(16 nodes) DHS-like NAD/FAD-binding domain superfamily network (Poecilia formosa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ilvbl	IlvB (bacterial acetolactate synthase)-like; Belongs to the TPP enzyme family. (628 aa)
	LOC103142995	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. (306 aa)
	etfa	Electron transfer flavoprotein subunit alpha. (333 aa)
	sirt7	Sirtuin 7. (409 aa)
	sirt2	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (383 aa)
	ENSPFOP00000005242	Nicotinamide nucleotide transhydrogenase 2. (1072 aa)
	ENSPFOP00000005564	2-hydroxyacyl-CoA lyase 1; Belongs to the TPP enzyme family. (871 aa)
	LOC103150389	2-hydroxyacyl-CoA lyase 1; Belongs to the TPP enzyme family. (588 aa)
	sirt1	Sirtuin 1. (677 aa)
	dhps	Deoxyhypusine synthase. (365 aa)
	sirt6	Sirtuin 6. (390 aa)
	ENSPFOP00000016616	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (372 aa)
	sirt4	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily. (310 aa)
	LOC103148176	Nicotinamide nucleotide transhydrogenase. (1087 aa)
	SIRT5	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. (306 aa)
	ENSPFOP00000028564	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (292 aa)

Your Current Organism:

Poecilia formosa

NCBI taxonomy Id: 48698
Other names: Amazon molly, Limia formosa, Mollienesia formosa, P. formosa

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPFOP00000005242	ENSPFOP00000016616	ENSPFOP00000005242	ENSPFOP00000016616	Nicotinamide nucleotide transhydrogenase 2.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.894
ENSPFOP00000005242	ENSPFOP00000028564	ENSPFOP00000005242	ENSPFOP00000028564	Nicotinamide nucleotide transhydrogenase 2.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.895
ENSPFOP00000005242	LOC103142995	ENSPFOP00000005242	ENSPFOP00000000223	Nicotinamide nucleotide transhydrogenase 2.	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	0.895
ENSPFOP00000005242	LOC103148176	ENSPFOP00000005242	ENSPFOP00000019841	Nicotinamide nucleotide transhydrogenase 2.	Nicotinamide nucleotide transhydrogenase.	0.894
ENSPFOP00000005242	SIRT5	ENSPFOP00000005242	ENSPFOP00000026058	Nicotinamide nucleotide transhydrogenase 2.	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	0.894
ENSPFOP00000005242	sirt1	ENSPFOP00000005242	ENSPFOP00000010381	Nicotinamide nucleotide transhydrogenase 2.	Sirtuin 1.	0.895
ENSPFOP00000005242	sirt2	ENSPFOP00000005242	ENSPFOP00000003166	Nicotinamide nucleotide transhydrogenase 2.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.895
ENSPFOP00000005242	sirt4	ENSPFOP00000005242	ENSPFOP00000018246	Nicotinamide nucleotide transhydrogenase 2.	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily.	0.895
ENSPFOP00000005242	sirt6	ENSPFOP00000005242	ENSPFOP00000012793	Nicotinamide nucleotide transhydrogenase 2.	Sirtuin 6.	0.895
ENSPFOP00000005242	sirt7	ENSPFOP00000005242	ENSPFOP00000003160	Nicotinamide nucleotide transhydrogenase 2.	Sirtuin 7.	0.895
ENSPFOP00000016616	ENSPFOP00000005242	ENSPFOP00000016616	ENSPFOP00000005242	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	Nicotinamide nucleotide transhydrogenase 2.	0.894
ENSPFOP00000016616	LOC103142995	ENSPFOP00000016616	ENSPFOP00000000223	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	0.819
ENSPFOP00000016616	LOC103148176	ENSPFOP00000016616	ENSPFOP00000019841	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	Nicotinamide nucleotide transhydrogenase.	0.923
ENSPFOP00000016616	SIRT5	ENSPFOP00000016616	ENSPFOP00000026058	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	0.818
ENSPFOP00000016616	sirt1	ENSPFOP00000016616	ENSPFOP00000010381	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	Sirtuin 1.	0.834
ENSPFOP00000016616	sirt2	ENSPFOP00000016616	ENSPFOP00000003166	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.729
ENSPFOP00000016616	sirt4	ENSPFOP00000016616	ENSPFOP00000018246	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily.	0.865
ENSPFOP00000016616	sirt6	ENSPFOP00000016616	ENSPFOP00000012793	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	Sirtuin 6.	0.790
ENSPFOP00000016616	sirt7	ENSPFOP00000016616	ENSPFOP00000003160	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	Sirtuin 7.	0.761
ENSPFOP00000028564	ENSPFOP00000005242	ENSPFOP00000028564	ENSPFOP00000005242	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	Nicotinamide nucleotide transhydrogenase 2.	0.895