
	ENSPFOP00000003699	Uncharacterized protein. (381 aa)
	LOC103146961	Uncharacterized protein. (294 aa)
	AIF1	Allograft inflammatory factor 1. (147 aa)
	ENSPFOP00000004857	Caspase recruitment domain family, member 11. (1146 aa)
	rc3h1	Ring finger and CCCH-type domains 1b. (1120 aa)
	gpam	Glycerol-3-phosphate acyltransferase 1, mitochondrial. (818 aa)
	ENSPFOP00000005856	Arginase. (346 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (536 aa)
	ENSPFOP00000006139	Uncharacterized protein. (306 aa)
	ENSPFOP00000006155	Uncharacterized protein. (255 aa)
	ENSPFOP00000006168	ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (3081 aa)
	ENSPFOP00000006342	Glycoprotein (transmembrane) nmb. (588 aa)
	LOC103150965	CD40 molecule, TNF receptor superfamily member 5. (313 aa)
	SLC7A1	Solute carrier family 7 member 1. (630 aa)
	LOC103154418	Interleukin-1. (247 aa)
	LOC103155181	Interleukin 12 receptor, beta 2a. (798 aa)
	LOC103136959	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (593 aa)
	sos1	Son of sevenless homolog 1 (Drosophila). (1329 aa)
	crtam	Uncharacterized protein. (443 aa)
	ENSPFOP00000009709	SCY domain-containing protein. (112 aa)
	lgals12	Galectin. (315 aa)
	ENSPFOP00000010692	Uncharacterized protein. (289 aa)
	ENSPFOP00000010720	Uncharacterized protein. (306 aa)
	tnfsf13b	TNF superfamily member 13b; Belongs to the tumor necrosis factor family. (223 aa)
	ENSPFOP00000011063	Protein tyrosine phosphatase receptor type C. (1210 aa)
	LOC103147771	Galectin. (277 aa)
	ENSPFOP00000011961	Mitotic arrest deficient 1 like 1. (676 aa)
	LOC103154739	Tumor necrosis factor receptor superfamily, member 21. (687 aa)
	dhps	Deoxyhypusine synthase. (365 aa)
	LOC103141722	ATPase family AAA domain containing 5a. (1812 aa)
	ENSPFOP00000013140	Uncharacterized protein. (662 aa)
	LOC103140155	CD40 ligand; Belongs to the tumor necrosis factor family. (237 aa)
	nck1	Cytoplasmic protein. (394 aa)
	LOC103144431	Insulin-like growth factor 2b. (220 aa)
	ENSPFOP00000014180	E3 ubiquitin-protein ligase. (882 aa)
	dlg5	Discs, large homolog 5a (Drosophila); Belongs to the MAGUK family. (2011 aa)
	LOC103136547	Tumor necrosis factor receptor superfamily, member 1B. (440 aa)
	LOC103153862	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (202 aa)
	vsir	V-set immunoregulatory receptor. (289 aa)
	nck2	Cytoplasmic protein. (393 aa)
	ENSPFOP00000015505	Tyrosine-protein kinase. (621 aa)
	LOC103138264	Transforming growth factor beta; Belongs to the TGF-beta family. (380 aa)
	marchf7	Membrane-associated ring finger (C3HC4) 7. (785 aa)
	cd276	CD276 molecule. (310 aa)
	ENSPFOP00000016226	Uncharacterized protein. (218 aa)
	itch	E3 ubiquitin-protein ligase. (869 aa)
	il10	Interleukin 10. (181 aa)
	RASSF5	Ras association domain family member 5. (271 aa)
	sash3	SAM and SH3 domain containing 3. (397 aa)
	sos2	Son of sevenless homolog 2 (Drosophila). (1325 aa)
	LOC103144739	Galectin. (373 aa)
	ENSPFOP00000017338	Glomulin, FKBP associated protein a. (612 aa)
	ENSPFOP00000017787	PRKC, apoptosis, WT1, regulator. (344 aa)
	LOC103133744	Zona pellucida glycoprotein 3. (425 aa)
	ENSPFOP00000017928	V-set domain containing T cell activation inhibitor 1. (274 aa)
	arg2	Arginase. (346 aa)
	LOC103140703	Solute carrier family 7 member 1a. (501 aa)
	igf1	Insulin-like growth factor 1. (186 aa)
	ENSPFOP00000018243	Uncharacterized protein; Belongs to the protein kinase superfamily. (460 aa)
	ENSPFOP00000018448	Galectin. (263 aa)
	sh3rf1	SH3 domain containing ring finger 1. (851 aa)
	ENSPFOP00000019366	Ig-like domain-containing protein. (171 aa)
	LOC103147560	Uncharacterized protein. (277 aa)
	ENSPFOP00000019830	Uncharacterized protein. (264 aa)
	ENSPFOP00000021076	CCAAT enhancer binding protein beta. (287 aa)
	ENSPFOP00000021970	Ig-like domain-containing protein. (223 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (704 aa)
	ENSPFOP00000022140	Uncharacterized protein. (458 aa)
	ENSPFOP00000023273	Glycoprotein (transmembrane) nmb. (502 aa)
	ENSPFOP00000023509	Uncharacterized protein. (221 aa)
	ENSPFOP00000023628	Spleen tyrosine kinase. (245 aa)
	ENSPFOP00000023731	Ig-like domain-containing protein. (178 aa)
	ENSPFOP00000024384	Transmembrane 131 like. (1047 aa)
	tnfrsf13b	TACI-CRD2 domain-containing protein. (290 aa)
	ENSPFOP00000025895	ZP domain-containing protein. (174 aa)
	ENSPFOP00000026331	Uncharacterized protein. (197 aa)
	LOC103147559	Uncharacterized protein. (332 aa)
	ENSPFOP00000027343	Si:dkey-40g16.6. (257 aa)
	LOC103139032-2	Tumor necrosis factor receptor superfamily member 9-like. (296 aa)
	LOC103152142	Uncharacterized protein. (272 aa)
	inpp5d	Inositol polyphosphate-5-phosphatase D. (1083 aa)
	ENSPFOP00000029451	Ig-like domain-containing protein. (278 aa)
	ENSPFOP00000030409	Uncharacterized protein. (342 aa)
	ENSPFOP00000030500	Nuclear factor of activated T cells 2a. (520 aa)
	ENSPFOP00000030674	IGv domain-containing protein. (197 aa)
	LOC103152203	Interferon regulatory factor. (291 aa)

Your Current Organism:

Poecilia formosa

NCBI taxonomy Id: 48698
Other names: Amazon molly, Limia formosa, Mollienesia formosa, P. formosa

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIF1	ENSPFOP00000004857	ENSPFOP00000003901	ENSPFOP00000004857	Allograft inflammatory factor 1.	Caspase recruitment domain family, member 11.	0.435
AIF1	LOC103154418	ENSPFOP00000003901	ENSPFOP00000007585	Allograft inflammatory factor 1.	Interleukin-1.	0.592
AIF1	dlg5	ENSPFOP00000003901	ENSPFOP00000014322	Allograft inflammatory factor 1.	Discs, large homolog 5a (Drosophila); Belongs to the MAGUK family.	0.435
AIF1	il10	ENSPFOP00000003901	ENSPFOP00000016664	Allograft inflammatory factor 1.	Interleukin 10.	0.443
ENSPFOP00000000066	ENSPFOP00000019830	ENSPFOP00000000066	ENSPFOP00000019830	Uncharacterized protein.	Uncharacterized protein.	0.716
ENSPFOP00000000066	ENSPFOP00000030674	ENSPFOP00000000066	ENSPFOP00000030674	Uncharacterized protein.	IGv domain-containing protein.	0.443
ENSPFOP00000000523	ENSPFOP00000004857	ENSPFOP00000000523	ENSPFOP00000004857	Spleen tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Caspase recruitment domain family, member 11.	0.639
ENSPFOP00000000523	ENSPFOP00000006168	ENSPFOP00000000523	ENSPFOP00000006168	Spleen tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family.	ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.494
ENSPFOP00000000523	ENSPFOP00000011063	ENSPFOP00000000523	ENSPFOP00000011063	Spleen tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Protein tyrosine phosphatase receptor type C.	0.482
ENSPFOP00000000523	ENSPFOP00000014180	ENSPFOP00000000523	ENSPFOP00000014180	Spleen tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family.	E3 ubiquitin-protein ligase.	0.444
ENSPFOP00000000523	ENSPFOP00000023628	ENSPFOP00000000523	ENSPFOP00000023628	Spleen tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Spleen tyrosine kinase.	0.720
ENSPFOP00000000523	ENSPFOP00000030674	ENSPFOP00000000523	ENSPFOP00000030674	Spleen tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family.	IGv domain-containing protein.	0.408
ENSPFOP00000000523	LOC103144431	ENSPFOP00000000523	ENSPFOP00000014167	Spleen tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Insulin-like growth factor 2b.	0.528
ENSPFOP00000000523	PTPRC	ENSPFOP00000000523	ENSPFOP00000022114	Spleen tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Protein tyrosine phosphatase receptor type C.	0.482
ENSPFOP00000000523	igf1	ENSPFOP00000000523	ENSPFOP00000018036	Spleen tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Insulin-like growth factor 1.	0.543
ENSPFOP00000000523	il10	ENSPFOP00000000523	ENSPFOP00000016664	Spleen tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Interleukin 10.	0.480
ENSPFOP00000000523	itch	ENSPFOP00000000523	ENSPFOP00000016446	Spleen tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family.	E3 ubiquitin-protein ligase.	0.444
ENSPFOP00000000523	nck1	ENSPFOP00000000523	ENSPFOP00000013873	Spleen tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Cytoplasmic protein.	0.523
ENSPFOP00000000523	nck2	ENSPFOP00000000523	ENSPFOP00000015331	Spleen tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Cytoplasmic protein.	0.523
ENSPFOP00000000523	sos1	ENSPFOP00000000523	ENSPFOP00000009229	Spleen tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Son of sevenless homolog 1 (Drosophila).	0.490