(37 nodes) Regulation of release of sequestered calcium ion into cytosol network (Poecilia formosa)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

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Your Input:
	ENSPFOP00000025545	Uncharacterized protein. (464 aa)
	ENSPFOP00000020747	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (353 aa)
	LOC103146723	Apelin receptor a; Belongs to the G-protein coupled receptor 1 family. (361 aa)
	ENSPFOP00000020312	Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
	ENSPFOP00000020077	Apelin receptor b; Belongs to the G-protein coupled receptor 1 family. (357 aa)
	calm2-3	Calmodulin. (149 aa)
	ENSPFOP00000017271	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (247 aa)
	ENSPFOP00000016217	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (428 aa)
	casq1	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (482 aa)
	BAX	BCL2 associated X, apoptosis regulator. (191 aa)
	trpc1	Transient receptor potential cation channel, subfamily C, member 1; Belongs to the transient receptor (TC 1.A.4) family. (805 aa)
	ENSPFOP00000014318	Huntingtin. (3086 aa)
	stac3	SH3 and cysteine rich domain 3. (333 aa)
	ENSPFOP00000013650	Selenoprotein N. (558 aa)
	LOC103139789	Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (693 aa)
	calm2-2	Calmodulin. (149 aa)
	ENSPFOP00000010742	A kinase (PRKA) anchor protein 6. (2000 aa)
	calm2	Calmodulin 2a (phosphorylase kinase, delta); Belongs to the calmodulin family. (149 aa)
	LOC103135850	Zgc:171965; Belongs to the G-protein coupled receptor 1 family. (435 aa)
	LOC103147178	Grancalcin. (242 aa)
	ENSPFOP00000006970	Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (764 aa)
	f2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (617 aa)
	ENSPFOP00000005262	Si:dkey-70p6.1. (481 aa)
	ENSPFOP00000004399	Peptidylprolyl isomerase. (146 aa)
	LOC103156860	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (410 aa)
	sri	Uncharacterized protein. (187 aa)
	LOC103156120	Peptidylprolyl isomerase. (108 aa)
	ENSPFOP00000001737	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (393 aa)
	jph2	Junctophilin 2. (806 aa)
	LOC103134208	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (427 aa)
	fkbp1b	Peptidylprolyl isomerase. (108 aa)
	LOC103155215	Si:ch211-146m13.3. (857 aa)
	ENSPFOP00000013324	annotation not available (148 aa)
	LOC103155975	F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family. (392 aa)
	ENSPFOP00000027470	Coagulation factor II (thrombin) receptor; Belongs to the G-protein coupled receptor 1 family. (339 aa)
	LOC103139223	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (290 aa)
	atg5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)

Your Current Organism:

Poecilia formosa

NCBI taxonomy Id: 48698
Other names: Amazon molly, Limia formosa, Mollienesia formosa, P. formosa

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPFOP00000004399	ENSPFOP00000013324	ENSPFOP00000004399	ENSPFOP00000013324	Peptidylprolyl isomerase.	annotation not available	0.779
ENSPFOP00000004399	calm2	ENSPFOP00000004399	ENSPFOP00000009250	Peptidylprolyl isomerase.	Calmodulin 2a (phosphorylase kinase, delta); Belongs to the calmodulin family.	0.779
ENSPFOP00000004399	calm2-2	ENSPFOP00000004399	ENSPFOP00000011793	Peptidylprolyl isomerase.	Calmodulin.	0.779
ENSPFOP00000004399	calm2-3	ENSPFOP00000004399	ENSPFOP00000019989	Peptidylprolyl isomerase.	Calmodulin.	0.779
ENSPFOP00000013324	ENSPFOP00000004399	ENSPFOP00000013324	ENSPFOP00000004399	annotation not available	Peptidylprolyl isomerase.	0.779
ENSPFOP00000013324	LOC103156120	ENSPFOP00000013324	ENSPFOP00000002499	annotation not available	Peptidylprolyl isomerase.	0.779
ENSPFOP00000013324	fkbp1b	ENSPFOP00000013324	ENSPFOP00000001216	annotation not available	Peptidylprolyl isomerase.	0.779
ENSPFOP00000013324	trpc1	ENSPFOP00000013324	ENSPFOP00000014410	annotation not available	Transient receptor potential cation channel, subfamily C, member 1; Belongs to the transient receptor (TC 1.A.4) family.	0.504
ENSPFOP00000014318	atg5	ENSPFOP00000014318	ENSPFOP00000026371	Huntingtin.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.594
ENSPFOP00000016217	LOC103134208	ENSPFOP00000016217	ENSPFOP00000001573	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.738
ENSPFOP00000016217	LOC103156860	ENSPFOP00000016217	ENSPFOP00000003711	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.749
ENSPFOP00000016217	casq1	ENSPFOP00000016217	ENSPFOP00000015064	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.714
ENSPFOP00000020077	LOC103146723	ENSPFOP00000020077	ENSPFOP00000020468	Apelin receptor b; Belongs to the G-protein coupled receptor 1 family.	Apelin receptor a; Belongs to the G-protein coupled receptor 1 family.	0.922
ENSPFOP00000027470	LOC103135850	ENSPFOP00000027470	ENSPFOP00000008997	Coagulation factor II (thrombin) receptor; Belongs to the G-protein coupled receptor 1 family.	Zgc:171965; Belongs to the G-protein coupled receptor 1 family.	0.640
ENSPFOP00000027470	f2	ENSPFOP00000027470	ENSPFOP00000005858	Coagulation factor II (thrombin) receptor; Belongs to the G-protein coupled receptor 1 family.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.989
LOC103134208	ENSPFOP00000016217	ENSPFOP00000001573	ENSPFOP00000016217	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.738
LOC103134208	LOC103139789	ENSPFOP00000001573	ENSPFOP00000013276	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.	0.416
LOC103134208	LOC103156860	ENSPFOP00000001573	ENSPFOP00000003711	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.904
LOC103134208	casq1	ENSPFOP00000001573	ENSPFOP00000015064	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.639
LOC103134208	jph2	ENSPFOP00000001573	ENSPFOP00000001623	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Junctophilin 2.	0.424