(145 nodes) Positive regulation of neurogenesis network (Poecilia formosa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103148157	Homeobox protein Nkx-6.2-like. (281 aa)
	ENSPFOP00000005994	Adhesion molecule with Ig-like domain 3. (504 aa)
	ENSPFOP00000005988	RUN and FYVE domain containing 3. (628 aa)
	xrcc5	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (722 aa)
	ENSPFOP00000000442	Plexin_cytopl domain-containing protein. (283 aa)
	lig4	DNA ligase. (908 aa)
	LOC103149606	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
	LOC103154709	Neuroplastin b. (390 aa)
	ENSPFOP00000001341	RECA_2 domain-containing protein. (301 aa)
	ENSPFOP00000001385	TIR domain-containing protein. (359 aa)
	ENSPFOP00000001597	Uncharacterized protein. (312 aa)
	ENSPFOP00000030526	Zinc finger protein 16 like. (539 aa)
	ENSPFOP00000030391	MADS-box domain-containing protein. (378 aa)
	shtn1	Shootin 1. (366 aa)
	LOC103147036	BAI1 associated protein 2. (533 aa)
	ENSPFOP00000029821	Aspartoacylase. (313 aa)
	ENSPFOP00000029819	Uncharacterized protein. (609 aa)
	ENSPFOP00000029161	annotation not available (253 aa)
	ENSPFOP00000028949	Shootin 1. (348 aa)
	ENSPFOP00000028695	Sema domain-containing protein. (461 aa)
	ENSPFOP00000028082	Sema domain-containing protein. (310 aa)
	caprin1	Cell cycle associated protein 1b. (685 aa)
	LOC103130152	Uncharacterized protein. (278 aa)
	ENSPFOP00000026162	Serum response factor b. (601 aa)
	ENSPFOP00000025472	Uncharacterized protein. (313 aa)
	ENSPFOP00000025195	NGF domain-containing protein; Belongs to the NGF-beta family. (103 aa)
	ENSPFOP00000025088	Sema domain-containing protein. (568 aa)
	ENSPFOP00000024963	Plexin_cytopl domain-containing protein. (693 aa)
	ENSPFOP00000024890	Sema domain-containing protein. (569 aa)
	ENSPFOP00000024116	PH domain-containing protein. (301 aa)
	ENSPFOP00000023775	Uncharacterized protein. (548 aa)
	zfyve27	Zinc finger, FYVE domain containing 27. (411 aa)
	ENSPFOP00000023146	Parvalbumin 9; Belongs to the parvalbumin family. (99 aa)
	numb	NUMB endocytic adaptor protein. (661 aa)
	ENSPFOP00000021330	Cut-like homeobox 2b. (1043 aa)
	ENSPFOP00000020997	Fork-head domain-containing protein. (310 aa)
	SLITRK1	SLIT and NTRK like family member 1. (703 aa)
	LOC103141829	Ig-like domain-containing protein. (454 aa)
	LOC103142633	Ig-like domain-containing protein. (693 aa)
	ENSPFOP00000020404	Atonal bHLH transcription factor 7. (140 aa)
	amigo1	Adhesion molecule with Ig-like domain 1. (510 aa)
	ENSPFOP00000020257	Nerve growth factor a (beta polypeptide); Belongs to the NGF-beta family. (249 aa)
	trim32	Tripartite motif containing 32. (679 aa)
	ENSPFOP00000019801	NMDA receptor synaptonuclear signaling and neuronal migration factor a. (532 aa)
	ENSPFOP00000019606	Spastin; Belongs to the AAA ATPase family. (527 aa)
	ENSPFOP00000019455	DISC1 scaffold protein. (814 aa)
	CDKL5	Cyclin dependent kinase like 5. (1008 aa)
	ENSPFOP00000018846	Meteorin like, glial cell differentiation regulator b. (294 aa)
	ENSPFOP00000018827	Trafficking kinesin protein 1. (858 aa)
	ENSPFOP00000018809	Trafficking protein, kinesin binding 1a. (515 aa)
	ENSPFOP00000018804	Trafficking protein, kinesin binding 1a. (884 aa)
	LAYN	Layilin a. (354 aa)
	ENSPFOP00000018431	Si:ch211-113g11.6; Belongs to the semaphorin family. (568 aa)
	LOC103130289	Si:ch1073-335m2.2. (3152 aa)
	ENSPFOP00000018025	Plexin A3. (1646 aa)
	wnt3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	ENSPFOP00000017823	Fork-head domain-containing protein. (304 aa)
	gsx2	GS homeobox 2. (240 aa)
	LOC103154038	Plexin B2. (1861 aa)
	ENSPFOP00000017327	T cell lymphoma invasion and metastasis 1a. (690 aa)
	LOC103143564	Cyclin-dependent kinase-like 5. (1142 aa)
	il1rapl1	Interleukin 1 receptor accessory protein-like 1a. (715 aa)
	LOC103138173	Fas apoptotic inhibitory molecule a. (180 aa)
	LOC103153707	Serine peptidase inhibitor, Kunitz type 1 b. (500 aa)
	PLXNA2	Plexin A2. (1911 aa)
	ENSPFOP00000016051	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1009 aa)
	LOC103138264	Transforming growth factor beta; Belongs to the TGF-beta family. (380 aa)
	LOC103153544	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (439 aa)
	golga4	Golgin A4. (2055 aa)
	fbxw8	F-box and WD repeat domain containing 8. (650 aa)
	il34	Interleukin 34. (225 aa)
	LOC103149862	Uncharacterized protein; Belongs to the semaphorin family. (611 aa)
	ENSPFOP00000015402	Uncharacterized protein. (1227 aa)
	metrn	Meteorin, glial cell differentiation regulator. (302 aa)
	ENSPFOP00000014866	Spen family transcriptional repressor. (2890 aa)
	LOC103142112	Microtubule-associated protein 6a. (462 aa)
	LOC103136547	Tumor necrosis factor receptor superfamily, member 1B. (440 aa)
	PLXND1	Plexin D1. (1904 aa)
	ENSPFOP00000013958	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; Belongs to the serpin family. (454 aa)
	RELN	Reelin. (3467 aa)
	LOC103139156	Plexin A2. (1900 aa)
	ENSPFOP00000013382	Ankyrin repeat domain 27 (VPS9 domain). (1054 aa)
	ENSPFOP00000013014	GATA binding protein 3. (442 aa)
	ENSPFOP00000012942	Drebrin-like b. (480 aa)
	znf335	Zinc finger protein 335. (1579 aa)
	ENSPFOP00000012615	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
	ENSPFOP00000012607	Plexin B3. (1854 aa)
	LOC103151519	Protein tyrosine phosphatase receptor type Z1b. (1438 aa)
	eef2k	Eukaryotic elongation factor 2 kinase. (775 aa)
	ENSPFOP00000011711	TIR domain-containing protein. (410 aa)
	LOC103148456	Uncharacterized protein. (308 aa)
	ENSPFOP00000011279	Forkhead box G1a. (402 aa)
	vegfc	Vascular endothelial growth factor c; Belongs to the PDGF/VEGF growth factor family. (420 aa)
	ENSPFOP00000010469	Plexin b2b. (1854 aa)
	ENSPFOP00000010465	Chondrolectin. (296 aa)
	kdm1a	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (854 aa)
	ENSPFOP00000010303	L1 cell adhesion molecule, paralog a. (1211 aa)
	ENSPFOP00000010163	Drebrin 1. (376 aa)
	ENSPFOP00000010052	Ig-like domain-containing protein. (513 aa)
	dhx36	DEAH (Asp-Glu-Ala-His) box polypeptide 36. (1062 aa)
	ENSPFOP00000009570	NUMB like endocytic adaptor protein. (662 aa)
	spint1	Serine peptidase inhibitor, Kunitz type 1 a. (481 aa)
	LOC103139670	Microtubule-associated protein 6b. (378 aa)
	ENSPFOP00000009024	Caprin family member 2. (715 aa)
	ENSPFOP00000008904	Rho family GTPase 2. (250 aa)
	mtor	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2516 aa)
	ENSPFOP00000008426	Sema domain-containing protein. (1040 aa)
	ENSPFOP00000008302	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa)
	LOC103156726	Si:ch211-113g11.6; Belongs to the semaphorin family. (433 aa)
	ENSPFOP00000007586	Si:dkey-280e21.3. (460 aa)
	LOC103154418	Interleukin-1. (247 aa)
	LOC103140931	BAI1-associated protein 2a. (543 aa)
	LOC103153468	Uncharacterized protein. (1285 aa)
	LOC103156111	Activity-dependent neuroprotector homeobox b. (1058 aa)
	ENSPFOP00000001843	Protein tyrosine phosphatase receptor type Z1a. (1425 aa)
	ENSPFOP00000002179	Methyl CpG binding protein 2. (540 aa)
	ENSPFOP00000002513	NMDA receptor synaptonuclear signaling and neuronal migration factor b. (576 aa)
	plxnb1	Plexin b1b. (2193 aa)
	nkx6-1	NK6 homeobox 1. (328 aa)
	snw1	SNW domain containing 1. (536 aa)
	ENSPFOP00000002968	Plexin b1a. (2137 aa)
	plxna4	Plexin A4. (1914 aa)
	ENSPFOP00000003101	T cell lymphoma invasion and metastasis 1b. (1529 aa)
	LOC103145185	Si:dkey-40c11.2. (810 aa)
	LOC103153225	Uncharacterized protein. (896 aa)
	ENSPFOP00000003455	Si:ch73-330k17.3. (202 aa)
	wnt2b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (384 aa)
	ENSPFOP00000003609	Si:dkey-28e7.3. (798 aa)
	smo	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (811 aa)
	ENSPFOP00000004553	Uncharacterized protein. (319 aa)
	ENSPFOP00000004592	Anaphase promoting complex subunit 2; Belongs to the cullin family. (789 aa)
	bmpr2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1041 aa)
	rnd2	Rho family GTPase 2. (245 aa)
	ist1	IST1 factor associated with ESCRT-III. (348 aa)
	LOC103150927	Fas apoptotic inhibitory molecule b. (181 aa)
	ENSPFOP00000004993	T cell lymphoma invasion and metastasis 2a. (1720 aa)
	ENSPFOP00000005284	Cell cycle associated protein 1a. (674 aa)
	LOC103136233	Layilin b. (367 aa)
	LOC103145329	Fibronectin 1a. (2502 aa)
	ENSPFOP00000005797	Jade family PHD finger 2. (649 aa)
	ENSPFOP00000005809	SH3 domain-containing protein. (283 aa)
	plxna1	Sema domain-containing protein. (1891 aa)
	LOC103148151	NK6 homeobox 2. (281 aa)
	ENSPFOP00000005890	Semaphorin 7A; Belongs to the semaphorin family. (642 aa)
	ENSPFOP00000005910	Immunoglobulin superfamily containing leucine-rich repeat 2. (701 aa)

Your Current Organism:

Poecilia formosa

NCBI taxonomy Id: 48698
Other names: Amazon molly, Limia formosa, Mollienesia formosa, P. formosa

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDKL5	ENSPFOP00000002179	ENSPFOP00000018956	ENSPFOP00000002179	Cyclin dependent kinase like 5.	Methyl CpG binding protein 2.	0.570
ENSPFOP00000000442	ENSPFOP00000005890	ENSPFOP00000000442	ENSPFOP00000005890	Plexin_cytopl domain-containing protein.	Semaphorin 7A; Belongs to the semaphorin family.	0.695
ENSPFOP00000000442	ENSPFOP00000008904	ENSPFOP00000000442	ENSPFOP00000008904	Plexin_cytopl domain-containing protein.	Rho family GTPase 2.	0.518
ENSPFOP00000000442	ENSPFOP00000018431	ENSPFOP00000000442	ENSPFOP00000018431	Plexin_cytopl domain-containing protein.	Si:ch211-113g11.6; Belongs to the semaphorin family.	0.655
ENSPFOP00000000442	ENSPFOP00000028082	ENSPFOP00000000442	ENSPFOP00000028082	Plexin_cytopl domain-containing protein.	Sema domain-containing protein.	0.515
ENSPFOP00000000442	LOC103149862	ENSPFOP00000000442	ENSPFOP00000015443	Plexin_cytopl domain-containing protein.	Uncharacterized protein; Belongs to the semaphorin family.	0.695
ENSPFOP00000000442	LOC103156726	ENSPFOP00000000442	ENSPFOP00000007740	Plexin_cytopl domain-containing protein.	Si:ch211-113g11.6; Belongs to the semaphorin family.	0.655
ENSPFOP00000000442	rnd2	ENSPFOP00000000442	ENSPFOP00000004793	Plexin_cytopl domain-containing protein.	Rho family GTPase 2.	0.518
ENSPFOP00000001341	lig4	ENSPFOP00000001341	ENSPFOP00000000760	RECA_2 domain-containing protein.	DNA ligase.	0.555
ENSPFOP00000001341	xrcc5	ENSPFOP00000001341	ENSPFOP00000000255	RECA_2 domain-containing protein.	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.558
ENSPFOP00000001385	LOC103154418	ENSPFOP00000001385	ENSPFOP00000007585	TIR domain-containing protein.	Interleukin-1.	0.474
ENSPFOP00000001385	SLITRK1	ENSPFOP00000001385	ENSPFOP00000020956	TIR domain-containing protein.	SLIT and NTRK like family member 1.	0.405
ENSPFOP00000001597	kdm1a	ENSPFOP00000001597	ENSPFOP00000010348	Uncharacterized protein.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.483
ENSPFOP00000001843	ENSPFOP00000010303	ENSPFOP00000001843	ENSPFOP00000010303	Protein tyrosine phosphatase receptor type Z1a.	L1 cell adhesion molecule, paralog a.	0.419
ENSPFOP00000001843	LOC103153225	ENSPFOP00000001843	ENSPFOP00000003430	Protein tyrosine phosphatase receptor type Z1a.	Uncharacterized protein.	0.411
ENSPFOP00000001843	LOC103153468	ENSPFOP00000001843	ENSPFOP00000001745	Protein tyrosine phosphatase receptor type Z1a.	Uncharacterized protein.	0.419
ENSPFOP00000001843	il34	ENSPFOP00000001843	ENSPFOP00000015514	Protein tyrosine phosphatase receptor type Z1a.	Interleukin 34.	0.765
ENSPFOP00000002179	CDKL5	ENSPFOP00000002179	ENSPFOP00000018956	Methyl CpG binding protein 2.	Cyclin dependent kinase like 5.	0.570
ENSPFOP00000002179	ENSPFOP00000011279	ENSPFOP00000002179	ENSPFOP00000011279	Methyl CpG binding protein 2.	Forkhead box G1a.	0.675
ENSPFOP00000002179	ENSPFOP00000017823	ENSPFOP00000002179	ENSPFOP00000017823	Methyl CpG binding protein 2.	Fork-head domain-containing protein.	0.675