(97 nodes) Cell chemotaxis network (Poecilia formosa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103129871	SEFIR domain-containing protein. (817 aa)
	LOC103145765	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (687 aa)
	LOC103133028	Galectin. (330 aa)
	tnfsf11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (268 aa)
	ENSPFOP00000002532	SEFIR domain-containing protein. (499 aa)
	LOC103148710	Chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1); Belongs to the intercrine alpha (chemokine CxC) family. (102 aa)
	LOC103154153	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (259 aa)
	ENSPFOP00000002700	Chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1); Belongs to the intercrine alpha (chemokine CxC) family. (84 aa)
	ENSPFOP00000002818	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (421 aa)
	LOC103142365	Endothelin 2. (163 aa)
	ENSPFOP00000003322	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (688 aa)
	LOC103144528	Heparin-binding EGF-like growth factor a. (236 aa)
	ENSPFOP00000003624	Heparin-binding EGF-like growth factor a. (238 aa)
	cxcl14	Chemokine (C-X-C motif) ligand 14. (99 aa)
	ENSPFOP00000004442	Chemokine (C-C motif) ligand 25b. (119 aa)
	ENSPFOP00000004443	SCY domain-containing protein. (96 aa)
	prkcq	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (715 aa)
	LOC103142445	SCY domain-containing protein. (97 aa)
	LOC103145943	C-X-C motif chemokine. (104 aa)
	LOC103139278	G_PROTEIN_RECEP_F1_2 domain-containing protein. (317 aa)
	ENSPFOP00000005457	Endothelin receptor type Bb; Belongs to the G-protein coupled receptor 1 family. (415 aa)
	ENSPFOP00000005834	Chemokine (C motif) receptor 1b, duplicate 1; Belongs to the G-protein coupled receptor 1 family. (324 aa)
	ENSPFOP00000005958	Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. (454 aa)
	ENSPFOP00000006024	Chemokine (C-C motif) receptor 6b; Belongs to the G-protein coupled receptor 1 family. (341 aa)
	ppib	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (216 aa)
	LOC103134026	Chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1). (98 aa)
	ENSPFOP00000007236	Secretogranin II (chromogranin C), b. (567 aa)
	CKLF	Chemokine like factor. (149 aa)
	gab1	GRB2-associated binding protein 1. (756 aa)
	nrp1	Neuropilin; Belongs to the neuropilin family. (919 aa)
	srp54	Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (504 aa)
	LOC103151217	C-C motif chemokine. (107 aa)
	CCN3	Cellular communication network factor 3. (367 aa)
	ENSPFOP00000009709	SCY domain-containing protein. (112 aa)
	gas6	Uncharacterized protein. (650 aa)
	ENSPFOP00000010528	SCY domain-containing protein. (92 aa)
	LOC103140636	C-C motif chemokine. (91 aa)
	ENSPFOP00000011033	Lymphoid enhancer-binding factor 1. (370 aa)
	LOC103131102	Cytochrome P450, family 7, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (496 aa)
	tafa4	TAFA chemokine like family member 4b. (135 aa)
	LOC103147771	Galectin. (277 aa)
	arhgef16	Rho guanine nucleotide exchange factor (GEF) 16. (714 aa)
	LOC103145206	CRK proto-oncogene, adaptor protein. (306 aa)
	LOC103134747	Si:ch211-184m13.4; Belongs to the G-protein coupled receptor 1 family. (342 aa)
	lpar1	Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (351 aa)
	chga	Chromogranin A. (343 aa)
	LOC103135627	Uncharacterized protein. (214 aa)
	ENSPFOP00000014087	Uncharacterized protein. (604 aa)
	dock4	Dedicator of cytokinesis 4b; Belongs to the DOCK family. (1890 aa)
	LOC103140783	Uncharacterized protein. (200 aa)
	LOC103129769	MFS domain-containing protein. (450 aa)
	LOC103145077	SEFIR domain-containing protein. (684 aa)
	ENSPFOP00000014818	Ninjurin 1. (119 aa)
	LOC103151569	Endothelin receptor Ba; Belongs to the G-protein coupled receptor 1 family. (425 aa)
	ENSPFOP00000015962	Uncharacterized protein. (295 aa)
	trim33	Tripartite motif containing 33. (1223 aa)
	ano6	Anoctamin. (918 aa)
	slc37a4	Solute carrier family 37 member 4a. (429 aa)
	LOC103138174	Chemokine (C-X-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family. (386 aa)
	LOC103140233	Pleiotrophin. (161 aa)
	LOC103144739	Galectin. (373 aa)
	ENSPFOP00000018448	Galectin. (263 aa)
	LOC103138101	Ninjurin 1. (150 aa)
	CXCL8	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (96 aa)
	CXCL8-2	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (111 aa)
	ENSPFOP00000029913	SCY domain-containing protein. (102 aa)
	crkl	V-crk avian sarcoma virus CT10 oncogene homolog-like. (299 aa)
	ENSPFOP00000019778	Uncharacterized protein. (263 aa)
	LOC103134746	G protein-coupled receptor 183a; Belongs to the G-protein coupled receptor 1 family. (386 aa)
	LOC103129464	Atypical chemokine receptor 3. (363 aa)
	ENSPFOP00000020182	Ras homolog gene family, member Gd. (200 aa)
	LOC103134214	Atypical chemokine receptor 3a; Belongs to the G-protein coupled receptor 1 family. (379 aa)
	ENSPFOP00000020285	Chemokine (C-X-C motif) receptor 1; Belongs to the G-protein coupled receptor 1 family. (396 aa)
	LOC103139220	Chemokine (C-X-C motif) receptor 3, tandem duplicate 2; Belongs to the G-protein coupled receptor 1 family. (376 aa)
	LOC103151916	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (351 aa)
	ENSPFOP00000020569	Chemokine (C-C motif) receptor 10; Belongs to the G-protein coupled receptor 1 family. (385 aa)
	cxcr5	Chemokine (C-X-C motif) receptor 5; Belongs to the G-protein coupled receptor 1 family. (364 aa)
	LOC103142579	Chemokine (C motif) receptor 1a, duplicate 1; Belongs to the G-protein coupled receptor 1 family. (336 aa)
	ENSPFOP00000020984	Chemokine (C-C motif) receptor 8.1; Belongs to the G-protein coupled receptor 1 family. (362 aa)
	agtr1	Angiotensin II receptor, type 1b; Belongs to the G-protein coupled receptor 1 family. (363 aa)
	LOC103140437	Atypical chemokine receptor 4b; Belongs to the G-protein coupled receptor 1 family. (371 aa)
	ENSPFOP00000021064	Si:dkey-211g8.6. (297 aa)
	ENSPFOP00000021073	Atypical chemokine receptor 4a; Belongs to the G-protein coupled receptor 1 family. (394 aa)
	ENSPFOP00000022274	C-C motif chemokine. (111 aa)
	LOC103132237	Uncharacterized protein. (617 aa)
	ENSPFOP00000024972	C-X-C motif chemokine. (105 aa)
	vegfa	Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family. (214 aa)
	ENSPFOP00000028532	SCY domain-containing protein. (89 aa)
	ENSPFOP00000028547	Phosphoinositide kinase, FYVE finger containing. (1597 aa)
	ENSPFOP00000029851	Uncharacterized protein. (362 aa)
	LOC103151809	SEFIR domain-containing protein. (761 aa)
	gbf1	Golgi brefeldin A resistant guanine nucleotide exchange factor 1. (1865 aa)
	ENSPFOP00000000811	G_PROTEIN_RECEP_F1_2 domain-containing protein. (331 aa)
	CCR6	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (342 aa)
	ENSPFOP00000000889	PH domain-containing protein. (749 aa)
	ENSPFOP00000001058	Basigin. (273 aa)
	LOC103129750	Ras homolog family member Gb. (191 aa)

Your Current Organism:

Poecilia formosa

NCBI taxonomy Id: 48698
Other names: Amazon molly, Limia formosa, Mollienesia formosa, P. formosa

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCR6	CXCL8	ENSPFOP00000000821	ENSPFOP00000019753	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family.	0.546
CCR6	CXCL8-2	ENSPFOP00000000821	ENSPFOP00000019754	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family.	0.461
CCR6	ENSPFOP00000002700	ENSPFOP00000000821	ENSPFOP00000002700	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	Chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1); Belongs to the intercrine alpha (chemokine CxC) family.	0.660
CCR6	ENSPFOP00000004442	ENSPFOP00000000821	ENSPFOP00000004442	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	Chemokine (C-C motif) ligand 25b.	0.673
CCR6	ENSPFOP00000004443	ENSPFOP00000000821	ENSPFOP00000004443	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	SCY domain-containing protein.	0.637
CCR6	ENSPFOP00000006024	ENSPFOP00000000821	ENSPFOP00000006024	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	Chemokine (C-C motif) receptor 6b; Belongs to the G-protein coupled receptor 1 family.	0.888
CCR6	ENSPFOP00000009709	ENSPFOP00000000821	ENSPFOP00000009709	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	SCY domain-containing protein.	0.745
CCR6	ENSPFOP00000010528	ENSPFOP00000000821	ENSPFOP00000010528	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	SCY domain-containing protein.	0.676
CCR6	ENSPFOP00000020984	ENSPFOP00000000821	ENSPFOP00000020984	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	Chemokine (C-C motif) receptor 8.1; Belongs to the G-protein coupled receptor 1 family.	0.410
CCR6	ENSPFOP00000022274	ENSPFOP00000000821	ENSPFOP00000022274	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine.	0.712
CCR6	ENSPFOP00000024972	ENSPFOP00000000821	ENSPFOP00000024972	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	C-X-C motif chemokine.	0.615
CCR6	ENSPFOP00000028532	ENSPFOP00000000821	ENSPFOP00000028532	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	SCY domain-containing protein.	0.637
CCR6	ENSPFOP00000029913	ENSPFOP00000000821	ENSPFOP00000029913	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	SCY domain-containing protein.	0.615
CCR6	LOC103134026	ENSPFOP00000000821	ENSPFOP00000006577	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	Chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1).	0.660
CCR6	LOC103140636	ENSPFOP00000000821	ENSPFOP00000010540	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine.	0.553
CCR6	LOC103142445	ENSPFOP00000000821	ENSPFOP00000004598	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	SCY domain-containing protein.	0.650
CCR6	LOC103148710	ENSPFOP00000000821	ENSPFOP00000002663	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	Chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1); Belongs to the intercrine alpha (chemokine CxC) family.	0.660
CCR6	LOC103151217	ENSPFOP00000000821	ENSPFOP00000009491	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine.	0.891
CCR6	cxcl14	ENSPFOP00000000821	ENSPFOP00000004419	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	Chemokine (C-X-C motif) ligand 14.	0.662
CCR6	cxcr5	ENSPFOP00000000821	ENSPFOP00000020600	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	Chemokine (C-X-C motif) receptor 5; Belongs to the G-protein coupled receptor 1 family.	0.423