(17 nodes) Kringle network (Poecilia formosa)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	ENSPFOP00000031030	Uncharacterized protein. (744 aa)
	plat	Plasminogen activator, tissue. (608 aa)
	MUSK	Muscle associated receptor tyrosine kinase. (934 aa)
	LOC103150898	Uncharacterized protein. (473 aa)
	ENSPFOP00000002523	Hepatocyte growth factor a; Belongs to the peptidase S1 family. Plasminogen subfamily. (674 aa)
	f2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (617 aa)
	ENSPFOP00000002923	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (792 aa)
	hgfac	HGF activator. (588 aa)
	ENSPFOP00000006025	Serine protease 12; Belongs to the peptidase S1 family. (794 aa)
	ENSPFOP00000007936	Plasminogen activator, urokinase a; Belongs to the peptidase S1 family. (373 aa)
	ror1	Receptor tyrosine kinase-like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (953 aa)
	ENSPFOP00000009449	Phosphoinositide-3-kinase interacting protein 1. (264 aa)
	ENSPFOP00000011595	Si:ch73-127m5.1; Belongs to the peptidase S1 family. (817 aa)
	ENSPFOP00000014457	Kringle containing transmembrane protein 1. (476 aa)
	mst1l	Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (709 aa)
	ENSPFOP00000018395	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (726 aa)
	ENSPFOP00000019318	Uncharacterized protein. (612 aa)

Your Current Organism:

Poecilia formosa

NCBI taxonomy Id: 48698
Other names: Amazon molly, Limia formosa, Mollienesia formosa, P. formosa

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPFOP00000002523	ENSPFOP00000002923	ENSPFOP00000002523	ENSPFOP00000002923	Hepatocyte growth factor a; Belongs to the peptidase S1 family. Plasminogen subfamily.	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	0.479
ENSPFOP00000002523	ENSPFOP00000019318	ENSPFOP00000002523	ENSPFOP00000019318	Hepatocyte growth factor a; Belongs to the peptidase S1 family. Plasminogen subfamily.	Uncharacterized protein.	0.420
ENSPFOP00000002523	hgfac	ENSPFOP00000002523	ENSPFOP00000006008	Hepatocyte growth factor a; Belongs to the peptidase S1 family. Plasminogen subfamily.	HGF activator.	0.709
ENSPFOP00000002923	ENSPFOP00000002523	ENSPFOP00000002923	ENSPFOP00000002523	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	Hepatocyte growth factor a; Belongs to the peptidase S1 family. Plasminogen subfamily.	0.479
ENSPFOP00000002923	ENSPFOP00000007936	ENSPFOP00000002923	ENSPFOP00000007936	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	Plasminogen activator, urokinase a; Belongs to the peptidase S1 family.	0.752
ENSPFOP00000002923	ENSPFOP00000018395	ENSPFOP00000002923	ENSPFOP00000018395	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.476
ENSPFOP00000002923	ENSPFOP00000019318	ENSPFOP00000002923	ENSPFOP00000019318	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	Uncharacterized protein.	0.624
ENSPFOP00000002923	LOC103150898	ENSPFOP00000002923	ENSPFOP00000012783	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	Uncharacterized protein.	0.758
ENSPFOP00000002923	f2	ENSPFOP00000002923	ENSPFOP00000005858	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.931
ENSPFOP00000002923	hgfac	ENSPFOP00000002923	ENSPFOP00000006008	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	HGF activator.	0.888
ENSPFOP00000002923	mst1l	ENSPFOP00000002923	ENSPFOP00000016102	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily.	0.500
ENSPFOP00000002923	plat	ENSPFOP00000002923	ENSPFOP00000013137	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	Plasminogen activator, tissue.	0.751
ENSPFOP00000006025	MUSK	ENSPFOP00000006025	ENSPFOP00000012505	Serine protease 12; Belongs to the peptidase S1 family.	Muscle associated receptor tyrosine kinase.	0.462
ENSPFOP00000006025	hgfac	ENSPFOP00000006025	ENSPFOP00000006008	Serine protease 12; Belongs to the peptidase S1 family.	HGF activator.	0.566
ENSPFOP00000007936	ENSPFOP00000002923	ENSPFOP00000007936	ENSPFOP00000002923	Plasminogen activator, urokinase a; Belongs to the peptidase S1 family.	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	0.752
ENSPFOP00000007936	hgfac	ENSPFOP00000007936	ENSPFOP00000006008	Plasminogen activator, urokinase a; Belongs to the peptidase S1 family.	HGF activator.	0.599
ENSPFOP00000011595	MUSK	ENSPFOP00000011595	ENSPFOP00000012505	Si:ch73-127m5.1; Belongs to the peptidase S1 family.	Muscle associated receptor tyrosine kinase.	0.462
ENSPFOP00000011595	hgfac	ENSPFOP00000011595	ENSPFOP00000006008	Si:ch73-127m5.1; Belongs to the peptidase S1 family.	HGF activator.	0.566
ENSPFOP00000018395	ENSPFOP00000002923	ENSPFOP00000018395	ENSPFOP00000002923	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	0.476
ENSPFOP00000018395	ENSPFOP00000019318	ENSPFOP00000018395	ENSPFOP00000019318	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	Uncharacterized protein.	0.442