(16 nodes) Rhomboid-like superfamily network (Poecilia formosa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSPFOP00000000738	Rhomboid domain-containing protein. (626 aa)
	tmem115	Transmembrane protein 115. (387 aa)
	ENSPFOP00000001971	Rhomboid-related protein 2; Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors; Belongs to the peptidase S54 family. (295 aa)
	ENSPFOP00000004700	Presenilin associated, rhomboid-like a. (390 aa)
	rhbdd3	Rhomboid domain containing 3. (363 aa)
	LOC103150886	Rhomboid domain-containing protein. (357 aa)
	LOC103143771	Rhomboid 5 homolog 1a (Drosophila). (898 aa)
	ENSPFOP00000011933	Rhomboid, veinlet-like 3 (Drosophila). (318 aa)
	RHBDF2	Rhomboid 5 homolog 2. (826 aa)
	LOC103134911	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (231 aa)
	rhbdd1	Rhomboid domain containing 1. (317 aa)
	ENSPFOP00000018249	UBA domain containing 2. (354 aa)
	ENSPFOP00000018854	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (254 aa)
	ENSPFOP00000019155	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (255 aa)
	ENSPFOP00000020270	Rhomboid domain-containing protein. (232 aa)
	rhbdl1	Rhomboid-related protein 1; May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors; Belongs to the peptidase S54 family. (372 aa)

Your Current Organism:

Poecilia formosa

NCBI taxonomy Id: 48698
Other names: Amazon molly, Limia formosa, Mollienesia formosa, P. formosa

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPFOP00000001971	ENSPFOP00000004700	ENSPFOP00000001971	ENSPFOP00000004700	Rhomboid-related protein 2; Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors; Belongs to the peptidase S54 family.	Presenilin associated, rhomboid-like a.	0.407
ENSPFOP00000001971	LOC103150886	ENSPFOP00000001971	ENSPFOP00000009219	Rhomboid-related protein 2; Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors; Belongs to the peptidase S54 family.	Rhomboid domain-containing protein.	0.407
ENSPFOP00000001971	rhbdd3	ENSPFOP00000001971	ENSPFOP00000007642	Rhomboid-related protein 2; Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors; Belongs to the peptidase S54 family.	Rhomboid domain containing 3.	0.412
ENSPFOP00000004700	ENSPFOP00000001971	ENSPFOP00000004700	ENSPFOP00000001971	Presenilin associated, rhomboid-like a.	Rhomboid-related protein 2; Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors; Belongs to the peptidase S54 family.	0.407
ENSPFOP00000011933	ENSPFOP00000018249	ENSPFOP00000011933	ENSPFOP00000018249	Rhomboid, veinlet-like 3 (Drosophila).	UBA domain containing 2.	0.444
ENSPFOP00000018249	ENSPFOP00000011933	ENSPFOP00000018249	ENSPFOP00000011933	UBA domain containing 2.	Rhomboid, veinlet-like 3 (Drosophila).	0.444
ENSPFOP00000018249	ENSPFOP00000019155	ENSPFOP00000018249	ENSPFOP00000019155	UBA domain containing 2.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.567
ENSPFOP00000018249	ENSPFOP00000020270	ENSPFOP00000018249	ENSPFOP00000020270	UBA domain containing 2.	Rhomboid domain-containing protein.	0.482
ENSPFOP00000018249	rhbdd3	ENSPFOP00000018249	ENSPFOP00000007642	UBA domain containing 2.	Rhomboid domain containing 3.	0.402
ENSPFOP00000018249	tmem115	ENSPFOP00000018249	ENSPFOP00000000164	UBA domain containing 2.	Transmembrane protein 115.	0.407
ENSPFOP00000018854	ENSPFOP00000019155	ENSPFOP00000018854	ENSPFOP00000019155	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.993
ENSPFOP00000018854	LOC103134911	ENSPFOP00000018854	ENSPFOP00000014031	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.928
ENSPFOP00000019155	ENSPFOP00000018249	ENSPFOP00000019155	ENSPFOP00000018249	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	UBA domain containing 2.	0.567
ENSPFOP00000019155	ENSPFOP00000018854	ENSPFOP00000019155	ENSPFOP00000018854	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.993
ENSPFOP00000019155	LOC103134911	ENSPFOP00000019155	ENSPFOP00000014031	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.990
ENSPFOP00000020270	ENSPFOP00000018249	ENSPFOP00000020270	ENSPFOP00000018249	Rhomboid domain-containing protein.	UBA domain containing 2.	0.482
ENSPFOP00000020270	rhbdd3	ENSPFOP00000020270	ENSPFOP00000007642	Rhomboid domain-containing protein.	Rhomboid domain containing 3.	0.558
LOC103134911	ENSPFOP00000018854	ENSPFOP00000014031	ENSPFOP00000018854	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.928
LOC103134911	ENSPFOP00000019155	ENSPFOP00000014031	ENSPFOP00000019155	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.990
LOC103150886	ENSPFOP00000001971	ENSPFOP00000009219	ENSPFOP00000001971	Rhomboid domain-containing protein.	Rhomboid-related protein 2; Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors; Belongs to the peptidase S54 family.	0.407