(52 nodes) Synthesis of bile acids and bile salts network (Poecilia formosa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ncoa1	Nuclear receptor coactivator 1. (1444 aa)
	ENSPFOP00000005015	Hydroxysteroid (17-beta) dehydrogenase 4. (741 aa)
	ENSPFOP00000031170	acyl-CoA thioesterase 8. (177 aa)
	LOC103137478	Oxysterol-binding protein; Belongs to the OSBP family. (761 aa)
	ENSPFOP00000005832	Uncharacterized protein. (632 aa)
	ENSPFOP00000006444	Oxysterol binding protein-like 2a. (436 aa)
	osbpl9	Oxysterol-binding protein; Belongs to the OSBP family. (739 aa)
	LOC103136384	Oxysterol-binding protein; Belongs to the OSBP family. (763 aa)
	LOC103151840	Oxysterol-binding protein; Belongs to the OSBP family. (763 aa)
	ENSPFOP00000009522	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (543 aa)
	ENSPFOP00000010717	Nuclear receptor coactivator. (1433 aa)
	LOC103131102	Cytochrome P450, family 7, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (496 aa)
	sugct	Succinyl-CoA:glutarate-CoA transferase. (415 aa)
	rxra	Retinoid X receptor, alpha a. (496 aa)
	ENSPFOP00000012144	Nuclear receptor coactivator 2. (1328 aa)
	ENSPFOP00000013667	Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase; Belongs to the 3-beta-HSD family. (365 aa)
	ENSPFOP00000013742	Cytochrome P450, family 7, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. (476 aa)
	LOC103138135	Uncharacterized protein; Belongs to the cytochrome P450 family. (509 aa)
	LOC103138011	Uncharacterized protein. (441 aa)
	ENSPFOP00000024388	Uncharacterized protein. (371 aa)
	LOC103154010	Oxysterol-binding protein; Belongs to the OSBP family. (471 aa)
	ch25h	Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. (249 aa)
	ENSPFOP00000001219	Hydroxysteroid dehydrogenase like 2. (416 aa)
	LOC103144076	Acyl-CoA thioesterase 8. (337 aa)
	ENSPFOP00000016614	Oxysterol-binding protein; Belongs to the OSBP family. (737 aa)
	ENSPFOP00000016867	Acyl-CoA thioesterase 16. (420 aa)
	LOC103152705	Acyl-CoA thioesterase 19. (437 aa)
	LOC103147236	Oxysterol-binding protein; Belongs to the OSBP family. (874 aa)
	ENSPFOP00000017309	Prostaglandin I2 (prostacyclin) synthase; Belongs to the cytochrome P450 family. (487 aa)
	LOC103143583	Uncharacterized protein. (621 aa)
	LOC103143584	Solute carrier family 27 member 2a. (619 aa)
	osbpl7	Oxysterol-binding protein; Belongs to the OSBP family. (862 aa)
	LOC103154130	Si:ch211-113j14.1; Belongs to the cytochrome P450 family. (536 aa)
	ENSPFOP00000019868	Oxysterol-binding protein; Belongs to the OSBP family. (763 aa)
	ENSPFOP00000020024	Cholesterol 25-hydroxylase like 1, tandem duplicate 2; Belongs to the sterol desaturase family. (282 aa)
	ENSPFOP00000020375	Cholesterol 25-hydroxylase like 2; Belongs to the sterol desaturase family. (271 aa)
	LOC103144302	Uncharacterized protein. (467 aa)
	ENSPFOP00000023750	BAAT_C domain-containing protein. (204 aa)
	LOC103145254	Oxysterol-binding protein; Belongs to the OSBP family. (820 aa)
	PTGIS	Prostaglandin I2 synthase; Belongs to the cytochrome P450 family. (483 aa)
	OSBPL1A	Oxysterol-binding protein; Belongs to the OSBP family. (969 aa)
	ENSPFOP00000003012	Uncharacterized protein. (508 aa)
	osbpl3	Oxysterol-binding protein; Belongs to the OSBP family. (884 aa)
	LOC103147688	Uncharacterized protein. (507 aa)
	ENSPFOP00000015024	Oxysterol-binding protein; Belongs to the OSBP family. (921 aa)
	HSD3B7	Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7; Belongs to the 3-beta-HSD family. (369 aa)
	podn	Podocan. (587 aa)
	LOC103150482	Nuclear receptor subfamily 1, group H, member 5. (492 aa)
	LOC103134814	Si:dkey-91i10.3; Belongs to the cytochrome P450 family. (534 aa)
	nr1h4	Nuclear receptor subfamily 1, group H, member 4. (485 aa)
	ENSPFOP00000003559	Cholesterol 25-hydroxylase like 1, tandem duplicate 1; Belongs to the sterol desaturase family. (273 aa)
	amacr	Alpha-methylacyl-CoA racemase. (382 aa)

Your Current Organism:

Poecilia formosa

NCBI taxonomy Id: 48698
Other names: Amazon molly, Limia formosa, Mollienesia formosa, P. formosa

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPFOP00000001219	ENSPFOP00000003012	ENSPFOP00000001219	ENSPFOP00000003012	Hydroxysteroid dehydrogenase like 2.	Uncharacterized protein.	0.509
ENSPFOP00000001219	ENSPFOP00000005015	ENSPFOP00000001219	ENSPFOP00000005015	Hydroxysteroid dehydrogenase like 2.	Hydroxysteroid (17-beta) dehydrogenase 4.	0.641
ENSPFOP00000001219	ENSPFOP00000005832	ENSPFOP00000001219	ENSPFOP00000005832	Hydroxysteroid dehydrogenase like 2.	Uncharacterized protein.	0.648
ENSPFOP00000001219	ENSPFOP00000009522	ENSPFOP00000001219	ENSPFOP00000009522	Hydroxysteroid dehydrogenase like 2.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.910
ENSPFOP00000001219	ENSPFOP00000013667	ENSPFOP00000001219	ENSPFOP00000013667	Hydroxysteroid dehydrogenase like 2.	Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase; Belongs to the 3-beta-HSD family.	0.592
ENSPFOP00000001219	ENSPFOP00000013742	ENSPFOP00000001219	ENSPFOP00000013742	Hydroxysteroid dehydrogenase like 2.	Cytochrome P450, family 7, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family.	0.507
ENSPFOP00000001219	ENSPFOP00000016867	ENSPFOP00000001219	ENSPFOP00000016867	Hydroxysteroid dehydrogenase like 2.	Acyl-CoA thioesterase 16.	0.524
ENSPFOP00000001219	ENSPFOP00000017309	ENSPFOP00000001219	ENSPFOP00000017309	Hydroxysteroid dehydrogenase like 2.	Prostaglandin I2 (prostacyclin) synthase; Belongs to the cytochrome P450 family.	0.478
ENSPFOP00000001219	ENSPFOP00000023750	ENSPFOP00000001219	ENSPFOP00000023750	Hydroxysteroid dehydrogenase like 2.	BAAT_C domain-containing protein.	0.648
ENSPFOP00000001219	ENSPFOP00000024388	ENSPFOP00000001219	ENSPFOP00000024388	Hydroxysteroid dehydrogenase like 2.	Uncharacterized protein.	0.494
ENSPFOP00000001219	ENSPFOP00000031170	ENSPFOP00000001219	ENSPFOP00000031170	Hydroxysteroid dehydrogenase like 2.	acyl-CoA thioesterase 8.	0.716
ENSPFOP00000001219	HSD3B7	ENSPFOP00000001219	ENSPFOP00000015430	Hydroxysteroid dehydrogenase like 2.	Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7; Belongs to the 3-beta-HSD family.	0.592
ENSPFOP00000001219	LOC103131102	ENSPFOP00000001219	ENSPFOP00000011125	Hydroxysteroid dehydrogenase like 2.	Cytochrome P450, family 7, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family.	0.533
ENSPFOP00000001219	LOC103134814	ENSPFOP00000001219	ENSPFOP00000016240	Hydroxysteroid dehydrogenase like 2.	Si:dkey-91i10.3; Belongs to the cytochrome P450 family.	0.494
ENSPFOP00000001219	LOC103138011	ENSPFOP00000001219	ENSPFOP00000014089	Hydroxysteroid dehydrogenase like 2.	Uncharacterized protein.	0.648
ENSPFOP00000001219	LOC103138135	ENSPFOP00000001219	ENSPFOP00000013942	Hydroxysteroid dehydrogenase like 2.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.494
ENSPFOP00000001219	LOC103143583	ENSPFOP00000001219	ENSPFOP00000017712	Hydroxysteroid dehydrogenase like 2.	Uncharacterized protein.	0.648
ENSPFOP00000001219	LOC103143584	ENSPFOP00000001219	ENSPFOP00000017746	Hydroxysteroid dehydrogenase like 2.	Solute carrier family 27 member 2a.	0.648
ENSPFOP00000001219	LOC103144076	ENSPFOP00000001219	ENSPFOP00000001503	Hydroxysteroid dehydrogenase like 2.	Acyl-CoA thioesterase 8.	0.716
ENSPFOP00000001219	LOC103144302	ENSPFOP00000001219	ENSPFOP00000022568	Hydroxysteroid dehydrogenase like 2.	Uncharacterized protein.	0.524