(19 nodes) Positive regulation of signaling receptor activity network (Poecilia formosa)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	tgfa	Transforming growth factor, alpha. (248 aa)
	cacng4	Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (333 aa)
	ereg	EGF-like domain-containing protein. (154 aa)
	ENSPFOP00000021041	G_PROTEIN_RECEP_F1_2 domain-containing protein. (385 aa)
	GREM1	Gremlin. (182 aa)
	rwdd1	RWD domain containing 1. (240 aa)
	il10	Interleukin 10. (181 aa)
	adam17	ADAM metallopeptidase domain 17b. (841 aa)
	RELN	Reelin. (3467 aa)
	LOC103142045	EGF-like domain-containing protein. (178 aa)
	cacng3	Calcium voltage-gated channel auxiliary subunit gamma 3. (317 aa)
	cacng2	Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (317 aa)
	edn1	Endothelin 1. (187 aa)
	LOC103144243	ADAM metallopeptidase domain 17a. (859 aa)
	ENSPFOP00000005463	Neutrophil cytosolic factor 1. (439 aa)
	pink1	PTEN induced kinase 1. (575 aa)
	LOC103144528	Heparin-binding EGF-like growth factor a. (236 aa)
	ENSPFOP00000003624	Heparin-binding EGF-like growth factor a. (238 aa)
	ENSPFOP00000003756	Uncharacterized protein. (176 aa)

Your Current Organism:

Poecilia formosa

NCBI taxonomy Id: 48698
Other names: Amazon molly, Limia formosa, Mollienesia formosa, P. formosa

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPFOP00000003624	ENSPFOP00000003756	ENSPFOP00000003624	ENSPFOP00000003756	Heparin-binding EGF-like growth factor a.	Uncharacterized protein.	0.751
ENSPFOP00000003624	LOC103142045	ENSPFOP00000003624	ENSPFOP00000011943	Heparin-binding EGF-like growth factor a.	EGF-like domain-containing protein.	0.721
ENSPFOP00000003624	LOC103144243	ENSPFOP00000003624	ENSPFOP00000005449	Heparin-binding EGF-like growth factor a.	ADAM metallopeptidase domain 17a.	0.604
ENSPFOP00000003624	adam17	ENSPFOP00000003624	ENSPFOP00000015966	Heparin-binding EGF-like growth factor a.	ADAM metallopeptidase domain 17b.	0.604
ENSPFOP00000003624	ereg	ENSPFOP00000003624	ENSPFOP00000022331	Heparin-binding EGF-like growth factor a.	EGF-like domain-containing protein.	0.741
ENSPFOP00000003624	tgfa	ENSPFOP00000003624	ENSPFOP00000030071	Heparin-binding EGF-like growth factor a.	Transforming growth factor, alpha.	0.718
ENSPFOP00000003756	ENSPFOP00000003624	ENSPFOP00000003756	ENSPFOP00000003624	Uncharacterized protein.	Heparin-binding EGF-like growth factor a.	0.751
ENSPFOP00000003756	LOC103142045	ENSPFOP00000003756	ENSPFOP00000011943	Uncharacterized protein.	EGF-like domain-containing protein.	0.837
ENSPFOP00000003756	LOC103144528	ENSPFOP00000003756	ENSPFOP00000003590	Uncharacterized protein.	Heparin-binding EGF-like growth factor a.	0.751
ENSPFOP00000003756	ereg	ENSPFOP00000003756	ENSPFOP00000022331	Uncharacterized protein.	EGF-like domain-containing protein.	0.823
ENSPFOP00000003756	tgfa	ENSPFOP00000003756	ENSPFOP00000030071	Uncharacterized protein.	Transforming growth factor, alpha.	0.675
ENSPFOP00000021041	edn1	ENSPFOP00000021041	ENSPFOP00000005291	G_PROTEIN_RECEP_F1_2 domain-containing protein.	Endothelin 1.	0.645
LOC103142045	ENSPFOP00000003624	ENSPFOP00000011943	ENSPFOP00000003624	EGF-like domain-containing protein.	Heparin-binding EGF-like growth factor a.	0.721
LOC103142045	ENSPFOP00000003756	ENSPFOP00000011943	ENSPFOP00000003756	EGF-like domain-containing protein.	Uncharacterized protein.	0.837
LOC103142045	LOC103144528	ENSPFOP00000011943	ENSPFOP00000003590	EGF-like domain-containing protein.	Heparin-binding EGF-like growth factor a.	0.721
LOC103142045	ereg	ENSPFOP00000011943	ENSPFOP00000022331	EGF-like domain-containing protein.	EGF-like domain-containing protein.	0.803
LOC103142045	tgfa	ENSPFOP00000011943	ENSPFOP00000030071	EGF-like domain-containing protein.	Transforming growth factor, alpha.	0.800
LOC103144243	ENSPFOP00000003624	ENSPFOP00000005449	ENSPFOP00000003624	ADAM metallopeptidase domain 17a.	Heparin-binding EGF-like growth factor a.	0.604
LOC103144243	LOC103144528	ENSPFOP00000005449	ENSPFOP00000003590	ADAM metallopeptidase domain 17a.	Heparin-binding EGF-like growth factor a.	0.604
LOC103144243	adam17	ENSPFOP00000005449	ENSPFOP00000015966	ADAM metallopeptidase domain 17a.	ADAM metallopeptidase domain 17b.	0.923