(79 nodes) Negative regulation of immune response network (Poecilia formosa)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	fgl2	Fibrinogen-like 2a. (503 aa)
	LOC103132374	HD domain-containing protein. (463 aa)
	il10	Interleukin 10. (181 aa)
	LOC103138172	Poly [ADP-ribose] polymerase. (1806 aa)
	LOC103154103	Uncharacterized protein. (370 aa)
	ENSPFOP00000017664	Uncharacterized protein. (638 aa)
	arg2	Arginase. (346 aa)
	LOC103131506	Uncharacterized protein. (963 aa)
	LOC103141874	SAM domain and HD domain 1. (627 aa)
	ENSPFOP00000009372	Fibronectin type-III domain-containing protein. (348 aa)
	tbx21	T-box transcription factor 21. (614 aa)
	ENSPFOP00000010263	Uncharacterized protein. (592 aa)
	psmb4	Proteasome subunit beta; Belongs to the peptidase T1B family. (259 aa)
	ENSPFOP00000010627	Family with sequence similarity 3 member A. (230 aa)
	ENSPFOP00000010720	Uncharacterized protein. (306 aa)
	trafd1	TRAF-type zinc finger domain containing 1. (484 aa)
	acod1	Aconitate decarboxylase 1. (474 aa)
	LYAR	Ly1 antibody reactive. (269 aa)
	OTOP1	Otopetrin 1. (603 aa)
	atg12	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (117 aa)
	ENSPFOP00000011063	Protein tyrosine phosphatase receptor type C. (1210 aa)
	dhx58	DEXH (Asp-Glu-X-His) box polypeptide 58. (681 aa)
	LOC103136325	RAB guanine nucleotide exchange factor (GEF) 1, like. (509 aa)
	LOC103135609	Immunoresponsive gene 1, like. (494 aa)
	ENSPFOP00000012266	Immunoresponsive gene 1, like. (495 aa)
	tnfaip3	Tumor necrosis factor, alpha-induced protein 3. (824 aa)
	cactin	Cactin. (852 aa)
	mettl3	Methyltransferase like 3; Belongs to the MT-A70-like family. (587 aa)
	LOC103151050	Granulin b. (746 aa)
	ENSPFOP00000013513	Regulator of complement activation group 2 gene 2. (284 aa)
	LOC103150091	Peptidoglycan recognition protein 2. (489 aa)
	LOC103134994	Uncharacterized protein. (283 aa)
	LOC103149716	Fibrinogen C-terminal domain-containing protein. (510 aa)
	pias4	Protein inhibitor of activated STAT, 4a. (509 aa)
	LOC103155324	TNFR-Cys domain-containing protein. (260 aa)
	ttll12	Tubulin tyrosine ligase-like family, member 12. (623 aa)
	LOC103132862	Si:dkey-206d17.12. (370 aa)
	parp3	Poly [ADP-ribose] polymerase. (522 aa)
	ENSPFOP00000003773	Si:ch211-157b11.8. (429 aa)
	ythdf2	YTH N(6)-methyladenosine RNA binding protein 2. (638 aa)
	LOC103138600	Si:ch211-203k16.3. (433 aa)
	rc3h1	Ring finger and CCCH-type domains 1b. (1120 aa)
	ENSPFOP00000005856	Arginase. (346 aa)
	ENSPFOP00000029718	Uncharacterized protein. (459 aa)
	nlrx1	NLR family member X1. (956 aa)
	ENSPFOP00000005970	RAB guanine nucleotide exchange factor (GEF) 1. (390 aa)
	cd59	CD59 molecule (CD59 blood group). (117 aa)
	ythdf3	YTH N(6)-methyladenosine RNA binding protein 3. (603 aa)
	samsn1	SAM domain, SH3 domain and nuclear localisation signals 1a. (665 aa)
	IL12B	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (323 aa)
	inpp5d	Inositol polyphosphate-5-phosphatase D. (1083 aa)
	LOC103141893	HD domain-containing protein. (485 aa)
	thoc1	THO complex 1. (654 aa)
	ENSPFOP00000027854	HD domain-containing protein. (457 aa)
	ENSPFOP00000027343	Si:dkey-40g16.6. (257 aa)
	ENSPFOP00000026938	Uncharacterized protein. (206 aa)
	atg5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	ENSPFOP00000024715	Uncharacterized protein. (857 aa)
	ENSPFOP00000023509	Uncharacterized protein. (221 aa)
	ENSPFOP00000023479	DC-STAMP domain containing 1. (518 aa)
	ENSPFOP00000023069	Uncharacterized protein. (510 aa)
	ENSPFOP00000022961	Uncharacterized protein. (208 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (704 aa)
	cd55	Uncharacterized protein. (341 aa)
	ENSPFOP00000022037	annotation not available (162 aa)
	gpr17	G protein-coupled receptor 17. (339 aa)
	rc3h2	Ring finger and CCCH-type domains 2. (1105 aa)
	ENSPFOP00000019114	Si:dkey-175m17.7. (881 aa)
	ENSPFOP00000019064	Aryl hydrocarbon receptor 1b. (867 aa)
	ENSPFOP00000019034	H2.0-like homeo box 1 (Drosophila). (383 aa)
	dusp10	Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (476 aa)
	LOC103147403	Sulfhydryl oxidase. (190 aa)
	mul1	Mitochondrial E3 ubiquitin protein ligase 1b. (352 aa)
	ENSPFOP00000007593	Serpin peptidase inhibitor, clade G (C1 inhibitor), member 1; Belongs to the serpin family. (599 aa)
	ENSPFOP00000007652	Sulfhydryl oxidase. (190 aa)
	ENSPFOP00000008128	Uncharacterized protein. (947 aa)
	zc3h12a	Zinc finger CCCH-type containing 12A. (627 aa)
	LOC103144431	Insulin-like growth factor 2b. (220 aa)
	adar	Adenosine deaminase RNA specific. (1361 aa)

Your Current Organism:

Poecilia formosa

NCBI taxonomy Id: 48698
Other names: Amazon molly, Limia formosa, Mollienesia formosa, P. formosa

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPFOP00000005856	arg2	ENSPFOP00000005856	ENSPFOP00000018010	Arginase.	Arginase.	0.905
ENSPFOP00000005856	il10	ENSPFOP00000005856	ENSPFOP00000016664	Arginase.	Interleukin 10.	0.565
ENSPFOP00000005970	ENSPFOP00000010720	ENSPFOP00000005970	ENSPFOP00000010720	RAB guanine nucleotide exchange factor (GEF) 1.	Uncharacterized protein.	0.464
ENSPFOP00000005970	LOC103136325	ENSPFOP00000005970	ENSPFOP00000012029	RAB guanine nucleotide exchange factor (GEF) 1.	RAB guanine nucleotide exchange factor (GEF) 1, like.	0.664
ENSPFOP00000007593	cd59	ENSPFOP00000007593	ENSPFOP00000006000	Serpin peptidase inhibitor, clade G (C1 inhibitor), member 1; Belongs to the serpin family.	CD59 molecule (CD59 blood group).	0.485
ENSPFOP00000009372	ENSPFOP00000011063	ENSPFOP00000009372	ENSPFOP00000011063	Fibronectin type-III domain-containing protein.	Protein tyrosine phosphatase receptor type C.	0.531
ENSPFOP00000009372	PTPRC	ENSPFOP00000009372	ENSPFOP00000022114	Fibronectin type-III domain-containing protein.	Protein tyrosine phosphatase receptor type C.	0.531
ENSPFOP00000009372	il10	ENSPFOP00000009372	ENSPFOP00000016664	Fibronectin type-III domain-containing protein.	Interleukin 10.	0.858
ENSPFOP00000009372	tbx21	ENSPFOP00000009372	ENSPFOP00000018115	Fibronectin type-III domain-containing protein.	T-box transcription factor 21.	0.435
ENSPFOP00000009372	trafd1	ENSPFOP00000009372	ENSPFOP00000010787	Fibronectin type-III domain-containing protein.	TRAF-type zinc finger domain containing 1.	0.419
ENSPFOP00000010720	ENSPFOP00000005970	ENSPFOP00000010720	ENSPFOP00000005970	Uncharacterized protein.	RAB guanine nucleotide exchange factor (GEF) 1.	0.464
ENSPFOP00000010720	LOC103136325	ENSPFOP00000010720	ENSPFOP00000012029	Uncharacterized protein.	RAB guanine nucleotide exchange factor (GEF) 1, like.	0.464
ENSPFOP00000010720	il10	ENSPFOP00000010720	ENSPFOP00000016664	Uncharacterized protein.	Interleukin 10.	0.808
ENSPFOP00000011063	ENSPFOP00000009372	ENSPFOP00000011063	ENSPFOP00000009372	Protein tyrosine phosphatase receptor type C.	Fibronectin type-III domain-containing protein.	0.531
ENSPFOP00000011063	inpp5d	ENSPFOP00000011063	ENSPFOP00000029091	Protein tyrosine phosphatase receptor type C.	Inositol polyphosphate-5-phosphatase D.	0.405
ENSPFOP00000011063	samsn1	ENSPFOP00000011063	ENSPFOP00000006453	Protein tyrosine phosphatase receptor type C.	SAM domain, SH3 domain and nuclear localisation signals 1a.	0.425
ENSPFOP00000012266	ENSPFOP00000027343	ENSPFOP00000012266	ENSPFOP00000027343	Immunoresponsive gene 1, like.	Si:dkey-40g16.6.	0.525
ENSPFOP00000012266	acod1	ENSPFOP00000012266	ENSPFOP00000010842	Immunoresponsive gene 1, like.	Aconitate decarboxylase 1.	0.905
ENSPFOP00000013513	ENSPFOP00000029718	ENSPFOP00000013513	ENSPFOP00000029718	Regulator of complement activation group 2 gene 2.	Uncharacterized protein.	0.406
ENSPFOP00000013513	cd59	ENSPFOP00000013513	ENSPFOP00000006000	Regulator of complement activation group 2 gene 2.	CD59 molecule (CD59 blood group).	0.518